Structure of human PARG complexed with JA2-4

Summary for 6O9X

DescriptorPoly(ADP-ribose) glycohydrolase, 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one (3 entities in total)
Functional Keywordshydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight61549.09
Stegeman, R.A.,Jones, D.E.,Ellenberger, T.,Kim, I.K.,Tainer, J.A. (deposition date: 2019-03-15, release date: 2019-12-25)
Primary citation
Houl, J.H.,Ye, Z.,Brosey, C.A.,Balapiti-Modarage, L.P.F.,Namjoshi, S.,Bacolla, A.,Laverty, D.,Walker, B.L.,Pourfarjam, Y.,Warden, L.S.,Babu Chinnam, N.,Moiani, D.,Stegeman, R.A.,Chen, M.K.,Hung, M.C.,Nagel, Z.D.,Ellenberger, T.,Kim, I.K.,Jones, D.E.,Ahmed, Z.,Tainer, J.A.
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10:5654-5654, 2019
PubMed: 31827085 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-13508-4
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2032 0.2% 1.4% 8.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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