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4JA8

Complex of Mitochondrial Isocitrate Dehydrogenase R140Q Mutant with AGI-6780 Inhibitor

Summary for 4JA8
Entry DOI10.2210/pdb4ja8/pdb
DescriptorIsocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-[5-(cyclopropylsulfamoyl)-2-thiophen-3-yl-phenyl]-3-[3-(trifluoromethyl)phenyl]urea, ... (6 entities in total)
Functional Keywordsprotein-inhibitor complex, metabolic enzyme oncometabolite, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion: P48735
Total number of polymer chains2
Total formula weight96688.35
Authors
Wei, W.,Chen, L.,Wu, M.,Jiang, F.,Travins, J.,Qian, K.,DeLaBarre, B. (deposition date: 2013-02-18, release date: 2013-04-10, Last modification date: 2024-02-28)
Primary citationWang, F.,Travins, J.,DeLaBarre, B.,Penard-Lacronique, V.,Schalm, S.,Hansen, E.,Straley, K.,Kernytsky, A.,Liu, W.,Gliser, C.,Yang, H.,Gross, S.,Artin, E.,Saada, V.,Mylonas, E.,Quivoron, C.,Popovici-Muller, J.,Saunders, J.O.,Salituro, F.G.,Yan, S.,Murray, S.,Wei, W.,Gao, Y.,Dang, L.,Dorsch, M.,Agresta, S.,Schenkein, D.P.,Biller, S.A.,Su, S.M.,de Botton, S.,Yen, K.E.
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
Science, 340:622-626, 2013
Cited by
PubMed: 23558173
DOI: 10.1126/science.1234769
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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