Entry Database : PDB / ID : 2awu Structure visualization Downloads & linksTitle Synapse associated protein 97 PDZ2 domain variant C378G ComponentsAHH Synapse-associated protein 97 DetailsKeywords MEMBRANE PROTEIN / synaptic signaling / trafficking proteinFunction / homology Function and homology informationFunction Domain/homology Component
tissue morphogenesis / regulation of protein localization to synapse / regulation of potassium ion import / L27 domain binding / regulation of potassium ion export across plasma membrane / MPP7-DLG1-LIN7 complex / membrane raft organization / hard palate development / establishment of centrosome localization / negative regulation of p38MAPK cascade ... tissue morphogenesis / regulation of protein localization to synapse / regulation of potassium ion import / L27 domain binding / regulation of potassium ion export across plasma membrane / MPP7-DLG1-LIN7 complex / membrane raft organization / hard palate development / establishment of centrosome localization / negative regulation of p38MAPK cascade / cortical microtubule organization / embryonic skeletal system morphogenesis / astral microtubule organization / structural constituent of postsynaptic density / lateral loop / reproductive structure development / immunological synapse formation / myelin sheath abaxonal region / peristalsis / cell projection membrane / smooth muscle tissue development / paranode region of axon / bicellular tight junction assembly / positive regulation of potassium ion transport / Trafficking of AMPA receptors / Activation of Ca-permeable Kainate Receptor / node of Ranvier / regulation of ventricular cardiac muscle cell action potential / protein-containing complex localization / establishment or maintenance of epithelial cell apical/basal polarity / amyloid precursor protein metabolic process / Synaptic adhesion-like molecules / RAF/MAP kinase cascade / neurotransmitter receptor localization to postsynaptic specialization membrane / endothelial cell proliferation / lens development in camera-type eye / regulation of myelination / ureteric bud development / cortical actin cytoskeleton organization / branching involved in ureteric bud morphogenesis / negative regulation of G1/S transition of mitotic cell cycle / positive regulation of actin filament polymerization / receptor clustering / kinesin binding / microvillus / immunological synapse / basement membrane / lateral plasma membrane / potassium channel regulator activity / bicellular tight junction / Unblocking of NMDA receptors, glutamate binding and activation / phosphatase binding / postsynaptic density, intracellular component / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / T cell proliferation / negative regulation of T cell proliferation / cellular response to brain-derived neurotrophic factor stimulus / T-tubule / T cell activation / actin filament polymerization / phosphatidylinositol 3-kinase/protein kinase B signal transduction / basal plasma membrane / synaptic membrane / protein localization to plasma membrane / PDZ domain binding / regulation of membrane potential / actin filament organization / positive regulation of protein localization to plasma membrane / postsynaptic density membrane / ionotropic glutamate receptor binding / neuromuscular junction / protein localization / negative regulation of ERK1 and ERK2 cascade / cytoplasmic side of plasma membrane / cerebral cortex development / synaptic vesicle membrane / cell-cell adhesion / negative regulation of epithelial cell proliferation / regulation of protein localization / cell-cell junction / cell junction / presynaptic membrane / regulation of cell shape / chemical synaptic transmission / basolateral plasma membrane / postsynaptic membrane / microtubule / transmembrane transporter binding / cell population proliferation / molecular adaptor activity / postsynaptic density / cell adhesion / neuron projection / membrane raft / apical plasma membrane / neuronal cell body / glutamatergic synapse / synapse / dendrite / positive regulation of cell population proliferation Similarity search - Function L27-1 / L27_1 / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / L27 domain superfamily / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors ... L27-1 / L27_1 / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / L27 domain superfamily / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / PDZ domain / Pdz3 Domain / PDZ domain / SH3 domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Roll / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.44 Å DetailsAuthors Von Ossowski, I. / Oksanen, E. / Von Ossowski, L. / Cai, C. / Sundberg, M. / Goldman, A. / Keinanen, K. CitationJournal : Febs J. / Year : 2006Title : Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptideAuthors : von Ossowski, I. / Oksanen, E. / von Ossowski, L. / Cai, C. / Sundberg, M. / Goldman, A. / Keinanen, K. History Deposition Sep 2, 2005 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Aug 29, 2006 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Oct 11, 2017 Group : Refinement description / Category : software / Item : _software.classification / _software.nameRevision 1.4 Nov 10, 2021 Group : Data collection / Database references / Category : database_2 / diffrn_source / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _diffrn_source.pdbx_synchrotron_site / _struct_ref_seq_dif.details Revision 1.5 May 29, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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