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6O9X

Structure of human PARG complexed with JA2-4

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1APoly(ADP-ribose) glycohydrolasepolymer53361223.61UniProt (Q86W56)
Pfam (PF20811)
Pfam (PF05028)
In PDB
Homo sapiens (Human)
2A1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-onenon-polymer325.51Chemie (M0S)
3waterwater18.0409Chemie (HOH)
Sequence modifications
A: 448 - 976 (UniProt: Q86W56)
PDBExternal DatabaseDetails
Gly 444-expression tag
Pro 445-expression tag
His 446-expression tag
Met 447-expression tag
Ala 616Lys 616engineered mutation
Ala 617Gln 617engineered mutation
Ala 618Lys 618engineered mutation
Ala 688Glu 688engineered mutation
Ala 689Lys 689engineered mutation
Ala 690Lys 690engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight61223.6
Non-Polymers*Number of molecules1
Total formula weight325.5
All*Total formula weight61549.1
*Water molecules are not included.

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PDB entries from 2024-03-27

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