3OIK

Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate

Summary for 3OIK

• Entry DOI: 10.2210/pdb3oik/pdb
• Related: 3OIL 3OIM 3OKU 3OKV
• Descriptor: Carbonic anhydrase 2, ZINC ION, (9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL DISULFAMATE, ... (5 entities in total)
• Functional Keywords: 2-ethylestrone, estradiol, sulfamate, mixed alpha-beta, carbon dioxide/bicarbonate conversion, lyase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P00918
• Total number of polymer chains: 1
• Total formula weight: 29935.18

Authors

Sippel, K.H.,Stander, B.A.,Robbins, A.H.,Tu, C.K.,Agbandje-McKenna, M.,Silverman, D.N.,Joubert, A.M.,McKenna, R. (deposition date: 2010-08-19, release date: 2011-07-06, Last modification date: 2023-09-06)

• Primary citation: Sippel, K.H.,Stander, B.A.,Robbins, A.H.,Tu, C.K.,Agbandje-McKenna, M.,Silverman, D.N.,Joubert, A.M.,McKenna, R.; Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds; LETT.DRUG DES.DISCOVERY, 8:-, 2011

Experimental method

X-RAY DIFFRACTION (1.5 Å)