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1O5T
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CRYSTAL STRUCTURE OF THE AMINOACYLATION CATALYTIC FRAGMENT OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE
Descriptor:Tryptophanyl-tRNA synthetase
Authors:Yu, Y., Liu, Y., Shen, N., Xu, X., Jia, J., Jin, Y., Arnold, E., Ding, J.
Deposit date:2003-10-05
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Human Tryptophanyl-tRNA Synthetase Catalytic Fragment
J.BIOL.CHEM., 279, 2004
3IPM
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CRYSTAL STRUCTURE OF ARCHAEAL 20S PROTEASOME IN COMPLEX WITH THE C-TERMINUS OF PAN
Descriptor:Proteasome subunit alpha, Proteasome subunit beta, Proteasome activator PA26, ...
Authors:Yu, Y., Cheng, Y.
Deposit date:2009-08-17
Release date:2009-12-29
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (4 Å)
Cite:Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions.
Embo J., 29, 2010
4HK4
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CRYSTAL STRUCTURE OF APO TYROSINE-TRNA LIGASE MUTANT PROTEIN
Descriptor:Tyrosine--tRNA ligase, DI(HYDROXYETHYL)ETHER
Authors:Yu, Y., Zhou, Q., Dong, J., Li, J., Xiaoxuan, L., Mukherjee, A., Ouyang, H., Nilges, M., Li, H., Gao, F., Gong, W., Lu, Y., Wang, J.
Deposit date:2012-10-15
Release date:2013-04-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Crystal structure of apo Tyrosine-tRNA ligase mutant protein
To be Published
4HPW
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CRYSTAL STRUCTURE OF TYROSINE-TRNA LIGASE MUTANT COMPLEXED WITH UNNATURAL AMINO ACID 3-O-METHYL-TYROSINE
Descriptor:Tyrosine--tRNA ligase, 3-methoxy-L-tyrosine
Authors:Yu, Y., Zhou, Q., Dong, J., Li, J., Xiaoxuan, L., Mukherjee, A., Ouyang, H., Nilges, M., Li, H., Gao, F., Gong, W., Lu, Y., Wang, J.
Deposit date:2012-10-24
Release date:2013-10-30
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Crystal structure of Tyrosine-tRNA ligase mutant complexed with unnatural amino acid 3-o-methyl-Tyrosine
To be Published
1XTQ
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STRUCTURE OF SMALL GTPASE HUMAN RHEB IN COMPLEX WITH GDP
Descriptor:GTP-binding protein Rheb, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Yu, Y., Ding, J.
Deposit date:2004-10-24
Release date:2005-03-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
1XTR
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STRUCTURE OF SMALL GTPASE HUMAN RHEB IN COMPLEX WITH GPPNHP
Descriptor:GTP-binding protein Rheb, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Yu, Y., Ding, J.
Deposit date:2004-10-24
Release date:2005-03-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
1XTS
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STRUCTURE OF SMALL GTPASE HUMAN RHEB IN COMPLEX WITH GTP
Descriptor:GTP-binding protein Rheb, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Yu, Y., Ding, J.
Deposit date:2004-10-24
Release date:2005-03-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
4M58
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CRYSTAL STRUCTURE OF AN TRANSITION METAL TRANSPORTER
Descriptor:Cobalamin biosynthesis protein CbiM, NICKEL (II) ION
Authors:Yu, Y., Yan, C.Y., Zhang, B., Li, X.L., Gu, J.K.
Deposit date:2013-08-08
Release date:2014-03-26
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters
Cell Res., 24, 2014
4M5B
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CRYSTAL STRUCTURE OF AN TRUNCATED TRANSITION METAL TRANSPORTER
Descriptor:Cobalamin biosynthesis protein CbiM, HEXANE-1,6-DIOL, NICKEL (II) ION
Authors:Yu, Y.
Deposit date:2013-08-08
Release date:2014-03-26
Method:X-RAY DIFFRACTION (1.833 Å)
Cite:Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters
Cell Res., 24, 2014
4M5C
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CRYSTAL STRUCTURE OF AN TRUNCATED TRANSITION METAL TRANSPORTER
Descriptor:Cobalamin biosynthesis protein CbiM, COBALT (II) ION, HEXANE-1,6-DIOL
Authors:Yu, Y., Zhou, M.Z., Gu, J.K.
Deposit date:2013-08-08
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters
Cell Res., 24, 2014
2G3F
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CRYSTAL STRUCTURE OF IMIDAZOLONEPROPIONASE COMPLEXED WITH IMIDAZOLE-4-ACETIC ACID SODIUM SALT, A SUBSTRATE HOMOLOGUE
Descriptor:Imidazolonepropionase, ZINC ION, 2H-IMIDAZOL-4-YLACETIC ACID
Authors:Yu, Y., Liang, Y.H., Su, X.D.
Deposit date:2006-02-19
Release date:2006-09-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis
J.Biol.Chem., 281, 2006
3HRN
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CRYSTAL STRUCTURE OF A C-TERMINAL COILED COIL DOMAIN OF TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL SUBFAMILY P MEMBER 2 (TRPP2, POLYCYSTIC KIDNEY DISEASE 2)
Descriptor:Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2)
Authors:Yu, Y., Ulbrich, M.H., Li, M.-H., Buraei, Z., Chen, X.-Z., Ong, A.C.M., Tong, L., Isacoff, E.Y., Yang, J.
Deposit date:2009-06-09
Release date:2009-07-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
3HRO
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CRYSTAL STRUCTURE OF A C-TERMINAL COILED COIL DOMAIN OF TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL SUBFAMILY P MEMBER 2 (TRPP2, POLYCYSTIC KIDNEY DISEASE 2)
Descriptor:Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2), also called Polycystin-2 or polycystic kidney disease 2(PKD2)
Authors:Yu, Y., Ulbrich, M.H., Li, M.-H., Buraei, Z., Chen, X.-Z., Ong, A.C.M., Tong, L., Isacoff, E.Y., Yang, J.
Deposit date:2009-06-09
Release date:2009-07-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
3V4P
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT-1
Descriptor:Integrin alpha-4, Integrin beta-7, MONOCLONAL ANTIBODY Act-1 HEAVY CHAIN, ...
Authors:Yu, Y., Zhu, J., Springer, T.A.
Deposit date:2011-12-15
Release date:2012-01-11
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
3V4V
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB ACT-1 AND RO0505376
Descriptor:Integrin alpha-4, Integrin beta-7, MONOCLONAL ANTIBODY Act-1 HEAVY CHAIN, ...
Authors:Yu, Y., Zhu, J., Springer, T.A.
Deposit date:2011-12-15
Release date:2012-01-11
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
4B2H
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COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS
Descriptor:DODECIN, SODIUM ION, SULFATE ION, ...
Authors:Yu, Y., Heidel, B., Parapugna, T.L., Wenderhold-Reeb, S., Song, B., Schoenherr, H., Grininger, M., Noell, G.
Deposit date:2012-07-16
Release date:2013-05-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Flavoprotein Dodecin as a Redox Probe for Electron Transfer Through DNA.
Angew.Chem.Int.Ed.Engl., 52, 2013
4GIF
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C-TERMINAL COILED-COIL DOMAIN OF TRANSIENT RECEPTOR POTENTIAL CHANNEL TRPP3 (PKD2L1, POLYCYSTIN-L)
Descriptor:Polycystic kidney disease 2-like 1 protein
Authors:Yu, Y., Ulbrich, M.H., Li, M.-H., Dobbins, S., Zhang, W.K., Tong, L., Isacoff, E.Y., Yang, J.
Deposit date:2012-08-08
Release date:2012-12-05
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex.
Nat Commun, 3, 2012
4IRZ
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CRYSTAL STRUCTURE OF A4B7 HEADPIECE COMPLEXED WITH FAB NATALIZUMAB
Descriptor:Integrin alpha4 subunit, Fab Natalizumab light chain, Fab Natalizumab heavy chain, ...
Authors:Yu, Y., Schurpf, T., Springer, T.A.
Deposit date:2013-01-15
Release date:2013-09-25
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:How natalizumab binds and antagonizes alpha 4 integrins.
J.Biol.Chem., 288, 2013
5JWA
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THE STRUCTURE OF MALARIA PFNDH2
Descriptor:NADH dehydrogenase, putative, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Yu, Y., Yang, Y.Q., Li, X.L., Yu, J., Ge, J.P., Li, J., Rao, Y., Yang, M.J.
Deposit date:2016-05-11
Release date:2017-03-22
Method:X-RAY DIFFRACTION (2.162 Å)
Cite:Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
5JWB
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STRUCTURE OF NDH2 FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH NADH
Descriptor:Type II NADH:ubiquinone oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Yu, Y., Li, X.L.
Deposit date:2016-05-12
Release date:2017-03-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
5JWC
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STRUCTURE OF NDH2 FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH RYL-552
Descriptor:NADH dehydrogenase, putative, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Yu, Y.
Deposit date:2016-05-12
Release date:2017-03-22
Method:X-RAY DIFFRACTION (2.051 Å)
Cite:Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
5XHS
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CRYSTAL STRUCTURE OF SIRT5 COMPLEXED WITH A FLUOROGENIC SMALL-MOLECULE SUBSTRATE SUBKA
Descriptor:NAD-dependent protein deacylase sirtuin-5, mitochondrial, benzyl chlorocarbonate, ...
Authors:Yu, Y., Li, B., Chen, Q.
Deposit date:2017-04-24
Release date:2018-05-02
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design
Rsc Adv, 7, 2017
5XLZ
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THE CRYSTAL STRUCTURE OF TUBULIN COMPLEXED WITH A BENZYLIDENE DERIVATIVE OF 9(10H)-ANTHRACENONE
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Yu, Y., Chen, Q.
Deposit date:2017-05-12
Release date:2017-11-22
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structure of a benzylidene derivative of 9(10H)-anthracenone in complex with tubulin provides a rationale for drug design.
Biochem. Biophys. Res. Commun., 495, 2018
5XLT
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THE CRYSTAL STRUCTURE OF TUBULIN IN COMPLEX WITH 4'-DEMETHYLEPIPODOPHYLLOTOXIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Yu, Y., Chen, Q.
Deposit date:2017-05-11
Release date:2017-09-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design
Biochem. Biophys. Res. Commun., 493, 2017
2BB0
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STRUCTURE OF IMIDAZOLONEPROPIONASE FROM BACILLUS SUBTILIS
Descriptor:Imidazolonepropionase, ACETATE ION, ZINC ION
Authors:Liang, Y.H., Yu, Y., Su, X.D.
Deposit date:2005-10-16
Release date:2006-09-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis
J.Biol.Chem., 281, 2006