登録情報 データベース : PDB / ID : 2w17 構造の表示 ダウンロードとリンクタイトル CDK2 in complex with the imidazole pyrimidine amide, compound (S)-8b 要素CELL DIVISION PROTEIN KINASE 2 詳細 キーワード TRANSFERASE / KINASE / MITOSIS / CELL CYCLE / SERINE/THREONINE-PROTEIN KINASE / ATP-BINDING / CELL DIVISION / PHOSPHOPROTEIN / PHOSPHORYLATION / NUCLEOTIDE-BINDING機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cyclin A1-CDK2 complex / cyclin E2-CDK2 complex / cyclin E1-CDK2 complex / cyclin A2-CDK2 complex / positive regulation of DNA-templated DNA replication initiation / G2 Phase / cyclin-dependent protein kinase activity / Y chromosome / Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes / positive regulation of heterochromatin formation ... cyclin A1-CDK2 complex / cyclin E2-CDK2 complex / cyclin E1-CDK2 complex / cyclin A2-CDK2 complex / positive regulation of DNA-templated DNA replication initiation / G2 Phase / cyclin-dependent protein kinase activity / Y chromosome / Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes / positive regulation of heterochromatin formation / p53-Dependent G1 DNA Damage Response / X chromosome / PTK6 Regulates Cell Cycle / regulation of anaphase-promoting complex-dependent catabolic process / Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) / centriole replication / Regulation of APC/C activators between G1/S and early anaphase / centrosome duplication / Telomere Extension By Telomerase / G0 and Early G1 / Activation of the pre-replicative complex / cellular response to nitric oxide / cyclin-dependent protein kinase holoenzyme complex / cyclin-dependent kinase / cyclin-dependent protein serine/threonine kinase activity / TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest / Activation of ATR in response to replication stress / Cyclin E associated events during G1/S transition / Cyclin A/B1/B2 associated events during G2/M transition / Cajal body / Cyclin A:Cdk2-associated events at S phase entry / condensed chromosome / mitotic G1 DNA damage checkpoint signaling / regulation of mitotic cell cycle / regulation of G2/M transition of mitotic cell cycle / cyclin binding / post-translational protein modification / : / meiotic cell cycle / positive regulation of DNA replication / male germ cell nucleus / potassium ion transport / DNA Damage/Telomere Stress Induced Senescence / CDK-mediated phosphorylation and removal of Cdc6 / Meiotic recombination / SCF(Skp2)-mediated degradation of p27/p21 / Orc1 removal from chromatin / G1/S transition of mitotic cell cycle / Transcriptional regulation of granulopoiesis / G2/M transition of mitotic cell cycle / Cyclin D associated events in G1 / cellular senescence / Regulation of TP53 Degradation / nuclear envelope / Factors involved in megakaryocyte development and platelet production / Processing of DNA double-strand break ends / Senescence-Associated Secretory Phenotype (SASP) / regulation of gene expression / peptidyl-serine phosphorylation / DNA replication / Regulation of TP53 Activity through Phosphorylation / transcription regulator complex / Ras protein signal transduction / chromosome, telomeric region / endosome / chromatin remodeling / protein domain specific binding / cell division / protein phosphorylation / DNA repair / protein serine kinase activity / protein serine/threonine kinase activity / DNA-templated transcription / centrosome / positive regulation of cell population proliferation / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / magnesium ion binding / signal transduction / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. ... Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 ACETATE ION / Chem-I19 / Cyclin-dependent kinase 2 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.15 Å 詳細データ登録者 Jones, C.D. / Andrews, D.M. / Barker, A.J. / Blades, K. / Daunt, P. / East, S. / Geh, C. / Graham, M.A. / Johnson, K.M. / Loddick, S.A. ...Jones, C.D. / Andrews, D.M. / Barker, A.J. / Blades, K. / Daunt, P. / East, S. / Geh, C. / Graham, M.A. / Johnson, K.M. / Loddick, S.A. / McFarland, H.M. / McGregor, A. / Moss, L. / Rudge, D.A. / Simpson, P.B. / Swain, M.L. / Tam, K.Y. / Tucker, J.A. / Walker, M. / Brassington, C. / Haye, H. / McCall, E. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2008タイトル : The Discovery of Azd5597, a Potent Imidazole Pyrimidine Amide Cdk Inhibitor Suitable for Intravenous Dosing.著者: Jones, C.D. / Andrews, D.M. / Barker, A.J. / Blades, K. / Daunt, P. / East, S. / Geh, C. / Graham, M.A. / Johnson, K.M. / Loddick, S.A. / Mcfarland, H.M. / Mcgregor, A. / Moss, L. / Rudge, D. ... 著者 : Jones, C.D. / Andrews, D.M. / Barker, A.J. / Blades, K. / Daunt, P. / East, S. / Geh, C. / Graham, M.A. / Johnson, K.M. / Loddick, S.A. / Mcfarland, H.M. / Mcgregor, A. / Moss, L. / Rudge, D.A. / Simpson, P.B. / Swain, M.L. / Tam, K.Y. / Tucker, J.A. / Walker, M. 履歴 登録 2008年10月15日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2008年11月4日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Advisory / Version format compliance改定 1.2 2019年4月24日 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Other / Source and taxonomy カテゴリ : entity_src_gen / pdbx_database_proc ... entity_src_gen / pdbx_database_proc / pdbx_database_status / struct_conn Item : _entity_src_gen.pdbx_host_org_cell_line / _pdbx_database_status.recvd_author_approval / _struct_conn.pdbx_leaving_atom_flag改定 1.3 2024年5月1日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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