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3J79
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, LARGE SUBUNIT
Descriptor:PROTEIN/RNA Complex
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-02
Release date:2014-07-16
Modification date:2015-06-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3J7A
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, SMALL SUBUNIT
Descriptor:PROTEIN/RNA Complex
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-03
Release date:2014-07-16
Modification date:2015-06-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3Q2B
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CRYSTAL STRUCTURE OF AN ACTIN DEPOLYMERIZING FACTOR
Descriptor:Cofilin/actin-depolymerizing factor homolog 1
Authors:Wong, W., Clarke, O.B., Gulbis, J.M., Baum, J.
Deposit date:2010-12-19
Release date:2011-06-01
Modification date:2011-06-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1
Proc.Natl.Acad.Sci.USA, 108, 2011
3TI7
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CRYSTAL STRUCTURE OF THE BASIC PROTEASE BPRV FROM THE OVINE FOOTROT PATHOGEN, DICHELOBACTER NODOSUS
Descriptor:Basic extracellular subtilisin-like protease BprV (E.C.3.4.21.-)
Authors:Wong, W., Whisstock, J.C., Porter, C.J.
Deposit date:2011-08-20
Release date:2011-10-19
Modification date:2012-01-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction.
J.Biol.Chem., 286, 2011
3TI9
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CRYSTAL STRUCTURE OF THE BASIC PROTEASE BPRB FROM THE OVINE FOOTROT PATHOGEN, DICHELOBACTER NODOSUS
Descriptor:Serine protease
Authors:Wong, W., Whisstock, J.C., Porter, C.J.
Deposit date:2011-08-20
Release date:2011-10-19
Modification date:2012-01-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction.
J.Biol.Chem., 286, 2011
5UMD
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STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTIMALARIAL DRUG MEFLOQUINE
Descriptor:60S ribosomal protein L2, 60S ribosomal protein L3, 60S ribosomal protein L4, 60S ribosomal protein L11a, putative, 60S ribosomal protein L6, putative, 60S ribosomal protein L6-2, putative, 60S ribosomal protein L7-3, putative, 60S ribosomal protein L13, putative, 60S ribosomal protein L13, 60S ribosomal protein L23, putative, 60S ribosomal protein L14, putative, 60S ribosomal protein L27a, putative, Ribosomal protein L15, 60S ribosomal protein L10, putative, 60S ribosomal protein L5, putative, 60S ribosomal protein L18-2, putative, 60S ribosomal protein L19, 60S ribosomal protein L18a, 60S ribosomal protein L21, 60S ribosomal protein L17, putative, 60S ribosomal protein L22, putative, 60S ribosomal protein L23, 60S ribosomal protein L26, putative, 60S ribosomal protein L24, putative, 60S ribosomal protein L27, 60S ribosomal protein L28, 60S ribosomal protein L35, putative, 60S ribosomal protein L29, putative, 60S ribosomal protein L7, putative, 60S ribosomal protein L30e, putative, 60S ribosomal protein L31, 60S ribosomal protein L32, 60S ribosomal protein L35Ae, putative, 60S ribosomal protein L34, 60S ribosomal protein L36, Ribosomal protein L37, 60S ribosomal protein L38, 60S ribosomal protein L39, Ubiquitin-60S ribosomal protein L40, 60S ribosomal protein L41, 60S ribosomal protein L37a, 60S ribosomal protein L44/RNA Complex
Authors:Wong, W., Bai, X.-C., Brown, A., Scheres, S., Baum, J.
Deposit date:2017-01-27
Release date:2017-03-01
Modification date:2017-03-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Nat Microbiol, 2, 2017
3LPA
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CRYSTAL STRUCTURE OF A SUBTILISIN-LIKE PROTEASE
Descriptor:Acidic extracellular subtilisin-like protease AprV2 (E.C.3.4.21.-)
Authors:Porter, C.J., Wong, W., Whisstock, J.C., Rood, J.I., Kennan, R.M.
Deposit date:2010-02-05
Release date:2010-12-08
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Plos Pathog., 6, 2010
3LPC
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CRYSTAL STRUCTURE OF A SUBTILISIN-LIKE PROTEASE
Descriptor:AprB2 (E.C.3.4.21.-)
Authors:Porter, C.J., Wong, W., Whisstock, J.C., Rood, J.I., Kennan, R.M.
Deposit date:2010-02-05
Release date:2010-12-08
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Plos Pathog., 6, 2010
3LPD
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CRYSTAL STRUCTURE OF A SUBTILISIN-LIKE PROTEASE
Descriptor:Acidic extracellular subtilisin-like protease AprV2 (E.C.3.4.21.-)
Authors:Porter, C.J., Wong, W., Whisstock, J.C., Rood, J.I., Kennan, R.M.
Deposit date:2010-02-05
Release date:2010-12-08
Modification date:2010-12-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Plos Pathog., 6, 2010
2QP2
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STRUCTURE OF A MACPF/PERFORIN-LIKE PROTEIN
Descriptor:Unknown protein
Authors:Rosado, C.J., Buckle, A.M., Law, R.H.P., Butcher, R.E., Kan, W.T., Bird, C.H., Ung, K., Browne, K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike, R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J., Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., Whisstock, J.C.
Deposit date:2007-07-22
Release date:2007-09-04
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A common fold mediates vertebrate defense and bacterial attack
Science, 317, 2007
4N92
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CRYSTAL STRUCTURE OF BETA-LACTAMSE PENP_E166S
Descriptor:Beta-lactamase (E.C.3.5.2.6)
Authors:Pan, X., Wong, W., Zhao, Y.
Deposit date:2013-10-19
Release date:2014-09-10
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
4N9K
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CRYSTAL STRUCTURE OF BETA-LACTAMSE PENP_E166S IN COMPLEX WITH CEPHALORIDINE
Descriptor:Beta-lactamase (E.C.3.5.2.6)
Authors:Pan, X., Wong, W., Zhao, Y.
Deposit date:2013-10-21
Release date:2014-09-10
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
4N9L
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CRYSTAL STRUCTURE OF BETA-LACTAMSE PENP_E166S IN COMPLEX WITH MEROPENEM
Descriptor:Beta-lactamase (E.C.3.5.2.6)
Authors:Pan, X., Wong, W., Zhao, Y.
Deposit date:2013-10-21
Release date:2014-09-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
5TIH
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STRUCTURAL BASIS FOR INHIBITION OF ERYTHROCYTE INVASION BY ANTIBODIES TO PLASMODIUM FALCIPARUM PROTEIN CYRPA
Descriptor:Cysteine-rich protective antigen, CyRPA antibody Fab Heavy Chain, CyRPA antibody Fab Light Chain
Authors:Chen, L., Xu, Y., Wang, W., Thompson, J.K., Goddard-Borger, E., Lawrence, M.C., Cowman, A.F.
Deposit date:2016-10-03
Release date:2017-03-01
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA.
Elife, 6, 2017
5TIK
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STRUCTURAL BASIS FOR INHIBITION OF ERYTHROCYTE INVASION BY ANTIBODIES TO PLASMODIUM FALCIPARUM PROTEIN CYRPA
Descriptor:Cysteine-rich protective antigen
Authors:Chen, L., Xu, Y., Wang, W., Thompson, J.K., Goddard-Borger, E., Lawrence, M.C., Cowman, A.F.
Deposit date:2016-10-03
Release date:2017-03-01
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA.
Elife, 6, 2017
3VPP
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CRYSTAL STRUCTURE OF THE HUMAN CLEC9A C-TYPE LECTIN-LIKE DOMAIN
Descriptor:C-type lectin domain family 9 member A
Authors:Czabotar, P.E., Zhang, J.G., Policheni, A.N., Shortman, K., Lahoud, M.H., Colman, P.M.
Deposit date:2012-03-07
Release date:2012-04-25
Modification date:2014-04-16
Method:X-RAY DIFFRACTION (1.642 Å)
Cite:The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity, 36, 2012
3JBN
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTION OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO P-TRNA
Descriptor:PROTEIN/RNA Complex
Authors:Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Modification date:2015-12-16
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
3JBO
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTION OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO P/E-TRNA
Descriptor:PROTEIN/RNA Complex
Authors:Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Modification date:2016-06-08
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
3JBP
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTION OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO E-TRNA
Descriptor:PROTEIN/RNA Complex
Authors:Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Modification date:2015-12-16
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
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