登録情報 データベース : PDB / ID : 4b70 構造の表示 ダウンロードとリンクタイトル Aminoimidazoles as BACE-1 Inhibitors: From De Novo Design to Ab- lowering in Brain 要素BETA-SECRETASE 1 詳細 キーワード HYDROLASE / HYDROLASE INHIBITOR / LEAD GENERATION / STRUCTURE-BASED DRUG DESIGN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / hippocampal mossy fiber to CA3 synapse / multivesicular body / response to lead ion / trans-Golgi network / protein processing / recycling endosome / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / synaptic vesicle / late endosome / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / lysosome / early endosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.6 Å 詳細データ登録者 Gravenfors, Y. / Blid, J. / Ginman, T. / Karlstrom, S. / Kihlstrom, J. / Kolmodin, K. / Lindstrom, J. / Berg, S. / Kieseritzky, F. / Slivo, C. ...Gravenfors, Y. / Blid, J. / Ginman, T. / Karlstrom, S. / Kihlstrom, J. / Kolmodin, K. / Lindstrom, J. / Berg, S. / Kieseritzky, F. / Slivo, C. / Swahn, B. / Viklund, J. / Olsson, L. / Johansson, P. / Eketjall, S. / Falting, J. / Jeppsson, F. / Stromberg, K. / Janson, J. / Rahm, F. 引用ジャーナル : J.Med.Chem. / 年 : 2013タイトル : Core Refinement Toward Permeable Beta-Secretase (Bace-1) Inhibitors with Low Herg Activity.著者: Ginman, T. / Viklund, J. / Malmstrom, J. / Blid, J. / Emond, R. / Forsblom, R. / Johansson, A. / Kers, A. / Lake, F. / Sehgelmeble, F. / Sterky, K.J. / Bergh, M. / Lindgren, A. / Johansson, P. ... 著者 : Ginman, T. / Viklund, J. / Malmstrom, J. / Blid, J. / Emond, R. / Forsblom, R. / Johansson, A. / Kers, A. / Lake, F. / Sehgelmeble, F. / Sterky, K.J. / Bergh, M. / Lindgren, A. / Johansson, P. / Jeppsson, F. / Falting, J. / Gravenfors, Y. / Rahm, F. 履歴 登録 2012年8月16日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2013年6月26日 Provider : repository / タイプ : Initial release改定 1.1 2013年7月3日 Group : Database references
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