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3J79
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, LARGE SUBUNIT
Descriptor:28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-02
Release date:2014-07-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3J7A
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, SMALL SUBUNIT
Descriptor:18S ribosomal RNA, 40S ribosomal protein eS1, 40S ribosomal protein uS2, ...
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-03
Release date:2014-07-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3Q2B
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CRYSTAL STRUCTURE OF AN ACTIN DEPOLYMERIZING FACTOR
Descriptor:Cofilin/actin-depolymerizing factor homolog 1, BETA-MERCAPTOETHANOL, D(-)-TARTARIC ACID
Authors:Wong, W., Clarke, O.B., Gulbis, J.M., Baum, J.
Deposit date:2010-12-19
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1
Proc.Natl.Acad.Sci.USA, 108, 2011
3TI7
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CRYSTAL STRUCTURE OF THE BASIC PROTEASE BPRV FROM THE OVINE FOOTROT PATHOGEN, DICHELOBACTER NODOSUS
Descriptor:Basic extracellular subtilisin-like protease BprV, CALCIUM ION
Authors:Wong, W., Whisstock, J.C., Porter, C.J.
Deposit date:2011-08-20
Release date:2011-10-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction.
J.Biol.Chem., 286, 2011
3TI9
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CRYSTAL STRUCTURE OF THE BASIC PROTEASE BPRB FROM THE OVINE FOOTROT PATHOGEN, DICHELOBACTER NODOSUS
Descriptor:Serine protease, CALCIUM ION, GLYCEROL, ...
Authors:Wong, W., Whisstock, J.C., Porter, C.J.
Deposit date:2011-08-20
Release date:2011-10-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction.
J.Biol.Chem., 286, 2011
5UMD
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STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTIMALARIAL DRUG MEFLOQUINE
Descriptor:28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Wong, W., Bai, X.-C., Brown, A., Scheres, S., Baum, J.
Deposit date:2017-01-27
Release date:2017-03-01
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Nat Microbiol, 2, 2017
3LPA
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CRYSTAL STRUCTURE OF A SUBTILISIN-LIKE PROTEASE
Descriptor:Acidic extracellular subtilisin-like protease AprV2, CALCIUM ION
Authors:Porter, C.J., Wong, W., Whisstock, J.C., Rood, J.I., Kennan, R.M.
Deposit date:2010-02-05
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Plos Pathog., 6, 2010
3LPC
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CRYSTAL STRUCTURE OF A SUBTILISIN-LIKE PROTEASE
Descriptor:AprB2, CALCIUM ION, ACETATE ION, ...
Authors:Porter, C.J., Wong, W., Whisstock, J.C., Rood, J.I., Kennan, R.M.
Deposit date:2010-02-05
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Plos Pathog., 6, 2010
3LPD
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CRYSTAL STRUCTURE OF A SUBTILISIN-LIKE PROTEASE
Descriptor:Acidic extracellular subtilisin-like protease AprV2, CALCIUM ION
Authors:Porter, C.J., Wong, W., Whisstock, J.C., Rood, J.I., Kennan, R.M.
Deposit date:2010-02-05
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Plos Pathog., 6, 2010
2QP2
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STRUCTURE OF A MACPF/PERFORIN-LIKE PROTEIN
Descriptor:Unknown protein, CALCIUM ION
Authors:Rosado, C.J., Buckle, A.M., Law, R.H.P., Butcher, R.E., Kan, W.T., Bird, C.H., Ung, K., Browne, K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike, R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J., Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., Whisstock, J.C.
Deposit date:2007-07-22
Release date:2007-09-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:A common fold mediates vertebrate defense and bacterial attack
Science, 317, 2007
4N92
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CRYSTAL STRUCTURE OF BETA-LACTAMSE PENP_E166S
Descriptor:Beta-lactamase
Authors:Pan, X., Wong, W., Zhao, Y.
Deposit date:2013-10-19
Release date:2014-09-10
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
4N9K
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CRYSTAL STRUCTURE OF BETA-LACTAMSE PENP_E166S IN COMPLEX WITH CEPHALORIDINE
Descriptor:Beta-lactamase, 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID
Authors:Pan, X., Wong, W., Zhao, Y.
Deposit date:2013-10-21
Release date:2014-09-10
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
4N9L
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CRYSTAL STRUCTURE OF BETA-LACTAMSE PENP_E166S IN COMPLEX WITH MEROPENEM
Descriptor:Beta-lactamase, (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid
Authors:Pan, X., Wong, W., Zhao, Y.
Deposit date:2013-10-21
Release date:2014-09-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
6MPV
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CRYO-ELECTRON MICROSCOPY STRUCTURE OF PLASMODIUM FALCIPARUM RH5/CYRPA/RIPR INVASION COMPLEX
Descriptor:Cysteine-rich protective antigen, Reticulocyte binding protein 5, PfRipr
Authors:Wilson, W., Zhiheng, Y., Cowman, A.F.
Deposit date:2018-10-08
Release date:2018-12-12
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (7.17 Å)
Cite:Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.
Nature, 565, 2019
5TIH
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STRUCTURAL BASIS FOR INHIBITION OF ERYTHROCYTE INVASION BY ANTIBODIES TO PLASMODIUM FALCIPARUM PROTEIN CYRPA
Descriptor:Cysteine-rich protective antigen, CyRPA antibody Fab Heavy Chain, CyRPA antibody Fab Light Chain, ...
Authors:Chen, L., Xu, Y., Wang, W., Thompson, J.K., Goddard-Borger, E., Lawrence, M.C., Cowman, A.F.
Deposit date:2016-10-03
Release date:2017-03-01
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural basis for inhibition of erythrocyte invasion by antibodies toPlasmodium falciparumprotein CyRPA.
Elife, 6, 2017
5TIK
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STRUCTURAL BASIS FOR INHIBITION OF ERYTHROCYTE INVASION BY ANTIBODIES TO PLASMODIUM FALCIPARUM PROTEIN CYRPA
Descriptor:Cysteine-rich protective antigen
Authors:Chen, L., Xu, Y., Wang, W., Thompson, J.K., Goddard-Borger, E., Lawrence, M.C., Cowman, A.F.
Deposit date:2016-10-03
Release date:2017-03-01
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structural basis for inhibition of erythrocyte invasion by antibodies toPlasmodium falciparumprotein CyRPA.
Elife, 6, 2017
3VPP
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CRYSTAL STRUCTURE OF THE HUMAN CLEC9A C-TYPE LECTIN-LIKE DOMAIN
Descriptor:C-type lectin domain family 9 member A, CALCIUM ION
Authors:Czabotar, P.E., Zhang, J.G., Policheni, A.N., Shortman, K., Lahoud, M.H., Colman, P.M.
Deposit date:2012-03-07
Release date:2012-04-25
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.642 Å)
Cite:The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity, 36, 2012
6BPA
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PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2B) BOUND TO MONOCLONAL ANTIBODY 3E9
Descriptor:Reticulocyte binding protein 2, putative, Monoclonal antibody 3E9 Fab heavy chain, ...
Authors:Gruszczyk, J., Chan, L.J., Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6BPB
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PLASMODIUM VIVAX INVASION BLOCKING MONOCLONAL ANTIBODY 4F7
Descriptor:Monoclonal antibody 4F7 Fab heavy chain, Monoclonal antibody 4F7 Fab light chain
Authors:Gruszczyk, J., Chan, L.J., Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6BPC
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PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2B) BOUND TO MONOCLONAL ANTIBODY 4F7
Descriptor:Reticulocyte binding protein 2, putative, Monoclonal antibody 4F7 Fab heavy chain, ...
Authors:Gruszczyk, J., Chan, L.J., Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6BPD
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PLASMODIUM VIVAX INVASION BLOCKING MONOCLONAL ANTIBODY 10B12
Descriptor:Monoclonal antibody 10B12 Fab heavy chain, Monoclonal antibody 10B12 Fab light chain
Authors:Gruszczyk, J., Chan, L.J., Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6BPE
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PLASMODIUM VIVAX RETICULOCYTE BINDING PROTEIN 2B (PVRBP2B) BOUND TO MONOCLONAL ANTIBODY 6H1
Descriptor:Reticulocyte binding protein 2, putative, Monoclonal antibody 6H1 Fab heavy chain, ...
Authors:Gruszczyk, J., Chan, L.J., Tham, W.H.
Deposit date:2017-11-22
Release date:2018-06-20
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6D03
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CRYO-EM STRUCTURE OF A PLASMODIUM VIVAX INVASION COMPLEX ESSENTIAL FOR ENTRY INTO HUMAN RETICULOCYTES; ONE MOLECULE OF PARASITE LIGAND.
Descriptor:Transferrin receptor protein 1, Serotransferrin, Reticulocyte binding protein 2, ...
Authors:Gruszczyk, J., Huang, R.K., Hong, C., Yu, Z., Tham, W.H.
Deposit date:2018-04-10
Release date:2018-06-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6D04
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CRYO-EM STRUCTURE OF A PLASMODIUM VIVAX INVASION COMPLEX ESSENTIAL FOR ENTRY INTO HUMAN RETICULOCYTES; TWO MOLECULES OF PARASITE LIGAND, SUBCLASS 1.
Descriptor:Transferrin receptor protein 1, Serotransferrin, Reticulocyte binding protein 2, ...
Authors:Gruszczyk, J., Huang, R.K., Hong, C., Yu, Z., Tham, W.H.
Deposit date:2018-04-10
Release date:2018-06-20
Last modified:2018-07-11
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
6D05
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CRYO-EM STRUCTURE OF A PLASMODIUM VIVAX INVASION COMPLEX ESSENTIAL FOR ENTRY INTO HUMAN RETICULOCYTES; TWO MOLECULES OF PARASITE LIGAND, SUBCLASS 2.
Descriptor:Transferrin receptor protein 1, Serotransferrin, Reticulocyte binding protein 2, ...
Authors:Gruszczyk, J., Huang, R.K., Hong, C., Yu, Z., Tham, W.H.
Deposit date:2018-04-10
Release date:2018-06-20
Last modified:2018-07-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
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