7KCE

Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 2

Summary for 7KCE

• Entry DOI: 10.2210/pdb7kce/pdb
• Related: 7KCC 7KCF 7KDA 7KDB
• Descriptor: S-adenosylmethionine synthase isoform type-2, 5-methyl-2,3-diphenylpyrazolo[1,5-a]pyrimidin-7(4H)-one, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• Functional Keywords: methionine adenosyltransferase, s-adenosylmethionine synthase isoform type-2, sam, allosteric inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 44542.93

Authors

Padyana, A.,Jin, L. (deposition date: 2020-10-05, release date: 2021-04-21, Last modification date: 2023-10-18)

• Primary citation: Konteatis, Z.,Travins, J.,Gross, S.,Marjon, K.,Barnett, A.,Mandley, E.,Nicolay, B.,Nagaraja, R.,Chen, Y.,Sun, Y.,Liu, Z.,Yu, J.,Ye, Z.,Jiang, F.,Wei, W.,Fang, C.,Gao, Y.,Kalev, P.,Hyer, M.L.,DeLaBarre, B.,Jin, L.,Padyana, A.K.,Dang, L.,Murtie, J.,Biller, S.A.,Sui, Z.,Marks, K.M.; Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.; J.Med.Chem., 64:4430-4449, 2021; PubMed: 33829783; DOI: 10.1021/acs.jmedchem.0c01895

Experimental method

X-RAY DIFFRACTION (1.14 Å)