4Y2I | | GOLD ION BOUND TO GOLB | | Descriptor: | Putative metal-binding transport protein, GOLD ION | | Authors: | Wei, W., Wang, F., Ma, L., Zhao, J. | | Deposit date: | 2015-02-10 | | Release date: | 2016-02-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
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4Y2K | | REDUCED FORM OF APO-GOLB | | Descriptor: | Putative metal-binding transport protein | | Authors: | Wei, W., Wang, F., Ma, L., Zhao, J. | | Deposit date: | 2015-02-10 | | Release date: | 2016-02-10 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
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4Y2M | | APO-GOLB PROTEIN | | Descriptor: | Putative metal-binding transport protein, GOLD ION | | Authors: | Wei, W., Zhao, J., Wang, F. | | Deposit date: | 2015-02-10 | | Release date: | 2016-02-10 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
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5F0U | |
5F0W | |
5O51 | | AFROM2 CNH DOMAIN | | Descriptor: | Rho guanyl nucleotide exchange factor (Rom2), putative | | Authors: | Wei, W., van Aalten, D. | | Deposit date: | 2017-05-31 | | Release date: | 2018-06-13 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Rom2 CNH domain from Aspergillus fumigatus is an atypical seven-bladed WD-40 protein
To Be Published
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5I96 | | CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ISOCITRATE DEHYDROGENASE (IDH2) R140Q MUTANT HOMODIMER IN COMPLEX WITH AG-221 (ENASIDENIB) INHIBITOR. | | Descriptor: | Isocitrate dehydrogenase [NADP], mitochondrial, CALCIUM ION, ... | | Authors: | Wei, W., Zhang, B., Jin, L., Jiang, F., DeLaBarre, B., Travins, J.A., Padyana, A.K. | | Deposit date: | 2016-02-19 | | Release date: | 2017-03-08 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Cancer Discov, 7, 2017
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4JA8 | | COMPLEX OF MITOCHONDRIAL ISOCITRATE DEHYDROGENASE R140Q MUTANT WITH AGI-6780 INHIBITOR | | Descriptor: | Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Wei, W., Chen, L., Wu, M., Jiang, F., Travins, J., Qian, K., DeLaBarre, B. | | Deposit date: | 2013-02-18 | | Release date: | 2013-04-10 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
Science, 340, 2013
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4MZ7 | | STRUCTURAL INSIGHT INTO DGTP-DEPENDENT ACTIVATION OF TETRAMERIC SAMHD1 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE | | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Zhu, C., Gao, W., Zhao, K., Qin, X., Zhang, Y., Peng, X., Zhang, L., Dong, Y., Zhang, W., Li, P., Wei, W., Gong, Y., Yu, X.F. | | Deposit date: | 2013-09-29 | | Release date: | 2013-11-20 | | Last modified: | 2017-03-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
Nat Commun, 4, 2013
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3GLR | | CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ACETYL-LYSINE ACECS2 PEPTIDE | | Descriptor: | NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ... | | Authors: | Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B. | | Deposit date: | 2009-03-12 | | Release date: | 2009-06-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
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3GLS | | CRYSTAL STRUCTURE OF HUMAN SIRT3 | | Descriptor: | NAD-dependent deacetylase sirtuin-3, mitochondrial, ZINC ION, ... | | Authors: | Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B. | | Deposit date: | 2009-03-12 | | Release date: | 2009-06-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
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3GLT | | CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ADPR BOUND TO THE ACECS2 PEPTIDE CONTAINING A THIOACETYL LYSINE | | Descriptor: | NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ... | | Authors: | Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B. | | Deposit date: | 2009-03-12 | | Release date: | 2009-06-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
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3GLU | | CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ACECS2 PEPTIDE | | Descriptor: | NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ... | | Authors: | Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B. | | Deposit date: | 2009-03-12 | | Release date: | 2009-06-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
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3UO9 | | CRYSTAL STRUCTURE OF HUMAN GAC IN COMPLEX WITH GLUTAMATE AND BPTES | | Descriptor: | Glutaminase kidney isoform, mitochondrial, GLYCEROL, ... | | Authors: | DeLaBarre, B., Gross, S., Cheng, F., Gao, Y., Jha, A., Jiang, F., Song, J.J., Wei, W., Hurov, J.B. | | Deposit date: | 2011-11-16 | | Release date: | 2011-12-07 | | Last modified: | 2013-01-02 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Full-length human glutaminase in complex with an allosteric inhibitor.
Biochemistry, 50, 2011
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4RXO | | THE STRUCTURE OF GTP-BOUND SAMHD1 | | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION, PHOSPHATE ION, ... | | Authors: | Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F. | | Deposit date: | 2014-12-11 | | Release date: | 2015-03-11 | | Last modified: | 2015-03-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
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4RXP | | THE STRUCTURE OF GTP-DATP-BOUND SAMHD1 | | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F. | | Deposit date: | 2014-12-11 | | Release date: | 2015-03-11 | | Last modified: | 2015-03-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
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4RXQ | | THE STRUCTURE OF GTP-DUTP-BOUND SAMHD1 | | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, DEOXYURIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F. | | Deposit date: | 2014-12-11 | | Release date: | 2015-03-11 | | Last modified: | 2015-03-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
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4RXR | | THE STRUCTURE OF GTP-DCTP-BOUND SAMHD1 | | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F. | | Deposit date: | 2014-12-11 | | Release date: | 2015-03-11 | | Last modified: | 2015-03-25 | | Method: | X-RAY DIFFRACTION (2.117 Å) | | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
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4RXS | | THE STRUCTURE OF GTP-DTTP-BOUND SAMHD1 | | Descriptor: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F. | | Deposit date: | 2014-12-11 | | Release date: | 2015-03-11 | | Last modified: | 2015-03-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
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5XS9 | |
5I95 | | CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ISOCITRATE DEHYDROGENASE R140Q MUTANT HOMODIMER BOUND TO NADPH AND ALPHA-KETOGLUTARIC ACID | | Descriptor: | Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Zhang, B., Jin, L., Wu, W., Jiang, F., DeLaBarre, B., Travins, J.A., Padyana, A.K. | | Deposit date: | 2016-02-19 | | Release date: | 2017-03-01 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Cancer Discov, 7, 2017
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3S69 | | CRYSTAL STRUCTURE OF SAXTHROMBIN | | Descriptor: | Thrombin-like enzyme defibrase, CALCIUM ION | | Authors: | Huang, K., Zhao, W., Teng, M., Niu, L. | | Deposit date: | 2011-05-25 | | Release date: | 2012-05-23 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Structure of saxthrombin, a thrombin-like enzyme from Gloydius saxatilis.
Acta Crystallogr.,Sect.F, 67, 2011
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4X0R | | CRYSTAL STRUCTURE OF HUMAN MXB STALK DOMAIN | | Descriptor: | Interferon-induced GTP-binding protein Mx2 | | Authors: | Yu, X.-F., Xie, W. | | Deposit date: | 2014-11-23 | | Release date: | 2014-12-10 | | Last modified: | 2015-01-21 | | Method: | X-RAY DIFFRACTION (2.905 Å) | | Cite: | Structural insight into the assembly of human anti-HIV dynamin-like protein MxB/Mx2.
Biochem.Biophys.Res.Commun., 456, 2015
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3UNW | | CRYSTAL STRUCTURE OF HUMAN GAC IN COMPLEX WITH GLUTAMATE | | Descriptor: | Glutaminase kidney isoform, mitochondrial, GLUTAMIC ACID | | Authors: | DeLaBarre, B., Gross, S., Cheng, F., Gao, Y., Jha, A., Jiang, F., Song, J.J., Wie, W., Hurov, J. | | Deposit date: | 2011-11-16 | | Release date: | 2011-12-07 | | Last modified: | 2013-01-02 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Full-length human glutaminase in complex with an allosteric inhibitor.
Biochemistry, 50, 2011
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4G1N | | PKM2 IN COMPLEX WITH AN ACTIVATOR | | Descriptor: | Pyruvate kinase isozymes M1/M2, OXALATE ION, MAGNESIUM ION, ... | | Authors: | Kung, C., Hixon, J., Dang, L., DeLaBarre, B., Qian, K.C. | | Deposit date: | 2012-07-10 | | Release date: | 2012-10-10 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy.
Chem.Biol., 19, 2012
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