5I96

Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (IDH2) R140Q Mutant Homodimer in Complex with AG-221 (Enasidenib) Inhibitor.

Summary for 5I96

• Entry DOI: 10.2210/pdb5i96/pdb
• Related: 5I95
• Descriptor: Isocitrate dehydrogenase [NADP], mitochondrial, CALCIUM ION, GLYCEROL, ... (8 entities in total)
• Functional Keywords: idh, idh2, enasidenib, ag-221, idh2 ag-221, icd-m, idp nadp(+)-specific icdh oxalosuccinate decarboxylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion: P48735
• Total number of polymer chains: 2
• Total formula weight: 106234.93

Authors

Wei, W.,Zhang, B.,Jin, L.,Jiang, F.,DeLaBarre, B.,Travins, J.A.,Padyana, A.K. (deposition date: 2016-02-19, release date: 2017-03-08, Last modification date: 2023-09-27)

• Primary citation: Yen, K.,Travins, J.,Wang, F.,David, M.D.,Artin, E.,Straley, K.,Padyana, A.,Gross, S.,DeLaBarre, B.,Tobin, E.,Chen, Y.,Nagaraja, R.,Choe, S.,Jin, L.,Konteatis, Z.,Cianchetta, G.,Saunders, J.O.,Salituro, F.G.,Quivoron, C.,Opolon, P.,Bawa, O.,Saada, V.,Paci, A.,Broutin, S.,Bernard, O.A.,de Botton, S.,Marteyn, B.S.,Pilichowska, M.,Xu, Y.,Fang, C.,Jiang, F.,Wei, W.,Jin, S.,Silverman, L.,Liu, W.,Yang, H.,Dang, L.,Dorsch, M.,Penard-Lacronique, V.,Biller, S.A.,Su, S.M.; AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.; Cancer Discov, 7:478-493, 2017; PubMed: 28193778; DOI: 10.1158/2159-8290.CD-16-1034

Experimental method

X-RAY DIFFRACTION (1.55 Å)