Author results

1TTT
  • Download 1ttt
  • View 1ttt
Molmil generated image of 1ttt
PHE-TRNA, ELONGATION FACTOR EF-TU:GDPNP TERNARY COMPLEX
Descriptor:TRANSFER RIBONUCLEIC ACID (YEAST, PHE), OF ELONGATION FACTOR TU (EF-TU), ...
Authors:Nissen, P., Kjeldgaard, M., Thirup, S., Polekhina, G., Reshetnikova, L., Clark, B.F.C., Nyborg, J.
Deposit date:1995-11-16
Release date:1996-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog.
Science, 270, 1995
1TUI
  • Download 1tui
  • View 1tui
Molmil generated image of 1tui
INTACT ELONGATION FACTOR TU IN COMPLEX WITH GDP
Descriptor:ELONGATION FACTOR TU, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Polekhina, G., Thirup, S., Kjeldgaard, M., Nissen, P., Lippmann, C., Nyborg, J.
Deposit date:1996-05-23
Release date:1997-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Helix unwinding in the effector region of elongation factor EF-Tu-GDP.
Structure, 4, 1996
1B23
  • Download 1b23
  • View 1b23
Molmil generated image of 1b23
E. COLI CYSTEINYL-TRNA AND T. AQUATICUS ELONGATION FACTOR EF-TU:GTP TERNARY COMPLEX
Descriptor:CYSTEINYL TRNA, ELONGATION FACTOR TU, MAGNESIUM ION, ...
Authors:Nissen, P., Kjeldgaard, M., Thirup, S., Nyborg, J.
Deposit date:1998-12-04
Release date:1998-12-07
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of Cys-tRNACys-EF-Tu-GDPNP reveals general and specific features in the ternary complex and in tRNA.
Structure Fold.Des., 7, 1999
1D2E
  • Download 1d2e
  • View 1d2e
Molmil generated image of 1d2e
CRYSTAL STRUCTURE OF MITOCHONDRIAL EF-TU IN COMPLEX WITH GDP
Descriptor:ELONGATION FACTOR TU (EF-TU), MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Andersen, G.R., Thirup, S., Spremulli, L.L., Nyborg, J.
Deposit date:1999-09-23
Release date:1999-09-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:High resolution crystal structure of bovine mitochondrial EF-Tu in complex with GDP.
J.Mol.Biol., 297, 2000
4A1I
  • Download 4a1i
  • View 4a1i
Molmil generated image of 4a1i
YKUD FROM B.SUBTILIS
Descriptor:PUTATIVE L, D-TRANSPEPTIDASE YKUD, SULFATE ION, ...
Authors:Blaise, M., Fuglsang Midtgaard, S., Roi Midtgaard, S., Boesen, T., Thirup, S.
Deposit date:2011-09-15
Release date:2012-09-26
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structures of Three New Crystal Forms of the Ykud L,D-Transpeptidase from B. Subtilis.
To be Published
4A1J
  • Download 4a1j
  • View 4a1j
Molmil generated image of 4a1j
YKUD L,D-TRANSPEPTIDASE FROM B.SUBTILIS
Descriptor:PUTATIVE L, D-TRANSPEPTIDASE YKUD, SULFATE ION
Authors:Blaise, M., Fuglsang Midtgaard, S., Roi Midtgaard, S., Boesen, T., Thirup, S.
Deposit date:2011-09-15
Release date:2012-09-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Ykud
To be Published
4A1K
  • Download 4a1k
  • View 4a1k
Molmil generated image of 4a1k
YKUD L,D-TRANSPEPTIDASE
Descriptor:PUTATIVE L, D-TRANSPEPTIDASE YKUD, SULFATE ION
Authors:Blaise, M., Fuglsang Midtgaard, S., Roi Midtgaard, S., Boesen, T., Thirup, S.
Deposit date:2011-09-15
Release date:2012-09-26
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of Three New Crystal Forms of the Ykud L,D-Transpeptidase from B. Subtilis.
To be Published
4N7E
  • Download 4n7e
  • View 4n7e
Molmil generated image of 4n7e
CRYSTAL STRUCTURE OF THE VPS10P DOMAIN OF HUMAN SORTILIN/NTS3 IN COMPLEX WITH AF38469
Descriptor:Sortilin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Andersen, J.L., Strandbygaard, D., Thirup, S.
Deposit date:2013-10-15
Release date:2014-01-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.
Bioorg.Med.Chem.Lett., 24, 2014
4MSL
  • Download 4msl
  • View 4msl
Molmil generated image of 4msl
CRYSTAL STRUCTURE OF THE VPS10P DOMAIN OF HUMAN SORTILIN/NTS3 IN COMPLEX WITH AF40431
Descriptor:Sortilin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Andersen, J.L., Strandbygaard, D., Thirup, S.
Deposit date:2013-09-18
Release date:2014-02-12
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.
Acta Crystallogr.,Sect.D, 70, 2014
4XCM
  • Download 4xcm
  • View 4xcm
Molmil generated image of 4xcm
CRYSTAL STRUCTURE OF THE PUTATIVE NLPC/P60 D,L ENDOPEPTIDASE FROM T. THERMOPHILUS
Descriptor:Cell wall-binding endopeptidase-related protein
Authors:Wong, J., Midtgaard, S., Gysel, K., Thygesen, M.B., Sorensen, K.K., Jensen, K.J., Stougaard, J., Thirup, S., Blaise, M.
Deposit date:2014-12-18
Release date:2015-01-14
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase.
Acta Crystallogr.,Sect.D, 71, 2015
5MRH
  • Download 5mrh
  • View 5mrh
Molmil generated image of 5mrh
CRYSTAL STRUCTURE OF THE VPS10P DOMAIN OF HUMAN SORTILIN/NTS3 IN COMPLEX WITH TRIAZOLONE 1
Descriptor:Sortilin, N-ACETYL-D-GLUCOSAMINE, 3-(3-methylbutyl)-4~{H}-1,2,3-triazol-5-one, ...
Authors:Andersen, J.L., Strandbygaard, D., Thirup, S.
Deposit date:2016-12-23
Release date:2017-05-17
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin.
Bioorg. Med. Chem. Lett., 27, 2017
5MRI
  • Download 5mri
  • View 5mri
Molmil generated image of 5mri
CRYSTAL STRUCTURE OF THE VPS10P DOMAIN OF HUMAN SORTILIN/NTS3 IN COMPLEX WITH TRIAZOLONE 18
Descriptor:Sortilin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Andersen, J.L., Strandbygaard, D., Thirup, S.
Deposit date:2016-12-23
Release date:2017-05-17
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin.
Bioorg. Med. Chem. Lett., 27, 2017
1AYO
  • Download 1ayo
  • View 1ayo
Molmil generated image of 1ayo
RECEPTOR BINDING DOMAIN OF BOVINE ALPHA-2-MACROGLOBULIN
Descriptor:ALPHA-2-MACROGLOBULIN, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION
Authors:Jenner, L.B., Husted, L., Thirup, S., Sottrup-Jensen, L., Nyborg, J.
Deposit date:1997-11-07
Release date:1998-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the receptor-binding domain of alpha 2-macroglobulin.
Structure, 6, 1998
1EFT
  • Download 1eft
  • View 1eft
Molmil generated image of 1eft
THE CRYSTAL STRUCTURE OF ELONGATION FACTOR EF-TU FROM THERMUS AQUATICUS IN THE GTP CONFORMATION
Descriptor:ELONGATION FACTOR TU, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Kjeldgaard, M., Nissen, P., Thirup, S., Nyborg, J.
Deposit date:1993-08-24
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation.
Structure, 1, 1993
1ETU
  • Download 1etu
  • View 1etu
Molmil generated image of 1etu
STRUCTURAL DETAILS OF THE BINDING OF GUANOSINE DIPHOSPHATE TO ELONGATION FACTOR TU FROM E. COLI AS STUDIED BY X-RAY CRYSTALLOGRAPHY
Descriptor:ELONGATION FACTOR TU, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Clark, B.F.C., Lacour, T.F.M., Kjeldgaard, M., Morikawa, K., Nyborg, J., Rubin, R., Thirup, S.
Deposit date:1988-01-15
Release date:1988-07-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.
EMBO J., 4, 1985
3KFU
  • Download 3kfu
  • View 3kfu
Molmil generated image of 3kfu
CRYSTAL STRUCTURE OF THE TRANSAMIDOSOME
Descriptor:Non-discriminating and archaeal-type aspartyl-tRNA synthetase, Glutamyl-tRNA(Gln) amidotransferase subunit A, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, ...
Authors:Blaise, M., Bailly, M., Frechin, M., Thirup, S., Becker, H.D., Kern, D.
Deposit date:2009-10-28
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a transfer-ribonucleoprotein particle that promotes asparagine formation.
Embo J., 29, 2010
4ACJ
  • Download 4acj
  • View 4acj
Molmil generated image of 4acj
CRYSTAL STRUCTURE OF THE TLDC DOMAIN OF OXIDATION RESISTANCE PROTEIN 2 FROM ZEBRAFISH
Descriptor:WU\:FB25H12 PROTEIN,
Authors:Blaise, M., B Alsarraf, H.M.A., Wong, J.E.M.M., Midtgaard, S.R., Laroche, F., Schack, L., Spaink, H., Stougaard, J., Thirup, S.
Deposit date:2011-12-15
Release date:2012-02-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Crystal Structure of the Tldc Domain of Oxidation Resistance Protein 2 from Zebrafish.
Proteins, 80, 2012
5OCA
  • Download 5oca
  • View 5oca
Molmil generated image of 5oca
PCSK9:FAB COMPLEX WITH DEXTRAN SULFATE
Descriptor:Proprotein convertase subtilisin/kexin type 9, Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, ...
Authors:Thirup, S.S., Vilstrup, J.P.
Deposit date:2017-06-30
Release date:2017-09-20
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Nat Commun, 8, 2017
3F6K
  • Download 3f6k
  • View 3f6k
Molmil generated image of 3f6k
CRYSTAL STRUCTURE OF THE VPS10P DOMAIN OF HUMAN SORTILIN/NTS3 IN COMPLEX WITH NEUROTENSIN
Descriptor:Sortilin, Neurotensin, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Quistgaard, E.M., Madsen, P., Groftehauge, M.K., Nissen, P., Petersen, C.M., Thirup, S.
Deposit date:2008-11-06
Release date:2008-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain.
Nat.Struct.Mol.Biol., 16, 2009
1EFC
  • Download 1efc
  • View 1efc
Molmil generated image of 1efc
INTACT ELONGATION FACTOR FROM E.COLI
Descriptor:PROTEIN (ELONGATION FACTOR), MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Song, H., Parsons, M.R., Rowsell, S., Leonard, G., Phillips, S.E.V.
Deposit date:1998-11-24
Release date:1999-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of intact elongation factor EF-Tu from Escherichia coli in GDP conformation at 2.05 A resolution.
J.Mol.Biol., 285, 1999
1LS2
  • Download 1ls2
  • View 1ls2
Molmil generated image of 1ls2
FITTING OF EF-TU AND TRNA IN THE LOW RESOLUTION CRYO-EM MAP OF AN EF-TU TERNARY COMPLEX (GDP AND KIRROMYCIN) BOUND TO E. COLI 70S RIBOSOME
Descriptor:Phenylalanine transfer RNA, Elongation Factor Tu
Authors:Valle, M., Sengupta, J., Swami, N.K., Grassucci, R.A., Burkhardt, N., Nierhaus, K.H., Agrawal, R.K., Frank, J.
Deposit date:2002-05-16
Release date:2002-06-26
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (16.799999 Å)
Cite:Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process.
EMBO J., 21, 2002
1LU3
  • Download 1lu3
  • View 1lu3
Molmil generated image of 1lu3
SEPARATE FITTING OF THE ANTICODON LOOP REGION OF TRNA (NUCLEOTIDE 26-42) IN THE LOW RESOLUTION CRYO-EM MAP OF AN EF-TU TERNARY COMPLEX (GDP AND KIRROMYCIN) BOUND TO E. COLI 70S RIBOSOME
Descriptor:PHENYLALANINE TRANSFER RNA
Authors:Valle, M., Sengupta, J., Swami, N.K., Grassucci, R.A., Burkhardt, N., Nierhaus, K.H., Agrawal, R.K., Frank, J.
Deposit date:2002-05-21
Release date:2002-06-26
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (16.799999 Å)
Cite:Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process.
EMBO J., 21, 2002
1OB2
  • Download 1ob2
  • View 1ob2
Molmil generated image of 1ob2
E. COLI ELONGATION FACTOR EF-TU COMPLEXED WITH THE ANTIBIOTIC KIRROMYCIN, A GTP ANALOG, AND PHE-TRNA
Descriptor:ELONGATION FACTOR TU, TRANSFER-RNA, PHE, ...
Authors:Kristensen, O., Nissen, P., Nyborg, J.
Deposit date:2003-01-24
Release date:2004-05-27
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Kirromycin Defines a Specific Domain Arrangement of Elongation Factor EF-TU
To be Published
4UZ2
  • Download 4uz2
  • View 4uz2
Molmil generated image of 4uz2
CRYSTAL STRUCTURE OF THE N-TERMINAL LYSM DOMAINS FROM THE PUTATIVE NLPC/P60 D,L ENDOPEPTIDASE FROM T. THERMOPHILUS
Descriptor:CELL WALL-BINDING ENDOPEPTIDASE-RELATED PROTEIN
Authors:Wong, J.E.M.M., Blaise, M.
Deposit date:2014-09-04
Release date:2015-01-14
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An Intermolecular Binding Mechanism Involving Multiple Lysm Domains Mediates Carbohydrate Recognition by an Endopeptidase.
Acta Crystallogr.,Sect.D, 71, 2015
4UZ3
  • Download 4uz3
  • View 4uz3
Molmil generated image of 4uz3
CRYSTAL STRUCTURE OF THE N-TERMINAL LYSM DOMAINS FROM THE PUTATIVE NLPC/P60 D,L ENDOPEPTIDASE FROM T. THERMOPHILUS BOUND TO N-ACETYL-CHITOHEXAOSE
Descriptor:CELL WALL-BINDING ENDOPEPTIDASE-RELATED PROTEIN, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Wong, J.E.M.M., Blaise, M.
Deposit date:2014-09-04
Release date:2015-01-14
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:An Intermolecular Binding Mechanism Involving Multiple Lysm Domains Mediates Carbohydrate Recognition by an Endopeptidase.
Acta Crystallogr.,Sect.D, 71, 2015
<12>