タイプ 環状ペプチド / 免疫抑制剤 詳細 CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE. HERE, CYCLOSPORIN A IS REPRESENTED BY THE SEQUENCE (SEQRES) CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE. CYCLIZATION IS ACHIEVED BY LINKING THE N- AND THE C- TERMINI. ダウンロード Molecular definition / Chemical definition / Family definition別称 (E)-14,17,26,32-tetrabutyl-5-ethyl-8-(1-hydroxy-2-methylhex-4-enyl)-1,3,9,12,15,18,20,23,27-nonamethyl-11,29-dipropyl-1,3,6,9,12,15,18,21,24,27,30- undecaazacyclodotriacontan-2,4,7,10,13,16,19,22,25,28,31-undecaone (ChemSpider) Abrammune (SciFinder) Antibiotic S 7481F1 (SciFinder, ChemSpider) Apo-Cyclosporine (ChemBank) Arpimune ME (SciFinder) Atopica (Merck, ChemBank) CYCLOSPORIN (PDB) Cicloral (SciFinder) Cicloral (antibiotic) (SciFinder) Ciclosporin (SciFinder, KEGG, DrugBank, PubChem, ChemBank) Ciclosporina Germed (SciFinder) Cipol N (SciFinder, ChemSpider, ChemBank) Consupren (SciFinder, PubChem, ChemSpider, ChemBank) Consupren S (ChemSpider) Cyclokat (PubChem) Cyclosporin (DrugBank, PubChem) Cyclosporin A (KEGG, DrugBank, ChemBank) Cyclosporine (SciFinder, KEGG, ChemSpider, ChemBank) Cyclosporine A (SciFinder, PubChem, ChemBank) Debio088 (SciFinder) Equoral (SciFinder, ChemSpider) Gengraf (SciFinder, KEGG, DrugBank, ChemSpider, ChemBank) Imusporin (SciFinder) Modusik-A (ChemSpider) NSC 290193 (SciFinder) Neoplanta (SciFinder, ChemSpider, ChemBank) Neoral (SciFinder, Merck, KEGG, DrugBank, ChemSpider, ChemBank) OL 27-400 (SciFinder) Optimmune (Merck, ChemSpider, ChemBank) Papilock (ChemSpider) Papilock Mini (SciFinder) Pulminiq (ChemSpider, ChemBank) Ramihyphin A (SciFinder, PubChem, ChemSpider, ChemBank) Restasis (SciFinder, Merck, KEGG, DrugBank, ChemBank) Rhoxal-cyclosporine (ChemBank) S 7481F1 (ChemSpider) S-Neoral (SciFinder, ChemSpider) SDZ-OXL 400 (SciFinder) Sandimmun (SciFinder, ChemBank) Sandimmun Neoral (SciFinder, ChemBank) Sandimmune (SciFinder, Merck, KEGG, DrugBank, PubChem, ChemSpider, ChemBank) Sandimmune I.V. (ChemBank) Sandimmune Neoral (SciFinder) Sandoz-cyclosporine (ChemBank) Sang 35 (ChemBank) Sang-35 (SciFinder) SangCyA (SciFinder) SangCya (ChemBank) Sangcya (DrugBank) Sigmasporin (PubChem) Sigmasporin Microoral (SciFinder) Zinograf ME (SciFinder) ciclosporin (Merck, Norine) ciclosporine (Norine) cyclosporin A (PubChem) cyclosporine (Merck, Norine, PubChem) 残り52件を表示 表示を減らすAnnotation 分子機能 : 免疫抑制剤 / 情報源 : KEGG分子機能 : 免疫抑制剤 / 情報源 : DrugBank分子機能 : binds to cyclophilin and forms a complex to inhibit calcineurin, which is normally responsible for activating transcription of interleukin 2 / 情報源 : DrugBank分子機能 : inhibitor of T-lymphocytes in the G0 or G1 phase of cell cycle / 情報源 : DrugBank分子機能 : inhibitor of lymphokine production and Interleukin release / 情報源 : DrugBank分子機能 : used in organ and tissue transplants for prophylactic treatment / 情報源 : DrugBank分子機能 : Immunomodulating, antibiotic / 情報源 : Norine分子機能 : used to prevent rejections in organ and bone marrow transplants / 情報源 : Norine作用機序 : Binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase - it inhibits mitochondrial permeability transition pore opening however, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient. / 情報源 : www.enzolifesciences.comApplication : Important diagnostic tool for the characterization of permeability transition-related phenomena. / 情報源 : www.enzolifesciences.com作用機序 : Weak immunosuppressor. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. BML-PE160) in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. / 情報源 : www.enzolifesciences.com分子機能 : immunosuppressive agent / 情報源 : ChemBank分子機能 : anti-fungal / 情報源 : ChemBank分子機能 : immunosuppressive drug, binds cyclosporin A (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A), EC: 5.2.1.8 EC: immunosuppressive drug, binds cyclosporin A (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A), EC: 5.2.1.8 / 情報源 : PubMed: 8075981由来 External info 残り16件を表示 表示を減らすFamily Cyclosporin Cyclosporin A / Cyclosporin D / Cyclosporin C ... Cyclosporin A / Cyclosporin D / Cyclosporin C / CYCLOSPORIN D, 5,7 mutation / CYCLOSPORIN A, 5 mutation / CYCLOSPORIN A, 6 mutation / CYCLOSPORIN A, 7 mutation / CYCLOSPORIN A, 8 mutation / Cyclosporin A variant, MLE 8 to MNL / Cyclosporin D variant, MSA 7 to MAA / Cyclosporin C variant (DAL 1 to VAD, MLE 3 to LEU, VAL 9 to LEU) / Mutant CYCLOSPORIN D
Related structures Iodo-cyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: ICYSPA / Reference Cyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: DEKSAN / Reference Cyclosporin A monohydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: KEPNAU / Reference (-4-PSI-5-,CS-NH,-7-PSI-8-,CS-NH)-Cyclosporin A diethyl ether solvate, seqres C11 ALA*-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: JOKMAX / Reference methyl((4S)-METHYL)NORLEU-4 Cyclosporin cyclophilin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-THR*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: LIKNIC / Reference cyclo-(alanyl-d-alanyl-n-methylleucyl-n-methylleucyl-N-methylvalyl-alpha-(1-oxo-2-methylhex-4-enyl)sarcosyl-valyl-sarcosyl-N-methylleucyl-valyl-N-methylleucyl), seqres C11 ALA-ALA-LEU*-LEU*-VAL*-SAR*-VAL*-SAR-LEU*-VAL-LEU*- / CCDC: ZADRIF / Reference sulfhydryl cyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: ZAJDUJ / Reference isocyclosporin A acetone solvate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*,GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: NAMPIA / Reference cyclosporin A dimethylisosorbide solvate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: TECRIC / Reference cyclosporin E acetone solveate monohydrate clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-THR*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: SUQNUN / Reference O-acetyl-(4R)-4-(E-2-butenyl)-4,N-dimethyl-L-threonylcyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: CUQRUB / Reference O-acetyl-(4R)-4-(4-bromobutyl)-4,N-dimethyl-L-threonylcyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: CUQSAI / Reference cyclosporin H diethyl ether solvate monohydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-THR*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: DUDQAU / Reference cyclosporin V t-butyl methyl ether clathrate, seqres C11 GLY*-ALA-LEU*-LEU*-VAL*-THR*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: HUCVIK / Reference dihydrocyclosporin A t-butyl methyl ether clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: HUCVOQ / Reference cyclosporin A tetrahydrofuran clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: LOWGOT / Reference cyclosporin A di-n-butyl ether clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: LOWHAG / Reference cyclosporin A di-n-butyl ether clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: LOWHAG01 / Reference cyclosporin G methanol solvate hydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-NVA-SAR-LEU*-VAL-LEU*- / CCDC: GABWOW / Reference cyclosporin G methanol solvate hydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-NVA-SAR-LEU*-VAL-LEU*- / CCDC: GABWUC / Reference cyclosporin H hexahydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: GABXAJ / Reference cyclosporin H hydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: GABXEN / Reference cyclosporin A acetone monohydrate clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-SAR*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: KADFOL / Reference cyclo-(alanyl-D-alanyl-N-methylleucyl-N-methylleucyl-N-methylvalyl-alpha-(1-oxo-2-methylhex-4-enyl)sarcosyl-valyl-sarcosyl-N-methylleucyl-valyl-N-methylleucyl) di-isopropyl ether solvate hemihydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-SAR*-VAL*-SAR-LEU*-VAL-LEU*- / CCDC: ZADREB / Reference Cyclosporin A monohydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: KEPNAU01 Cyclosporin A hydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*- / CCDC: LOSLEL 残り22件を表示 表示を減らす