Author results

3N3Y
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE X (THYX) FROM HELICOBACTER PYLORI WITH FAD AND DUMP AT 2.31A RESOLUTION
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Wang, K., Wang, Q., Chen, J., Chen, L., Jiang, H., Shen, X.
Deposit date:2010-05-21
Release date:2011-05-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.307 Å)
Cite:Structure, Enzymatic Characterization and Inhibitor Discovery of Thymidylate Synthase X (ThyX) from Helicobacter pylori Strain SS1
To be Published
4HK1
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CRYSTAL STRUCTURE OF PCNA FROM DROSOPHILA MELANOGASTER
Descriptor:Proliferating cell nuclear antigen
Authors:Wang, K., Shi, Z.B., Zhou, Z.C.
Deposit date:2012-10-14
Release date:2013-04-10
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structure of PCNA from Drosophila melanogaster.
Acta Crystallogr.,Sect.F, 69, 2013
6DAD
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1.65 ANGSTROM CRYSTAL STRUCTURE OF THE N97I CA/CAM:CAV1.2 IQ DOMAIN COMPLEX
Descriptor:Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C, CALCIUM ION
Authors:Wang, K., Van Petegem, F.
Deposit date:2018-05-01
Release date:2018-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DAE
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2.0 ANGSTROM CRYSTAL STRUCTURE OF THE D95V CA/CAM:CAV1.2 IQ DOMAIN COMPLEX
Descriptor:Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C, CALCIUM ION
Authors:Wang, K., Lu, J., Van Petegem, F.
Deposit date:2018-05-01
Release date:2018-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DAF
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2.4 ANGSTROM CRYSTAL STRUCTURE OF THE F141L CA/CAM:CAV1.2 IQ DOMAIN COMPLEX
Descriptor:Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C, CALCIUM ION
Authors:Wang, K., Van Petegem, F.
Deposit date:2018-05-01
Release date:2018-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DAH
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2.5 ANGSTROM CRYSTAL STRUCTURE OF THE N97S CAM MUTANT
Descriptor:Calmodulin-1, CALCIUM ION
Authors:Wang, K., Van Petegem, F.
Deposit date:2018-05-01
Release date:2018-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3UTC
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EC_ISPH IN COMPLEX WITH (E)-4-HYDROXYBUT-3-ENYL DIPHOSPHATE
Descriptor:4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER, (3E)-4-hydroxybut-3-en-1-yl trihydrogen diphosphate
Authors:Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Li, K., Schulz, C., Oldfield, E., Groll, M.
Deposit date:2011-11-25
Release date:2012-09-05
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of acetylene hydratase activity of the iron-sulphur protein IspH.
Nat Commun, 3, 2012
3URK
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ISPH IN COMPLEX WITH PROPYNYL DIPHOSPHATE (1061)
Descriptor:4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER, prop-2-yn-1-yl trihydrogen diphosphate
Authors:Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Schulz, C., Oldfield, E., Groll, M.
Deposit date:2011-11-22
Release date:2012-09-05
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of acetylene hydratase activity of the iron-sulphur protein IspH.
Nat Commun, 3, 2012
3UTD
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EC_ISPH IN COMPLEX WITH 4-OXOPENTYL DIPHOSPHATE
Descriptor:4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, 4-oxopentyl trihydrogen diphosphate
Authors:Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Schulz, C., Oldfield, E., Groll, M.
Deposit date:2011-11-25
Release date:2012-09-05
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of acetylene hydratase activity of the iron-sulphur protein IspH.
Nat Commun, 3, 2012
3UV3
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EC_ISPH IN COMPLEX WITH BUT-2-YNYL DIPHOSPHATE (1086)
Descriptor:4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER, but-2-yn-1-yl trihydrogen diphosphate
Authors:Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Schulz, C., Oldfield, E., Groll, M.
Deposit date:2011-11-29
Release date:2012-09-05
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of acetylene hydratase activity of the iron-sulphur protein IspH.
Nat Commun, 3, 2012
3UV6
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EC_ISPH IN COMPLEX WITH 4-HYDROXYBUTYL DIPHOSPHATE (1301)
Descriptor:4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER, 4-hydroxybutyl trihydrogen diphosphate
Authors:Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Schulz, C., Oldfield, E., Groll, M.
Deposit date:2011-11-29
Release date:2012-09-05
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of acetylene hydratase activity of the iron-sulphur protein IspH.
Nat Commun, 3, 2012
3UV7
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EC_ISPH IN COMPLEX WITH BUTA-2,3-DIENYL DIPHOSPHATE (1300)
Descriptor:4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER, buta-2,3-dien-1-yl trihydrogen diphosphate
Authors:Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Schulz, C., Oldfield, E., Groll, M.
Deposit date:2011-11-29
Release date:2012-09-05
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of acetylene hydratase activity of the iron-sulphur protein IspH.
Nat Commun, 3, 2012
3UWM
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EC_ISPH IN COMPLEX WITH 4-OXOBUTYL DIPHOSPHATE (1302)
Descriptor:4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER, 4-oxobutyl trihydrogen diphosphate, ...
Authors:Span, I., Wang, K., Wang, W., Zhang, Y., Bacher, A., Eisenreich, W., Schulz, C., Oldfield, E., Groll, M.
Deposit date:2011-12-02
Release date:2012-09-05
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of acetylene hydratase activity of the iron-sulphur protein IspH.
Nat Commun, 3, 2012
2NZ0
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CRYSTAL STRUCTURE OF POTASSIUM CHANNEL KV4.3 IN COMPLEX WITH ITS REGULATORY SUBUNIT KCHIP1 (CASP TARGET)
Descriptor:Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 3, CALCIUM ION, ...
Authors:Wang, H., Yan, Y., Shen, Y., Chen, L., Wang, K.
Deposit date:2006-11-22
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for modulation of Kv4 K(+) channels by auxiliary KChIP subunits.
Nat.Neurosci., 10, 2007
3DD4
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STRUCTURAL BASIS OF KCHIP4A MODULATION OF KV4.3 SLOW INACTIVATION
Descriptor:Kv channel-interacting protein 4, CALCIUM ION
Authors:Chai, J., Wang, H., Wang, K.
Deposit date:2008-06-05
Release date:2008-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation.
J.Biol.Chem., 284, 2009
3FXJ
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH PHOSPHATE AT 3 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
3FXK
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH PHOSPHATE AT 10 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
3FXL
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH CITRATE AT 1 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
3FXM
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH CITRATE AT 10 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
3FXO
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH PHOSPHATE AT 1 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
3NFC
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CRYSTAL STRUCTURE OF E.COLI MAZF TOXIN
Descriptor:PemK-like protein 1
Authors:Wang, X., Wang, K., Su, X., Zhang, J.
Deposit date:2010-06-10
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biochemical and Structural Analysis of E. coli MazF Toxin
To be Published
4EB3
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CRYSTAL STRUCTURE OF ISPH IN COMPLEX WITH ISO-HMBPP
Descriptor:4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IRON/SULFUR CLUSTER, 3-(hydroxymethyl)but-3-en-1-yl trihydrogen diphosphate
Authors:Wang, W., Wang, K., Span, I., Bacher, A., Groll, M., Oldfield, E.
Deposit date:2012-03-23
Release date:2013-02-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.
J.Am.Chem.Soc., 134, 2012
5XHX
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CRYSTAL STRUCTURE OF VQSR LBD DOMAIN FROM PSEUDOMONAS AERUGINOSA
Descriptor:Helix-turn-helix transcriptional regulator
Authors:Gu, L., He, Q., Wang, K., Wang, F.
Deposit date:2017-04-24
Release date:2017-05-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of VqsR LBD domain from Pseudomonas aeruginosa
To Be Published
3NPR
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CRYSTAL STRUCTURE OF THE C(30) CAROTENOID DEHYDROSQUALENE SYNTHASE FROM S. AUREUS COMPLEXED WITH PRESQUALENE DIPHOSPHATE (PSPP)
Descriptor:Dehydrosqualene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate, MAGNESIUM ION
Authors:Lin, F.-Y., Liu, C.-I., Liu, Y.-L., Wang, K., Zhang, Y., Oldfield, E.
Deposit date:2010-06-28
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3NRI
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CRYSTAL STRUCTURE OF THE C(30) CAROTENOID DEHYDROSQUALENE SYNTHASE FROM S. AUREUS COMPLEXED WITH DEHYDROSQUALENE (DHS)
Descriptor:Dehydrosqualene synthase, (6E,10R,13S,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,11,13,14,18,22-octaene
Authors:Lin, F.-Y., Liu, C.-I., Liu, Y.-L., Wang, K., Zhang, Y., Oldfield, E.
Deposit date:2010-06-30
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010