7WWZ

BRD4-BD1 complexed with NEO2734

Summary for 7WWZ

Entry DOI	10.2210/pdb7wwz/pdb
Descriptor	Isoform C of Bromodomain-containing protein 4, 1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethyloxy)ethyl]benzimidazol-5-yl]pyridin-2-one (3 entities in total)
Functional Keywords	brd4, bromodomain, neo2734, complex, structural protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	15403.62
Authors	Zeng, L.,Lei, J.D. (deposition date: 2022-02-14, release date: 2022-06-08, Last modification date: 2023-11-29)
Primary citation	Ji, D.,Shang, G.,Wei, E.,Jia, Y.,Wang, C.,Zhang, Q.,Zeng, L. Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer. Oncogene, 41:3251-3262, 2022 Cited by PubMed: 35513563 DOI: 10.1038/s41388-022-02327-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.16 Å)

Structure validation