Author results

2NTX
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PRONE8
Descriptor:Emb|CAB41934.1
Authors:Thomas, C., Fricke, I., Scrima, A., Berken, A., Wittinghofer, A.
Deposit date:2006-11-08
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Evidence for a Common Intermediate in Small G Protein-GEF Reactions
Mol.Cell, 25, 2007
2NTY
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ROP4-GDP-PRONE8
Descriptor:Emb|CAB41934.1, Rac-like GTP-binding protein ARAC5, GUANOSINE-5'-DIPHOSPHATE
Authors:Thomas, C., Fricke, I., Scrima, A., Berken, A., Wittinghofer, A.
Deposit date:2006-11-08
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Evidence for a Common Intermediate in Small G Protein-GEF Reactions
Mol.Cell, 25, 2007
2WBL
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THREE-DIMENSIONAL STRUCTURE OF A BINARY ROP-PRONE COMPLEX
Descriptor:RHO OF PLANTS GUANINE NUCLEOTIDE EXCHANGE FACTOR 8, RAC-LIKE GTP-BINDING PROTEIN ARAC2
Authors:Thomas, C., Fricke, I., Weyand, M., Berken, A.
Deposit date:2009-03-02
Release date:2009-04-14
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:3D Structure of a Binary Rop-Prone Complex: The Final Intermediate for a Complete Set of Molecular Snapshots of the Ropgef Reaction.
Biol.Chem., 390, 2009
3BWD
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CRYSTAL STRUCTURE OF THE PLANT RHO PROTEIN ROP5
Descriptor:Rac-like GTP-binding protein ARAC6, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Thomas, C., Berken, A.
Deposit date:2008-01-09
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Crystal structure of the plant Rho protein ROP5
To be Published
3S8W
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D2 DOMAIN OF HUMAN IFNAR2
Descriptor:Interferon alpha/beta receptor 2, CHLORIDE ION
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-05-31
Release date:2011-08-31
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
3S98
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HUMAN IFNAR1
Descriptor:Interferon alpha/beta receptor 1, N-ACETYL-D-GLUCOSAMINE
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-06-01
Release date:2011-08-31
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
3S9D
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BINARY COMPLEX BETWEEN IFNA2 AND IFNAR2
Descriptor:Interferon alpha-2, Interferon alpha/beta receptor 2, CHLORIDE ION
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-06-01
Release date:2011-08-31
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.9999 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
3SE3
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HUMAN IFNA2-IFNAR TERNARY COMPLEX
Descriptor:Interferon alpha/beta receptor 1, Interferon alpha 2b, Interferon alpha/beta receptor 2, ...
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-06-10
Release date:2011-08-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (4.0001 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
3SE4
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HUMAN IFNW-IFNAR TERNARY COMPLEX
Descriptor:Interferon alpha/beta receptor 1, Interferon omega-1, Interferon alpha/beta receptor 2, ...
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-06-10
Release date:2011-08-31
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3.5001 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
4DEP
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STRUCTURE OF THE IL-1B SIGNALING COMPLEX
Descriptor:Interleukin-1 beta, Interleukin-1 receptor type 1, Interleukin-1 receptor accessory protein, ...
Authors:Thomas, C., Garcia, K.C.
Deposit date:2012-01-21
Release date:2012-03-21
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the activating IL-1 receptor signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
5OPI
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CRYSTAL STRUCTURE OF THE TAPBPR-MHC I PEPTIDE EDITING COMPLEX
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Thomas, C., Tampe, R.
Deposit date:2017-08-09
Release date:2017-10-18
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the TAPBPR-MHC I complex defines the mechanism of peptide loading and editing.
Science, 358, 2017
3GQY
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, L(+)-TARTARIC ACID, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-03-24
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
3GR4
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, L(+)-TARTARIC ACID, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-03-24
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
3H6O
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, UNKNOWN ATOM OR ION, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-04-23
Release date:2009-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
3BRW
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STRUCTURE OF THE RAP-RAPGAP COMPLEX
Descriptor:Rap1 GTPase-activating protein 1, Ras-related protein Rap-1b, MAGNESIUM ION, ...
Authors:Scrima, A., Thomas, C., Deaconescu, D., Wittinghofer, A.
Deposit date:2007-12-21
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues
Embo J., 27, 2008
4F0A
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CRYSTAL STRUCTURE OF XWNT8 IN COMPLEX WITH THE CYSTEINE-RICH DOMAIN OF FRIZZLED 8
Descriptor:Frizzled-8, Protein Wnt-8, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Janda, C.Y., Waghray, D., Levin, A.M., Thomas, C., Garcia, K.C.
Deposit date:2012-05-03
Release date:2012-06-13
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural basis of Wnt recognition by Frizzled.
Science, 337, 2012
4GAF
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CRYSTAL STRUCTURE OF EBI-005, A CHIMERA OF HUMAN IL-1BETA AND IL-1RA, BOUND TO HUMAN INTERLEUKIN-1 RECEPTOR TYPE 1
Descriptor:EBI-005, Interleukin-1 receptor type 1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hou, J., Townson, S.A., Kovalchin, J.T., Masci, A., Kiner, O., Shu, Y., King, B., Thomas, C., Garcia, K.C., Furfine, E.S., Barnes, T.M.
Deposit date:2012-07-25
Release date:2013-02-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Design of a superior cytokine antagonist for topical ophthalmic use.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GAI
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CRYSTAL STRUCTURE OF EBI-005, A CHIMERA OF HUMAN IL-1BETA AND IL-1RA
Descriptor:EBI-005
Authors:Hou, J., Townson, S.A., Kovalchin, J.T., Masci, A., Kiner, O., Shu, Y., King, B., Thomas, C., Garcia, K.C., Furfine, E.S., Barnes, T.M.
Deposit date:2012-07-25
Release date:2013-02-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Design of a superior cytokine antagonist for topical ophthalmic use.
Proc.Natl.Acad.Sci.USA, 110, 2013
5E4E
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ENGINEERED INTERLEUKIN-13 BOUND TO RECEPTOR
Descriptor:Interleukin-13, Interleukin-4 receptor subunit alpha, Interleukin-13 receptor subunit alpha-1, ...
Authors:Moraga, I., Thomas, C., Jude, K.M., Garcia, K.C.
Deposit date:2015-10-05
Release date:2015-12-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.
Sci.Signal., 8, 2015
5IM4
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CRYSTAL STRUCTURE OF DESIGNED TWO-COMPONENT SELF-ASSEMBLING ICOSAHEDRAL CAGE I52-32
Descriptor:6,7-dimethyl-8-ribityllumazine synthase, Phosphotransferase system, mannose/fructose-specific component IIA
Authors:Liu, Y.A., Cascio, D., Sawaya, M.R., Bale, J.B., Collazo, M.J., Thomas, C., Sheffler, W., King, N.P., Baker, D., Yeates, T.O.
Deposit date:2016-03-05
Release date:2016-07-27
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Accurate design of megadalton-scale two-component icosahedral protein complexes.
Science, 353, 2016
5IM5
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CRYSTAL STRUCTURE OF DESIGNED TWO-COMPONENT SELF-ASSEMBLING ICOSAHEDRAL CAGE I53-40
Descriptor:Designed Riboflavin synthase, Designed Keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase
Authors:Liu, Y.A., Cascio, D., Sawaya, M.R., Bale, J.B., Collazo, M.J., Thomas, C., Sheffler, W., King, N.P., Baker, D., Yeates, T.O.
Deposit date:2016-03-05
Release date:2016-07-27
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (3.699 Å)
Cite:Accurate design of megadalton-scale two-component icosahedral protein complexes.
Science, 353, 2016
5IM6
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CRYSTAL STRUCTURE OF DESIGNED TWO-COMPONENT SELF-ASSEMBLING ICOSAHEDRAL CAGE I32-28
Descriptor:Designed self-assembling icosahedral cage I32-28 trimeric subunit, Designed self-assembling icosahedral cage I32-28 dimeric subunit
Authors:Liu, Y.A., Cascio, D., Sawaya, M.R., Bale, J.B., Collazo, M.J., Thomas, C., Sheffler, W., King, N.P., Baker, D., Yeates, T.O.
Deposit date:2016-03-05
Release date:2016-07-27
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (5.588 Å)
Cite:Accurate design of megadalton-scale two-component icosahedral protein complexes.
Science, 353, 2016
5MKK
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CRYSTAL STRUCTURE OF THE HETERODIMERIC ABC TRANSPORTER TMRAB, A HOMOLOG OF THE ANTIGEN TRANSLOCATION COMPLEX TAP
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, SULFATE ION
Authors:Noell, A., Thomas, C., Tomasiak, T.M., Olieric, V., Wang, M., Diederichs, K., Stroud, R.M., Pos, K.M., Tampe, R.
Deposit date:2016-12-05
Release date:2017-01-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3ME3
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline, BETA-FRUCTOSE-1,6-DIPHOSPHATE, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-04-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
3U2Z
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, UNKNOWN ATOM OR ION, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-10-04
Release date:2012-09-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat.Chem.Biol., 8, 2012
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