Author results

2NTX
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PRONE8
Descriptor:Emb|CAB41934.1
Authors:Thomas, C., Fricke, I., Scrima, A., Berken, A., Wittinghofer, A.
Deposit date:2006-11-08
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Evidence for a Common Intermediate in Small G Protein-GEF Reactions
Mol.Cell, 25, 2007
2NTY
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ROP4-GDP-PRONE8
Descriptor:Emb|CAB41934.1, Rac-like GTP-binding protein ARAC5, GUANOSINE-5'-DIPHOSPHATE
Authors:Thomas, C., Fricke, I., Scrima, A., Berken, A., Wittinghofer, A.
Deposit date:2006-11-08
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Evidence for a Common Intermediate in Small G Protein-GEF Reactions
Mol.Cell, 25, 2007
2WBL
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THREE-DIMENSIONAL STRUCTURE OF A BINARY ROP-PRONE COMPLEX
Descriptor:RHO OF PLANTS GUANINE NUCLEOTIDE EXCHANGE FACTOR 8, RAC-LIKE GTP-BINDING PROTEIN ARAC2
Authors:Thomas, C., Fricke, I., Weyand, M., Berken, A.
Deposit date:2009-03-02
Release date:2009-04-14
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:3D Structure of a Binary Rop-Prone Complex: The Final Intermediate for a Complete Set of Molecular Snapshots of the Ropgef Reaction.
Biol.Chem., 390, 2009
3BWD
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CRYSTAL STRUCTURE OF THE PLANT RHO PROTEIN ROP5
Descriptor:Rac-like GTP-binding protein ARAC6, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Thomas, C., Berken, A.
Deposit date:2008-01-09
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Crystal structure of the plant Rho protein ROP5
To be Published
3S8W
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D2 DOMAIN OF HUMAN IFNAR2
Descriptor:Interferon alpha/beta receptor 2, CHLORIDE ION
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-05-31
Release date:2011-08-31
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
3S98
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HUMAN IFNAR1
Descriptor:Interferon alpha/beta receptor 1, N-ACETYL-D-GLUCOSAMINE
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-06-01
Release date:2011-08-31
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
3S9D
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BINARY COMPLEX BETWEEN IFNA2 AND IFNAR2
Descriptor:Interferon alpha-2, Interferon alpha/beta receptor 2, CHLORIDE ION
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-06-01
Release date:2011-08-31
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.9999 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
3SE3
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HUMAN IFNA2-IFNAR TERNARY COMPLEX
Descriptor:Interferon alpha/beta receptor 1, Interferon alpha 2b, Interferon alpha/beta receptor 2, ...
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-06-10
Release date:2011-08-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (4.0001 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
3SE4
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HUMAN IFNW-IFNAR TERNARY COMPLEX
Descriptor:Interferon alpha/beta receptor 1, Interferon omega-1, Interferon alpha/beta receptor 2, ...
Authors:Thomas, C., Garcia, K.C.
Deposit date:2011-06-10
Release date:2011-08-31
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3.5001 Å)
Cite:Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
4DEP
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STRUCTURE OF THE IL-1B SIGNALING COMPLEX
Descriptor:Interleukin-1 beta, Interleukin-1 receptor type 1, Interleukin-1 receptor accessory protein, ...
Authors:Thomas, C., Garcia, K.C.
Deposit date:2012-01-21
Release date:2012-03-21
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the activating IL-1 receptor signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
5OPI
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CRYSTAL STRUCTURE OF THE TAPBPR-MHC I PEPTIDE EDITING COMPLEX
Descriptor:H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, ...
Authors:Thomas, C., Tampe, R.
Deposit date:2017-08-09
Release date:2017-10-18
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the TAPBPR-MHC I complex defines the mechanism of peptide loading and editing.
Science, 358, 2017
6RAF
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HETERODIMERIC ABC EXPORTER TMRAB IN INWARD-FACING NARROW CONFORMATION UNDER TURNOVER CONDITIONS
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, Anti-vesicular stomatitis virus N VHH, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6RAG
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HETERODIMERIC ABC EXPORTER TMRAB IN INWARD-FACING WIDE CONFORMATION UNDER TURNOVER CONDITIONS
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10, MAGNESIUM ION, ...
Authors:Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6RAH
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HETERODIMERIC ABC EXPORTER TMRAB IN ATP-BOUND OUTWARD-FACING OPEN CONFORMATION
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6RAI
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HETERODIMERIC ABC EXPORTER TMRAB IN ATP-BOUND OUTWARD-FACING OCCLUDED CONFORMATION
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6RAJ
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HETERODIMERIC ABC EXPORTER TMRAB IN VANADATE TRAPPED OUTWARD-FACING OPEN CONFORMATION
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10, ADP ORTHOVANADATE, ...
Authors:Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6RAK
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HETERODIMERIC ABC EXPORTER TMRAB IN VANADATE TRAPPED OUTWARD-FACING OCCLUDED CONFORMATION
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10, ADP ORTHOVANADATE, ...
Authors:Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6RAL
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HETERODIMERIC ABC EXPORTER TMRAB UNDER TURNOVER CONDITIONS IN ASYMMETRIC UNLOCKED RETURN CONFORMATION
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6RAM
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HETERODIMERIC ABC EXPORTER TMRAB UNDER TURNOVER CONDITIONS IN ASYMMETRIC UNLOCKED RETURN CONFORMATION WITH WIDER OPENED INTRACELLULAR GATE
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
6RAN
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HETERODIMERIC ABC EXPORTER TMRAB IN INWARD-FACING WIDE CONFORMATION
Descriptor:Multidrug resistance ABC transporter ATP-binding and permease protein, Nanobody Nb9F10
Authors:Thomas, C., Januliene, D., Mehdipour, A.R., Hofmann, S., Hummer, G., Moeller, A., Tampe, R.
Deposit date:2019-04-06
Release date:2019-07-31
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature, 571, 2019
3GQY
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, L(+)-TARTARIC ACID, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-03-24
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
3GR4
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, L(+)-TARTARIC ACID, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-03-24
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
3H6O
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ACTIVATOR-BOUND STRUCTURE OF HUMAN PYRUVATE KINASE M2
Descriptor:Pyruvate kinase isozymes M1/M2, BETA-FRUCTOSE-1,6-DIPHOSPHATE, UNKNOWN ATOM OR ION, ...
Authors:Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-04-23
Release date:2009-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activator-Bound Structures of Human Pyruvate Kinase M2
to be published
3BRW
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STRUCTURE OF THE RAP-RAPGAP COMPLEX
Descriptor:Rap1 GTPase-activating protein 1, Ras-related protein Rap-1b, MAGNESIUM ION, ...
Authors:Scrima, A., Thomas, C., Deaconescu, D., Wittinghofer, A.
Deposit date:2007-12-21
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues
Embo J., 27, 2008
4F0A
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CRYSTAL STRUCTURE OF XWNT8 IN COMPLEX WITH THE CYSTEINE-RICH DOMAIN OF FRIZZLED 8
Descriptor:Frizzled-8, Protein Wnt-8, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Janda, C.Y., Waghray, D., Levin, A.M., Thomas, C., Garcia, K.C.
Deposit date:2012-05-03
Release date:2012-06-13
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural basis of Wnt recognition by Frizzled.
Science, 337, 2012
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