Entry Database : PDB / ID : 2vas Structure visualization Downloads & linksTitle Myosin VI (MD-insert2-CaM, Delta-Insert1) Post-rigor state ComponentsCALMODULIN MYOSIN VI DetailsKeywords MOTOR PROTEIN / CALMODULIN-BINDING / NUCLEOTIDE-BINDING / TRANSPORT / CALMODULIN / ENDOCYTOSIS / MG.ADP.BEFX / CAM / MYOSIN / NUCLEUS / MEMBRANE / MYOSIN VI / CYTOPLASM / GOLGI APPARATUS / PHOSPHORYLATION / MOLECULAR MOTOR / ATP-BINDING / COILED COIL / ACTIN-BINDING / POST-RIGOR STATE / PROTEIN TRANSPORTFunction / homology Function and homology informationFunction Domain/homology Component
metarhodopsin inactivation / regulation of light-activated channel activity / myosin VI head/neck binding / CaMK IV-mediated phosphorylation of CREB / Calmodulin induced events / Cam-PDE 1 activation / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / PKA activation / myosin VI complex / eNOS activation ... metarhodopsin inactivation / regulation of light-activated channel activity / myosin VI head/neck binding / CaMK IV-mediated phosphorylation of CREB / Calmodulin induced events / Cam-PDE 1 activation / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / PKA activation / myosin VI complex / eNOS activation / Inactivation, recovery and regulation of the phototransduction cascade / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / VEGFR2 mediated vascular permeability / CLEC7A (Dectin-1) induces NFAT activation / Glycogen breakdown (glycogenolysis) / Extra-nuclear estrogen signaling / Activation of RAC1 downstream of NMDARs / Calcineurin activates NFAT / adaptation of rhodopsin mediated signaling / myosin VII complex / Synthesis of IP3 and IP4 in the cytosol / Ion transport by P-type ATPases / Ca2+ pathway / RAF activation / Platelet degranulation / photoreceptor cell axon guidance / FCERI mediated Ca+2 mobilization / Ion homeostasis / deactivation of rhodopsin mediated signaling / RAS processing / Protein methylation / Activation of Ca-permeable Kainate Receptor / rhabdomere development / Unblocking of NMDA receptors, glutamate binding and activation / regulation of secretion / myosin V complex / salivary gland cell autophagic cell death / kinetochore organization / rhabdomere / RNA polymerase II, holoenzyme / Neutrophil degranulation / actin filament-based movement / rhodopsin mediated signaling pathway / inner ear auditory receptor cell differentiation / myosin V binding / cellular response to ethanol / positive regulation of cation channel activity / vesicle transport along actin filament / inner ear morphogenesis / myosin complex / microfilament motor activity / clathrin-coated vesicle / muscle cell cellular homeostasis / myosin heavy chain binding / mitotic spindle pole / filamentous actin / DNA damage response, signal transduction by p53 class mediator / microvillus / centriole replication / cytoskeletal motor activity / centriole / enzyme regulator activity / ruffle / actin filament organization / filopodium / actin filament / calcium-mediated signaling / ADP binding / sensory perception of sound / intracellular protein transport / spindle / ruffle membrane / mitotic spindle / cell cortex / sensory perception of smell / endocytosis / actin cytoskeleton / actin filament binding / midbody / nuclear membrane / cytoplasmic vesicle / calmodulin binding / vesicle / centrosome / protein phosphorylation / calcium ion binding / perinuclear region of cytoplasm / Golgi apparatus / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / plasma membrane / nucleus / cytosol / cytoplasm Similarity search - Function Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #2980 / Alpha-Beta Plaits - #1590 / Arc Repressor Mutant, subunit A - #820 / Myosin VI head, motor domain, U50 subdomain / Myosin VI, cargo binding domain / Class VI myosin, motor domain / Myosin VI cargo binding domain / Myosin S1 fragment, N-terminal / Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #530 / Calmodulin ... Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #2980 / Alpha-Beta Plaits - #1590 / Arc Repressor Mutant, subunit A - #820 / Myosin VI head, motor domain, U50 subdomain / Myosin VI, cargo binding domain / Class VI myosin, motor domain / Myosin VI cargo binding domain / Myosin S1 fragment, N-terminal / Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #530 / Calmodulin / Kinesin motor domain / Kinesin / Myosin S1 fragment, N-terminal / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Myosin head (motor domain) / Myosin motor domain profile. / Myosin head, motor domain / Myosin. Large ATPases. / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Kinesin motor domain superfamily / EF-hand domain pair / Four Helix Bundle (Hemerythrin (Met), subunit A) / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / EF-hand, calcium binding motif / Helix non-globular / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / Special / SH3 type barrels. / EF-hand domain pair / Arc Repressor Mutant, subunit A / Roll / Alpha-Beta Plaits / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / 2-Layer Sandwich / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Beta / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species SUS SCROFA (pig)DROSOPHILA MELANOGASTER (fruit fly)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.4 Å DetailsAuthors Menetrey, J. / Llinas, P. / Cicolari, J. / Squires, G. / Liu, X. / Li, A. / Sweeney, H.L. / Houdusse, A. CitationJournal : Embo J. / Year : 2008Title : The Post-Rigor Structure of Myosin Vi and Implications for the Recovery Stroke.Authors : Menetrey, J. / Llinas, P. / Cicolari, J. / Squires, G. / Liu, X. / Li, A. / Sweeney, H.L. / Houdusse, A. History Deposition Sep 4, 2007 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 11, 2007 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format compliance
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