Author results

4Y2I
  • Download 4y2i
  • View 4y2i
Molmil generated image of 4y2i
GOLD ION BOUND TO GOLB
Descriptor:Putative metal-binding transport protein, GOLD ION
Authors:Wei, W., Wang, F., Ma, L., Zhao, J.
Deposit date:2015-02-10
Release date:2016-02-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
4Y2K
  • Download 4y2k
  • View 4y2k
Molmil generated image of 4y2k
REDUCED FORM OF APO-GOLB
Descriptor:Putative metal-binding transport protein
Authors:Wei, W., Wang, F., Ma, L., Zhao, J.
Deposit date:2015-02-10
Release date:2016-02-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
4Y2M
  • Download 4y2m
  • View 4y2m
Molmil generated image of 4y2m
APO-GOLB PROTEIN
Descriptor:Putative metal-binding transport protein, GOLD ION
Authors:Wei, W., Zhao, J., Wang, F.
Deposit date:2015-02-10
Release date:2016-02-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
5F0U
  • Download 5f0u
  • View 5f0u
Molmil generated image of 5f0u
CRYSTAL STRUCTURE OF GOLD BINDING PROTEIN
Descriptor:Putative copper chaperone, SILVER ION
Authors:Wei, W., Wang, F., Zhao, J.
Deposit date:2015-11-28
Release date:2017-01-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structure of tetrasilver bound to GolB at 1.70 Angstroms resolution
To Be Published
5F0W
  • Download 5f0w
  • View 5f0w
Molmil generated image of 5f0w
CRYSTAL STRUCTURE OF HUMAN COPPER HOMEOSTATIC PROTEINS ATOX1
Descriptor:Copper transport protein ATOX1, SILVER ION
Authors:Wei, W., Wang, F., Zhao, J.
Deposit date:2015-11-28
Release date:2017-01-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of tetrasilver bound to human copper homeostatic proteins atox1 at 1.7 Angstroms resolution
To Be Published
5O51
  • Download 5o51
  • View 5o51
Molmil generated image of 5o51
AFROM2 CNH DOMAIN
Descriptor:Rho guanyl nucleotide exchange factor (Rom2), putative
Authors:Wei, W., van Aalten, D.
Deposit date:2017-05-31
Release date:2018-06-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Rom2 CNH domain from Aspergillus fumigatus is an atypical seven-bladed WD-40 protein
To Be Published
5I96
  • Download 5i96
  • View 5i96
Molmil generated image of 5i96
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ISOCITRATE DEHYDROGENASE (IDH2) R140Q MUTANT HOMODIMER IN COMPLEX WITH AG-221 (ENASIDENIB) INHIBITOR.
Descriptor:Isocitrate dehydrogenase [NADP], mitochondrial, CALCIUM ION, ...
Authors:Wei, W., Zhang, B., Jin, L., Jiang, F., DeLaBarre, B., Travins, J.A., Padyana, A.K.
Deposit date:2016-02-19
Release date:2017-03-08
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Cancer Discov, 7, 2017
4JA8
  • Download 4ja8
  • View 4ja8
Molmil generated image of 4ja8
COMPLEX OF MITOCHONDRIAL ISOCITRATE DEHYDROGENASE R140Q MUTANT WITH AGI-6780 INHIBITOR
Descriptor:Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Wei, W., Chen, L., Wu, M., Jiang, F., Travins, J., Qian, K., DeLaBarre, B.
Deposit date:2013-02-18
Release date:2013-04-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
Science, 340, 2013
4MZ7
  • Download 4mz7
  • View 4mz7
Molmil generated image of 4mz7
STRUCTURAL INSIGHT INTO DGTP-DEPENDENT ACTIVATION OF TETRAMERIC SAMHD1 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Zhu, C., Gao, W., Zhao, K., Qin, X., Zhang, Y., Peng, X., Zhang, L., Dong, Y., Zhang, W., Li, P., Wei, W., Gong, Y., Yu, X.F.
Deposit date:2013-09-29
Release date:2013-11-20
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
Nat Commun, 4, 2013
3GLR
  • Download 3glr
  • View 3glr
Molmil generated image of 3glr
CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ACETYL-LYSINE ACECS2 PEPTIDE
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3GLS
  • Download 3gls
  • View 3gls
Molmil generated image of 3gls
CRYSTAL STRUCTURE OF HUMAN SIRT3
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, ZINC ION, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3GLT
  • Download 3glt
  • View 3glt
Molmil generated image of 3glt
CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ADPR BOUND TO THE ACECS2 PEPTIDE CONTAINING A THIOACETYL LYSINE
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3GLU
  • Download 3glu
  • View 3glu
Molmil generated image of 3glu
CRYSTAL STRUCTURE OF HUMAN SIRT3 WITH ACECS2 PEPTIDE
Descriptor:NAD-dependent deacetylase sirtuin-3, mitochondrial, Acetyl-coenzyme A synthetase 2-like, ...
Authors:Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Bemis, J.E., Jirousek, M.R., Milne, J.C., Westphal, C.H., Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3UO9
  • Download 3uo9
  • View 3uo9
Molmil generated image of 3uo9
CRYSTAL STRUCTURE OF HUMAN GAC IN COMPLEX WITH GLUTAMATE AND BPTES
Descriptor:Glutaminase kidney isoform, mitochondrial, GLYCEROL, ...
Authors:DeLaBarre, B., Gross, S., Cheng, F., Gao, Y., Jha, A., Jiang, F., Song, J.J., Wei, W., Hurov, J.B.
Deposit date:2011-11-16
Release date:2011-12-07
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Full-length human glutaminase in complex with an allosteric inhibitor.
Biochemistry, 50, 2011
4RXO
  • Download 4rxo
  • View 4rxo
Molmil generated image of 4rxo
THE STRUCTURE OF GTP-BOUND SAMHD1
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ZINC ION, PHOSPHATE ION, ...
Authors:Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
4RXP
  • Download 4rxp
  • View 4rxp
Molmil generated image of 4rxp
THE STRUCTURE OF GTP-DATP-BOUND SAMHD1
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
4RXQ
  • Download 4rxq
  • View 4rxq
Molmil generated image of 4rxq
THE STRUCTURE OF GTP-DUTP-BOUND SAMHD1
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, DEOXYURIDINE-5'-TRIPHOSPHATE, ...
Authors:Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
4RXR
  • Download 4rxr
  • View 4rxr
Molmil generated image of 4rxr
THE STRUCTURE OF GTP-DCTP-BOUND SAMHD1
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.117 Å)
Cite:The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
4RXS
  • Download 4rxs
  • View 4rxs
Molmil generated image of 4rxs
THE STRUCTURE OF GTP-DTTP-BOUND SAMHD1
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Zhu, C.F., Wei, W., Peng, X., Dong, Y.H., Gong, Y., Yu, X.F.
Deposit date:2014-12-11
Release date:2015-03-11
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
Acta Crystallogr.,Sect.D, 71, 2015
5XS9
  • Download 5xs9
  • View 5xs9
Molmil generated image of 5xs9
CRYSTAL STRUCTURE OF MYCOBACTERIUM SMEGMATIS BIOQ
Descriptor:TetR family transcriptional regulator
Authors:Zhang, Y., Ji, Q., Feng, Y.
Deposit date:2017-06-13
Release date:2018-06-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of BioQ suggests a distinct regulatory mechanism for biotin, a nutritional virulence factor in Mycobacterium
To Be Published
5I95
  • Download 5i95
  • View 5i95
Molmil generated image of 5i95
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ISOCITRATE DEHYDROGENASE R140Q MUTANT HOMODIMER BOUND TO NADPH AND ALPHA-KETOGLUTARIC ACID
Descriptor:Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Zhang, B., Jin, L., Wu, W., Jiang, F., DeLaBarre, B., Travins, J.A., Padyana, A.K.
Deposit date:2016-02-19
Release date:2017-03-01
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Cancer Discov, 7, 2017
3S69
  • Download 3s69
  • View 3s69
Molmil generated image of 3s69
CRYSTAL STRUCTURE OF SAXTHROMBIN
Descriptor:Thrombin-like enzyme defibrase, CALCIUM ION
Authors:Huang, K., Zhao, W., Teng, M., Niu, L.
Deposit date:2011-05-25
Release date:2012-05-23
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structure of saxthrombin, a thrombin-like enzyme from Gloydius saxatilis.
Acta Crystallogr.,Sect.F, 67, 2011
4X0R
  • Download 4x0r
  • View 4x0r
Molmil generated image of 4x0r
CRYSTAL STRUCTURE OF HUMAN MXB STALK DOMAIN
Descriptor:Interferon-induced GTP-binding protein Mx2
Authors:Yu, X.-F., Xie, W.
Deposit date:2014-11-23
Release date:2014-12-10
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.905 Å)
Cite:Structural insight into the assembly of human anti-HIV dynamin-like protein MxB/Mx2.
Biochem.Biophys.Res.Commun., 456, 2015
3UNW
  • Download 3unw
  • View 3unw
Molmil generated image of 3unw
CRYSTAL STRUCTURE OF HUMAN GAC IN COMPLEX WITH GLUTAMATE
Descriptor:Glutaminase kidney isoform, mitochondrial, GLUTAMIC ACID
Authors:DeLaBarre, B., Gross, S., Cheng, F., Gao, Y., Jha, A., Jiang, F., Song, J.J., Wie, W., Hurov, J.
Deposit date:2011-11-16
Release date:2011-12-07
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Full-length human glutaminase in complex with an allosteric inhibitor.
Biochemistry, 50, 2011
4G1N
  • Download 4g1n
  • View 4g1n
Molmil generated image of 4g1n
PKM2 IN COMPLEX WITH AN ACTIVATOR
Descriptor:Pyruvate kinase isozymes M1/M2, OXALATE ION, MAGNESIUM ION, ...
Authors:Kung, C., Hixon, J., Dang, L., DeLaBarre, B., Qian, K.C.
Deposit date:2012-07-10
Release date:2012-10-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy.
Chem.Biol., 19, 2012
<12>