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1WUG
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COMPLEX STRUCTURE OF PCAF BROMODOMAIN WITH SMALL CHEMICAL LIGAND NP1
Descriptor:Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE
Authors:Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., Zhou, M.M.
Deposit date:2004-12-07
Release date:2005-08-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1WUM
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COMPLEX STRUCTURE OF PCAF BROMODOMAIN WITH SMALL CHEMICAL LIGAND NP2
Descriptor:Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Authors:Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., Zhou, M.M.
Deposit date:2004-12-08
Release date:2005-08-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1ZS5
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STRUCTURE-BASED EVALUATION OF SELECTIVE AND NON-SELECTIVE SMALL MOLECULES THAT BLOCK HIV-1 TAT AND PCAF ASSOCIATION
Descriptor:Histone acetyltransferase PCAF, (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
Authors:Zeng, L., Godbole, S., Muller, M., Yan, S., Sanchez, R., Zhou, M.
Deposit date:2005-05-23
Release date:2006-05-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure-based evaluation of selective nad non-selective small molecules that block hiv-1 tat and pcaf association
TO BE PUBLISHED
2KWJ
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SOLUTION STRUCTURES OF THE DOUBLE PHD FINGERS OF HUMAN TRANSCRIPTIONAL PROTEIN DPF3 BOUND TO A HISTONE PEPTIDE CONTAINING ACETYLATION AT LYSINE 14
Descriptor:Histone peptide, Zinc finger protein DPF3, ZINC ION
Authors:Zeng, L., Zhang, Q., Li, S., Plotnikov, A.N., Walsh, M.J., Zhou, M.
Deposit date:2010-04-12
Release date:2010-07-14
Last modified:2013-06-19
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010
2KWK
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SOLUTION STRUCTURES OF THE DOUBLE PHD FINGERS OF HUMAN TRANSCRIPTIONAL PROTEIN DPF3B BOUND TO A H3 PEPTIDE WILD TYPE
Descriptor:Histone peptide, Zinc finger protein DPF3, ZINC ION
Authors:Zeng, L., Zhang, Q., Li, S., Plotnikov, A.N., Walsh, M.J., Zhou, M.
Deposit date:2010-04-12
Release date:2010-07-14
Last modified:2013-06-19
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010
2KWN
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SOLUTION STRUCTURE OF THE DOUBLE PHD (PLANT HOMEODOMAIN) FINGERS OF HUMAN TRANSCRIPTIONAL PROTEIN DPF3B BOUND TO A HISTONE H4 PEPTIDE CONTAINING ACETYLATION AT LYSINE 16
Descriptor:Histone peptide, Zinc finger protein DPF3, ZINC ION
Authors:Zeng, L., Zhang, Q., Li, S., Plotnikov, A.N., Walsh, M.J., Zhou, M.
Deposit date:2010-04-13
Release date:2010-07-14
Last modified:2013-06-19
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010
2KWO
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SOLUTION STRUCTURE OF THE DOUBLE PHD (PLANT HOMEODOMAIN) FINGERS OF HUMAN TRANSCRIPTIONAL PROTEIN DPF3B BOUND TO A HISTONE H4 PEPTIDE CONTAINING N-TERMINAL ACETYLATION AT SERINE 1
Descriptor:Histone peptide, Zinc finger protein DPF3, ZINC ION
Authors:Zeng, L., Zhang, Q., Li, S., Plotnikov, A.N., Walsh, M.J., Zhou, M.
Deposit date:2010-04-14
Release date:2010-07-14
Last modified:2013-06-19
Method:SOLUTION NMR
Cite:Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b.
Nature, 466, 2010
2L5C
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SOLUTION STRUCTURES OF HUMAN PIWI-LIKE 1 PAZ DOMAIN
Descriptor:Piwi-like protein 1
Authors:Zeng, L., Zhang, Q., Yan, K., Zhou, M.
Deposit date:2010-10-29
Release date:2011-04-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Proteins, 79, 2011
2L5D
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SOLUTION STRUCTURES OF HUMAN PIWI-LIKE 1 PAZ DOMAIN WITH SSRNA (5'-PUGACA)
Descriptor:Piwi-like protein 1, 5'-R(*UP*GP*AP*CP*A)-3'
Authors:Zeng, L., Zhang, Q., Yan, K., Zhou, M.
Deposit date:2010-10-29
Release date:2011-04-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Proteins, 79, 2011
2MFQ
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NMR SOLUTION STRUCTURES OF FRS2A PTB DOMAIN WITH NEUROTROPHIN RECEPTOR TRKB
Descriptor:Fibroblast growth factor receptor substrate 2, BDNF/NT-3 growth factors receptor
Authors:Zeng, L., Zhou, M.
Deposit date:2013-10-18
Release date:2014-03-05
Last modified:2014-06-25
Method:SOLUTION NMR
Cite:Structural insights into FRS2 alpha PTB domain recognition by neurotrophin receptor TrkB.
Proteins, 82, 2014
2RNW
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THE STRUCTURAL BASIS FOR SITE-SPECIFIC LYSINE-ACETYLATED HISTONE RECOGNITION BY THE BROMODOMAINS OF THE HUMAN TRANSCRIPTIONAL CO-ACTIVATORS PCAF AND CBP
Descriptor:Histone acetyltransferase PCAF, Histone H3
Authors:Zeng, L., Zhang, Q., Gerona-Navarro, G., Zhou, M.M.
Deposit date:2008-02-03
Release date:2008-05-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16, 2008
2RNX
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THE STRUCTURAL BASIS FOR SITE-SPECIFIC LYSINE-ACETYLATED HISTONE RECOGNITION BY THE BROMODOMAINS OF THE HUMAN TRANSCRIPTIONAL CO-ACTIVATORS PCAF AND CBP
Descriptor:Histone acetyltransferase PCAF, Histone H3
Authors:Zeng, L., Zhang, Q., Gerona-Navarro, G., Zhou, M.M.
Deposit date:2008-02-03
Release date:2008-05-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16, 2008
2RNY
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COMPLEX STRUCTURES OF CBP BROMODOMAIN WITH H4 ACK20 PEPTIDE
Descriptor:CREB-binding protein, Histone H4
Authors:Zeng, L., Zhang, Q., Gerona-Navarro, G., Zhou, M.M.
Deposit date:2008-02-03
Release date:2008-05-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300
Structure, 16, 2008
2RO1
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NMR SOLUTION STRUCTURES OF HUMAN KAP1 PHD FINGER-BROMODOMAIN
Descriptor:Transcription intermediary factor 1-beta, ZINC ION
Authors:Zeng, L., Yap, K.L., Ivanov, A.V., Wang, X., Mujtaba, S., Plotnikova, O., Rauscher, F.J.
Deposit date:2008-03-04
Release date:2008-05-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
Nat.Struct.Mol.Biol., 15, 2008
3VJ6
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STRUCTURE OF THE MHC CLASS IB MOLECULE QA-1B
Descriptor:H-2 class I histocompatibility antigen, D-37 alpha chain, Beta-2-microglobulin, ...
Authors:Zeng, L., Clements, C.S., Rossjohn, J.
Deposit date:2011-10-12
Release date:2012-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b
J.Immunol., 188, 2012
2MJV
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SOLUTION STRUCTURES OF SECOND BROMODOMAIN OF BRD4 WITH DI-ACETYLATED TWIST PEPTIDE
Descriptor:Twist-related protein 1, Bromodomain-containing protein 4
Authors:Zeng, L., Zhou, M.
Deposit date:2014-01-16
Release date:2014-03-19
Method:SOLUTION NMR
Cite:Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer.
Cancer Cell, 25, 2014
2NCZ
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SOLUTION NMR STRUCTURES OF BRD4 ET DOMAIN IN COMPLEX WITH NSD3_1 PEPTIDE
Descriptor:Bromodomain-containing protein 4, Histone-lysine N-methyltransferase NSD3
Authors:Zeng, L., Zhou, M.
Deposit date:2016-04-18
Release date:2016-06-29
Last modified:2016-07-20
Method:SOLUTION NMR
Cite:Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2ND0
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SOLUTION NMR STRUCTURES OF BRD4 ET DOMAIN WITH LANA PEPTIDE
Descriptor:Bromodomain-containing protein 4, LANA
Authors:Zeng, L., Zhou, M.
Deposit date:2016-04-18
Release date:2016-06-29
Last modified:2016-07-20
Method:SOLUTION NMR
Cite:Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2ND1
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SOLUTION NMR STRUCTURES OF BRD4 ET DOMAIN IN COMPLEX WITH NSD3_3 PEPTIDE
Descriptor:Bromodomain-containing protein 4, Histone-lysine N-methyltransferase NSD3
Authors:Zeng, L., Zhou, M.
Deposit date:2016-04-19
Release date:2016-06-29
Last modified:2016-07-20
Method:SOLUTION NMR
Cite:Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2NDF
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SOLUTION NMR STRUCTURES OF AF9 YEATS DOMAIN IN COMPLEX WITH HISTON H3 ACETYLATION AT K18
Descriptor:Protein AF-9, Histone H3 peptide
Authors:Zeng, L., Zhou, M.
Deposit date:2016-05-19
Release date:2016-09-07
Last modified:2016-09-21
Method:SOLUTION NMR
Cite:Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
2NDG
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SOLUTION NMR STRUCTURES OF AF9 YEATS DOMAIN IN COMPLEX WITH HISTONE H3 CROTONYLATION AT K18
Descriptor:Protein AF-9, Histone H3 peptide
Authors:Zeng, L., Zhou, M.
Deposit date:2016-05-19
Release date:2016-09-07
Last modified:2016-09-21
Method:SOLUTION NMR
Cite:Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
5U5S
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SOLUTION STRUCTURES OF BRD2 SECOND BROMODOMAIN IN COMPLEX WITH STAT3 PEPTIDE
Descriptor:Bromodomain-containing protein 2, Stat3 peptide
Authors:Zeng, L., Zhou, M.-M.
Deposit date:2016-12-07
Release date:2017-03-22
Last modified:2019-12-04
Method:SOLUTION NMR
Cite:Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Mol. Cell, 65, 2017
5Z9C
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SOLUTION NMR STRUCTURES OF BRD4 FIRST BROMODOMAIN WITH SMALL COMPOUND MMQO
Descriptor:Bromodomain-containing protein 4, 8-methoxy-6-methylquinolin-4(1H)-one
Authors:Zeng, L., Zhou, M.-M.
Deposit date:2018-02-02
Release date:2018-02-14
Last modified:2018-05-16
Method:SOLUTION NMR
Cite:A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs.
J. Virol., 92, 2018
6MNL
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NMR SOLUTION STRUCTURES OF SECOND BROMODOMAIN OF BRD4 WITH FOXO3A PEPTIDE
Descriptor:FOXO3a peptide, Bromodomain-containing protein 4
Authors:Zeng, L., Zhou, M.-M.
Deposit date:2018-10-02
Release date:2018-10-31
Last modified:2018-12-19
Method:SOLUTION NMR
Cite:Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
1JM4
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NMR STRUCTURE OF P/CAF BROMODOMAIN IN COMPLEX WITH HIV-1 TAT PEPTIDE
Descriptor:HIV-1 Tat Peptide, P300/CBP-associated Factor
Authors:Mujtaba, S., He, Y., Zeng, L., Farooq, A., Carlson, J.E., Ott, M., Verdin, E., Zhou, M.-M.
Deposit date:2001-07-17
Release date:2002-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
Mol.Cell, 9, 2002