4RBW
Crystal structure of human alpha-defensin 5, HD5 (Thr7Arg Glu21Arg mutant)
Summary for 4RBW
Entry DOI | 10.2210/pdb4rbw/pdb |
Related | 1ZMP 4E82 4E83 4E86 4RBX |
Descriptor | Defensin-5, SULFATE ION, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | mutant t7r e21r-hd5, beta-sheet, antimicrobial peptide, paneth cells defensin, human alpha-defensin, antimicrobial protein |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : Q01523 |
Total number of polymer chains | 4 |
Total formula weight | 15649.07 |
Authors | Pazgier, M.,Gohain, N.,Tolbert, W.D. (deposition date: 2014-09-13, release date: 2015-07-29, Last modification date: 2023-09-20) |
Primary citation | Wang, C.,Shen, M.,Gohain, N.,Tolbert, W.D.,Chen, F.,Zhang, N.,Yang, K.,Wang, A.,Su, Y.,Cheng, T.,Zhao, J.,Pazgier, M.,Wang, J. Design of a potent antibiotic peptide based on the active region of human defensin 5. J.Med.Chem., 58:3083-3093, 2015 Cited by PubMed: 25782105DOI: 10.1021/jm501824a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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