MOTOR PROTEIN/SIGNALING PROTEIN / MOTOR PROTEIN-SIGNALING PROTEIN COMPLEX / ENDOCYTOSIS / PROTEIN TRANSPORT / CALMODULIN-BINDING / TRANSPORT / ACTIN-BINDING / GOLGI APPARATUS
Function / homology
Function and homology information
negative regulation of phospholipase C-activating phototransduction signaling pathway / myosin VI complex / myosin VI head/neck binding / myosin VII complex / negative regulation of opsin-mediated signaling pathway / photoreceptor cell axon guidance / rhabdomere development / rhabdomere / detection of chemical stimulus involved in sensory perception of smell / myosin V complex ...negative regulation of phospholipase C-activating phototransduction signaling pathway / myosin VI complex / myosin VI head/neck binding / myosin VII complex / negative regulation of opsin-mediated signaling pathway / photoreceptor cell axon guidance / rhabdomere development / rhabdomere / detection of chemical stimulus involved in sensory perception of smell / myosin V complex / regulation of secretion / kinetochore organization / autophagic cell death / G protein-coupled opsin signaling pathway / actin filament-based movement / inner ear auditory receptor cell differentiation / myosin V binding / cellular response to ethanol / myosin complex / clathrin-coated vesicle / inner ear morphogenesis / microfilament motor activity / muscle cell cellular homeostasis / mitotic spindle pole / myosin heavy chain binding / channel regulator activity / filamentous actin / cytoskeletal motor activity / centriole replication / microvillus / DNA damage response, signal transduction by p53 class mediator / enzyme regulator activity / ruffle / centriole / filopodium / actin filament organization / actin filament / sensory perception of sound / intracellular protein transport / mitotic spindle / ADP binding / ruffle membrane / spindle / endocytosis / actin filament binding / protein localization / sensory perception of smell / actin cytoskeleton / cell cortex / midbody / cytoplasmic vesicle / nuclear membrane / calmodulin binding / centrosome / calcium ion binding / perinuclear region of cytoplasm / Golgi apparatus / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function
Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #2980 / Alpha-Beta Plaits - #1590 / Arc Repressor Mutant, subunit A - #820 / Myosin VI head, motor domain, U50 subdomain / : / Myosin VI, lever arm / Myosin VI, cargo binding domain / Class VI myosin, motor domain / Myosin VI cargo binding domain / Myosin S1 fragment, N-terminal ...Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #2980 / Alpha-Beta Plaits - #1590 / Arc Repressor Mutant, subunit A - #820 / Myosin VI head, motor domain, U50 subdomain / : / Myosin VI, lever arm / Myosin VI, cargo binding domain / Class VI myosin, motor domain / Myosin VI cargo binding domain / Myosin S1 fragment, N-terminal / Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #530 / Kinesin motor domain / Kinesin / Myosin S1 fragment, N-terminal / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Myosin head, motor domain / Myosin head (motor domain) / Myosin motor domain profile. / Myosin. Large ATPases. / : / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Kinesin motor domain superfamily / Four Helix Bundle (Hemerythrin (Met), subunit A) / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / EF-hand domain pair / Helix non-globular / EF-hand, calcium binding motif / Special / SH3 type barrels. / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Arc Repressor Mutant, subunit A / Roll / Alpha-Beta Plaits / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / 2-Layer Sandwich / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Beta / Mainly Alpha / Alpha Beta Similarity search - Domain/homology
Mass: 18.015 Da / Num. of mol.: 251 / Source method: isolated from a natural source / Formula: H2O
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Details
Compound details
ENGINEERED RESIDUE IN CHAIN A, ALA 303 TO GLY ENGINEERED RESIDUE IN CHAIN A, GLY 548 TO VAL ...ENGINEERED RESIDUE IN CHAIN A, ALA 303 TO GLY ENGINEERED RESIDUE IN CHAIN A, GLY 548 TO VAL ENGINEERED RESIDUE IN CHAIN A, ALA 573 TO ARG ENGINEERED RESIDUE IN CHAIN A, TYR 574 TO ASP ENGINEERED RESIDUE IN CHAIN A, VAL 715 TO LEU ENGINEERED RESIDUE IN CHAIN A, SER 722 TO TYR ENGINEERED RESIDUE IN CHAIN A, LEU 723 TO MET
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 1.84 Å3/Da / Density % sol: 33.37 % / Description: NONE
Crystal grow
pH: 6.75 Details: 10.8% PEG 8000, 50 MM MES PH 6.75, 175 MM AMMONIUM SULFATE, 3% ISO-PROPANOL, 3% TERT-BUTANOL, 4 MM EGTA. SOLUTION OF PROTEIN AT 18 MG/ML.
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