1SKO | | MP1-P14 COMPLEX | | Descriptor: | Mitogen-activated protein kinase kinase 1 interacting protein 1, Late endosomal/lysosomal Mp1 interacting protein | | Authors: | Lunin, V.V., Munger, C., Wagner, J., Ye, Z., Cygler, M., Sacher, M. | | Deposit date: | 2004-03-05 | | Release date: | 2004-06-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structure of the MAP kinase scaffold MP1 bound to its partner p14: a complex with a critical role in endosomal MAP kinase signaling
J.Biol.Chem., 279, 2004
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3LD1 | | CRYSTAL STRUCTURE OF IBV NSP2A | | Descriptor: | Replicase polyprotein 1a | | Authors: | Xu, Y., Cong, L., Wei, L., Fu, J., Chen, C., Yang, A., Tang, H., Bartlam, M., Rao, Z. | | Deposit date: | 2010-01-12 | | Release date: | 2011-05-25 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2.498 Å) | | Cite: | IBV nsp2 is an endosome-associated protein and viral pathogenicity factor
To be Published
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5GRD | | CRYSTAL STRUCTURE OF 10-MER PEPTIDE FROM EBV IN COMPLEX WITH HLA-A1101. | | Descriptor: | HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ... | | Authors: | Tadwal, V.S., Xiao, Z., Ren, E.C. | | Deposit date: | 2016-08-10 | | Release date: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
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5GRG | | CRYSTAL STRUCTURE OF DUAL PEPTIDE FROM EBV IN COMPLEX WITH HLA-A*11:01 | | Descriptor: | HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ... | | Authors: | Tadwal, V.S., Xiao, Z., Ren, E.C. | | Deposit date: | 2016-08-11 | | Release date: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
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5GSD | | CRYSTAL STRUCTURE OF LMP2 PEPTIDE FROM EBV IN COMPLEX WITH HLA-A*11:01 | | Descriptor: | HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ... | | Authors: | Tadwal, V.S., Xiao, Z., Ren, E.C. | | Deposit date: | 2016-08-15 | | Release date: | 2017-08-09 | | Last modified: | 2017-09-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
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6OAK | | STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2131 | | Descriptor: | Poly(ADP-ribose) glycohydrolase, (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one | | Authors: | Brosey, C.A., Ahmed, Z., Warden, S., Tainer, J.A. | | Deposit date: | 2019-03-16 | | Release date: | 2020-03-18 | | Last modified: | 2020-05-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6OAL | | STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2120 | | Descriptor: | Poly(ADP-ribose) glycohydrolase, 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione | | Authors: | Brosey, C.A., Ahmed, Z., Warden, S., Tainer, J.A. | | Deposit date: | 2019-03-16 | | Release date: | 2020-03-18 | | Last modified: | 2020-05-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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4ZSE | |
5V6G | | CRYSTAL STRUCTURE OF INFLUENZA A VIRUS MATRIX PROTEIN M1(NLS-88R) | | Descriptor: | Matrix protein 1 | | Authors: | Musayev, F.N., Safo, M.K., Desai, U.R., Xie, H., Mosier, P.D., Chiang, M.-J. | | Deposit date: | 2017-03-16 | | Release date: | 2017-04-12 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
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5V7B | | CRYSTAL STRUCTURE OF INFLUENZA A VIRUS MATRIX PROTEIN M1 (NLS-88E) | | Descriptor: | Matrix protein 1 | | Authors: | Musayev, F.N., Safo, M.K., Desai, U.R., Xie, H., Mosier, P.D., Chiang, M.-J. | | Deposit date: | 2017-03-20 | | Release date: | 2017-04-12 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
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5V7S | | CRYSTAL STRUCTURE OF INFLUENZA A VIRUS MATRIX PROTEIN M1 (NLS-88E, PH 6.2) | | Descriptor: | Matrix protein 1, PHOSPHATE ION | | Authors: | Musayev, F.N., Safo, M.K., Althufairi, B., Desai, U.R., Xie, H., Mosier, P.D., Chiang, M.-J., Zhou, Q. | | Deposit date: | 2017-03-20 | | Release date: | 2017-04-12 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
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5V8A | | CRYSTAL STRUCTURE OF INFLUENZA A VIRUS MATRIX PROTEIN M1 (NLS-88R, PH 7.3) | | Descriptor: | Matrix protein 1 | | Authors: | Musayev, F.N., Safo, M.K., Desai, U.R., Xie, H., Mosier, P.D., Zhou, Q., Chiang, M.-J., Kosikova, M. | | Deposit date: | 2017-03-21 | | Release date: | 2017-04-19 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
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5YU9 | | CRYSTAL STRUCTURE OF EGFR 696-1022 T790M IN COMPLEX WITH IBRUTINIB | | Descriptor: | Epidermal growth factor receptor, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, CHLORIDE ION | | Authors: | Yan, X.E., Yun, C.H. | | Deposit date: | 2017-11-21 | | Release date: | 2017-12-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation.
Oncotarget, 7, 2016
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6O9X | | STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2-4 | | Descriptor: | Poly(ADP-ribose) glycohydrolase, 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one | | Authors: | Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A. | | Deposit date: | 2019-03-15 | | Release date: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6O9Y | | STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2-8 | | Descriptor: | Poly(ADP-ribose) glycohydrolase, 7-[(2S)-2-hydroxy-3-(morpholin-4-yl)propyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione | | Authors: | Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A. | | Deposit date: | 2019-03-15 | | Release date: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6OA0 | | STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2-9 | | Descriptor: | Poly(ADP-ribose) glycohydrolase, 4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)butanoic acid | | Authors: | Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A. | | Deposit date: | 2019-03-15 | | Release date: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6OA1 | | STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2120 | | Descriptor: | Poly(ADP-ribose) glycohydrolase, 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione | | Authors: | Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A. | | Deposit date: | 2019-03-15 | | Release date: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6OA3 | | STRUCTURE OF HUMAN PARG COMPLEXED WITH JA2131 | | Descriptor: | Poly(ADP-ribose) glycohydrolase, (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one | | Authors: | Stegeman, R.A., Jones, D.E., Ellenberger, T., Kim, I.K., Tainer, J.A. | | Deposit date: | 2019-03-15 | | Release date: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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1O77 | | CRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2 | | Descriptor: | TOLL-LIKE RECEPTOR 2 | | Authors: | Tao, X., Xu, Y., Ye, Z., Beg, A.A., Tong, L. | | Deposit date: | 2002-10-24 | | Release date: | 2002-11-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | An Extensively Associated Dimer in the Structure of the C713S Mutant of the Tir Domain of Human Tlr2
Biochem.Biophys.Res.Commun., 299, 2002
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1XHN | |
3QOD | | CRYSTAL STRUCTURE OF HETEROCYST DIFFERENTIATION PROTEIN, HETR FROM FISCHERELLA MV11 | | Descriptor: | Heterocyst differentiation protein | | Authors: | Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2011-02-09 | | Release date: | 2011-04-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.38 Å) | | Cite: | Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3QOE | | CRYSTAL STRUCTURE OF HETEROCYST DIFFERENTIATION PROTEIN, HETR FROM FISCHERELLA MV11 | | Descriptor: | Heterocyst differentiation protein | | Authors: | Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2011-02-09 | | Release date: | 2011-04-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.004 Å) | | Cite: | Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4IZZ | | CRYSTAL STRUCTURE OF FISCHERELLA TRANSCRIPTION FACTOR HETR COMPLEXED WITH 21MER DNA TARGET | | Descriptor: | Transcription Factor HetR, DNA (5'-D(*GP*TP*GP*AP*GP*GP*GP*GP*TP*TP*AP*AP*AP*CP*CP*CP*CP*TP*CP*AP*C)-3'), SULFATE ION, ... | | Authors: | Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., MCSG, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2013-01-30 | | Release date: | 2013-03-27 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.502 Å) | | Cite: | Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4J00 | | CRYSTAL STRUCTURE OF FISCHERELLA TRANSCRIPTION FACTOR HETR COMPLEXED WITH 24MER DNA TARGET | | Descriptor: | Transcription Factor HetR, DNA (5'-D(*TP*GP*GP*TP*GP*AP*GP*GP*GP*GP*TP*TP*AP*AP*AP*CP*CP*CP*CP*TP*CP*AP*CP*C)-3'), MAGNESIUM ION | | Authors: | Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., MCSG, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2013-01-30 | | Release date: | 2013-03-27 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (3.004 Å) | | Cite: | Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4J01 | | CRYSTAL STRUCTURE OF FISCHERELLA TRANSCRIPTION FACTOR HETR COMPLEXED WITH 29MER DNA TARGET | | Descriptor: | Transcription Factor HetR, DNA (29-MER), SULFATE ION | | Authors: | Kim, Y., Joachimiak, G., Gornicki, P., Joachimiak, A., MCSG, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2013-01-30 | | Release date: | 2013-03-27 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (3.246 Å) | | Cite: | Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets.
Proc.Natl.Acad.Sci.USA, 110, 2013
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