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1SKO
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BU of 1sko by Molmil
MP1-p14 Complex
Descriptor: Late endosomal/lysosomal Mp1 interacting protein, Mitogen-activated protein kinase kinase 1 interacting protein 1
Authors:Lunin, V.V, Munger, C, Wagner, J, Ye, Z, Cygler, M, Sacher, M.
Deposit date:2004-03-05
Release date:2004-06-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of the MAP kinase scaffold MP1 bound to its partner p14: a complex with a critical role in endosomal MAP kinase signaling
J.Biol.Chem., 279, 2004
8GXF
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BU of 8gxf by Molmil
Pseudomonas flexibilis GCN5 family acetyltransferase
Descriptor: COENZYME A, GCN5 family acetyltransferase
Authors:Song, Y.J, Bao, R.
Deposit date:2022-09-20
Release date:2022-10-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:The novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur.
Nucleic Acids Res., 50, 2022
8GXJ
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BU of 8gxj by Molmil
Pseudomonas aeruginosa N-acetyltransferase domain-containing protein PA3270
Descriptor: N-acetyltransferase domain-containing protein
Authors:Song, Y.J, Bao, R.
Deposit date:2022-09-20
Release date:2022-10-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:The novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur.
Nucleic Acids Res., 50, 2022
6OAL
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BU of 6oal by Molmil
Structure of human PARG complexed with JA2120
Descriptor: 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Brosey, C.A, Ahmed, Z, Warden, S, Tainer, J.A.
Deposit date:2019-03-16
Release date:2020-03-18
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OAK
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BU of 6oak by Molmil
Structure of human PARG complexed with JA2131
Descriptor: (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Brosey, C.A, Ahmed, Z, Warden, S, Tainer, J.A.
Deposit date:2019-03-16
Release date:2020-03-18
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA3
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BU of 6oa3 by Molmil
Structure of human PARG complexed with JA2131
Descriptor: (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6O9Y
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BU of 6o9y by Molmil
Structure of human PARG complexed with JA2-8
Descriptor: 7-[(2S)-2-hydroxy-3-(morpholin-4-yl)propyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA0
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BU of 6oa0 by Molmil
Structure of human PARG complexed with JA2-9
Descriptor: 4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)butanoic acid, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6O9X
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BU of 6o9x by Molmil
Structure of human PARG complexed with JA2-4
Descriptor: 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA1
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BU of 6oa1 by Molmil
Structure of human PARG complexed with JA2120
Descriptor: 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
7KCF
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BU of 7kcf by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AGI-24512
Descriptor: 1,2-ETHANEDIOL, 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one, GLYCEROL, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-05
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KDA
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BU of 7kda by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 34
Descriptor: 2,3-diphenyl-5-[(1H-pyrazol-3-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-08
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KDB
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BU of 7kdb by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 35
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-(4-hydroxyphenyl)-2,3-diphenyl-5-[(1H-pyrazol-3-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-08
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KCC
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BU of 7kcc by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AG-270
Descriptor: 1,2-ETHANEDIOL, 3-(cyclohex-1-en-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-[(pyridin-2-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-05
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KCE
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BU of 7kce by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 2
Descriptor: 5-methyl-2,3-diphenylpyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, S-ADENOSYLMETHIONINE, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-05
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
3LD1
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BU of 3ld1 by Molmil
Crystal Structure of IBV Nsp2a
Descriptor: Replicase polyprotein 1a
Authors:Xu, Y, Cong, L, Wei, L, Fu, J, Chen, C, Yang, A, Tang, H, Bartlam, M, Rao, Z.
Deposit date:2010-01-12
Release date:2011-05-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:IBV nsp2 is an endosome-associated protein and viral pathogenicity factor
To be Published
5V7S
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BU of 5v7s by Molmil
Crystal structure of Influenza A virus matrix protein M1 (NLS-88E, pH 6.2)
Descriptor: Matrix protein 1, PHOSPHATE ION
Authors:Musayev, F.N, Safo, M.K, Althufairi, B, Desai, U.R, Xie, H, Mosier, P.D, Chiang, M.-J, Zhou, Q.
Deposit date:2017-03-20
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V6G
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BU of 5v6g by Molmil
Crystal structure of Influenza A virus Matrix Protein M1(NLS-88R)
Descriptor: Matrix protein 1
Authors:Musayev, F.N, Safo, M.K, Desai, U.R, Xie, H, Mosier, P.D, Chiang, M.-J.
Deposit date:2017-03-16
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V8A
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BU of 5v8a by Molmil
Crystal structure of Influenza A virus matrix protein M1 (NLS-88R, pH 7.3)
Descriptor: Matrix protein 1
Authors:Musayev, F.N, Safo, M.K, Desai, U.R, Xie, H, Mosier, P.D, Zhou, Q, Chiang, M.-J, Kosikova, M.
Deposit date:2017-03-21
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V7B
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BU of 5v7b by Molmil
Crystal structure of Influenza A virus matrix protein M1 (NLS-88E)
Descriptor: Matrix protein 1
Authors:Musayev, F.N, Safo, M.K, Desai, U.R, Xie, H, Mosier, P.D, Chiang, M.-J.
Deposit date:2017-03-20
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
6DDR
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BU of 6ddr by Molmil
Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody
Descriptor: Anti-MICA Fab fragment heavy chain clone 13A9, Anti-MICA Fab fragment light chain clone 13A9, GLYCEROL, ...
Authors:Matsumoto, M.L.
Deposit date:2018-05-10
Release date:2018-10-24
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
MAbs, 11, 2019
6DDM
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BU of 6ddm by Molmil
Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody
Descriptor: Anti-MICA Fab fragment heavy chain clone 1D5, Anti-MICA Fab fragment light chain clone 1D5, MHC class I polypeptide-related sequence A
Authors:Matsumoto, M.L.
Deposit date:2018-05-10
Release date:2018-10-24
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
MAbs, 11, 2019
6DDV
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BU of 6ddv by Molmil
Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody
Descriptor: Anti-MICA Fab fragment heavy chain clone 6E1, Anti-MICA Fab fragment light chain clone 6E1, MHC class I chain-related protein A
Authors:Matsumoto, M.L.
Deposit date:2018-05-10
Release date:2018-10-24
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
MAbs, 11, 2019
4ZSE
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BU of 4zse by Molmil
Crystal structure of EGFR 696-1022 T790M/V948R, crystal form II
Descriptor: 1,2-ETHANEDIOL, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Yan, X.E, Yun, C.H.
Deposit date:2015-05-13
Release date:2016-06-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Ibrutinib Selectively and Irreversibly Targets EGFR-mutant non-Small Cell Lung Cancer Cells
To Be Published
8K60
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BU of 8k60 by Molmil
Cryo-EM structure of Streptomyces coelicolor transcription initiation complex with the global transcription factor AfsR
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lin, W, Shi, J.
Deposit date:2023-07-24
Release date:2024-07-31
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural insights into transcription activation of the Streptomyces antibiotic regulatory protein, AfsR.
Iscience, 27, 2024

 

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