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3OIK
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HUMAN CARBONIC ANHYDRASE II MUTANT A65S, N67Q (CA IX MIMIC) BOUND BY 2-ETHYLESTRADIOL 3,17-O,O-BIS-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL DISULFAMATE, ...
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-19
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
3OIL
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HUMAN CARBONIC ANHYDRASE II MUTANT A65S, N67Q (CA IX MIMIC) BOUND BY 2-ETHYLESTRADIOL 3-O-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (14beta,17alpha)-2-ethyl-17-hydroxyestra-1(10),2,4-trien-3-yl sulfamate
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-19
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
3OIM
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HUMAN CARBONIC ANHYDRASE II BOUND BY 2-ETHYLESTRADIOL 3-O-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (14beta,17alpha)-2-ethyl-17-hydroxyestra-1(10),2,4-trien-3-yl sulfamate, ...
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-19
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
3OKU
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 2-ETHYLESTRONE-3-O-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (9beta)-2-ethyl-17-oxoestra-1(10),2,4-trien-3-yl sulfamate, ...
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-25
Release date:2011-07-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
3OKV
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HUMAN CARBONIC ANHYDRASE II A65S, N67Q (CA IX MIMIC) BOUND WITH 2-ETHYLESTRONE 3-O-SULFAMATE
Descriptor:Carbonic anhydrase 2, ZINC ION, (9beta)-2-ethyl-17-oxoestra-1(10),2,4-trien-3-yl sulfamate, ...
Authors:Sippel, K.H., Stander, B.A., Robbins, A.H., Tu, C.K., Agbandje-McKenna, M., Silverman, D.N., Joubert, A.M., McKenna, R.
Deposit date:2010-08-25
Release date:2011-07-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8, 2011
1T9N
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, SULFATE ION
Authors:Fisher, Z., Hernandez Prada, J., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-18
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TE3
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, CHLORIDE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-24
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TEQ
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, HYDROXIDE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-25
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TEU
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-25
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TG3
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, SULFATE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-28
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TG9
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-28
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1TH9
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION, SULFATE ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-06-01
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1THK
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-06-01
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
1XV8
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CRYSTAL STRUCTURE OF HUMAN SALIVARY ALPHA-AMYLASE DIMER
Descriptor:Alpha-amylase, CALCIUM ION, CHLORIDE ION
Authors:Fisher, S.Z., Govindasamy, L., Tu, C.K., Silverman, D.N., Rajaniemi, H., McKenna, R.
Deposit date:2004-10-27
Release date:2005-10-11
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Human Salivary Alpha-Amylase Dimer
To be Published
1MOO
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SITE SPECIFIC MUTANT (H64A) OF HUMAN CARBONIC ANHYDRASE II AT HIGH RESOLUTION
Descriptor:Carbonic Anhydrase II, ZINC ION, MERCURY (II) ION, ...
Authors:Duda, D.M., Govindasamy, L., Agbandje-McKenna, M., Tu, C.K., Silverman, D.N., McKenna, R.
Deposit date:2002-09-09
Release date:2002-09-18
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer.
Acta Crystallogr.,Sect.D, 59, 2003
1LZV
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SITE-SPECIFIC MUTANT (TYR7 REPLACED WITH HIS) OF HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic Anhydrase II, ZINC ION
Authors:Tu, C.K., Qian, M., An, H., Wadhwa, N.R., Duda, D.M., Yoshioka, C., Pathak, Y., McKenna, R., Laipis, P.J., Silverman, D.N.
Deposit date:2002-06-11
Release date:2002-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase.
J.Biol.Chem., 277, 2002
1TBT
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EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase II, ZINC ION
Authors:Fisher, Z., Hernandez Prada, J.A., Tu, C.K., Duda, D., Yoshioka, C., An, H., Govindasamy, L., Silverman, D.N., McKenna, R.
Deposit date:2004-05-20
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II.
Biochemistry, 44, 2005
2HFW
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STRUCTURAL AND KINETIC ANALYSIS OF PROTON SHUTTLE RESIDUES IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE III
Descriptor:Carbonic anhydrase 3, ZINC ION
Authors:Elder, I., Fisher, S.Z., Laipis, P.J., Tu, C.K., McKenna, R., Silverman, D.N.
Deposit date:2006-06-26
Release date:2007-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.
Proteins, 68, 2007
2NWO
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STRUCTURAL AND KINETIC EFFECT OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWP
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWY
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS ON THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NWZ
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS ON THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-16
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NXR
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STRUCTURAL EFFECTS OF HYDROPHOBIC MUTATIONS ON THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NXS
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
2NXT
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STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II
Descriptor:carbonic anhydrase 2, ZINC ION
Authors:Fisher, S.Z., McKenna, R.
Deposit date:2006-11-19
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II.
Biochemistry, 46, 2007
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