3F6K
Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin
Summary for 3F6K
| Entry DOI | 10.2210/pdb3f6k/pdb |
| Descriptor | Sortilin, Neurotensin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
| Functional Keywords | protein sorting receptor, 10-bladed beta-propeller, cys-rich domains, ssortilin, sortilin vps10p-d, protein-peptide complex, developmental protein, differentiation, endocytosis, endoplasmic reticulum, endosome, glycoprotein, golgi apparatus, lysosome, membrane, phosphoprotein, receptor, transmembrane, transport, cytoplasmic vesicle, secreted, signaling protein |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 2 |
| Total formula weight | 79703.86 |
| Authors | Quistgaard, E.M.,Madsen, P.,Groftehauge, M.K.,Nissen, P.,Petersen, C.M.,Thirup, S. (deposition date: 2008-11-06, release date: 2008-12-30, Last modification date: 2024-11-06) |
| Primary citation | Quistgaard, E.M.,Madsen, P.,Groftehauge, M.K.,Nissen, P.,Petersen, C.M.,Thirup, S.S. Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat.Struct.Mol.Biol., 16:96-98, 2009 Cited by PubMed Abstract: The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-A resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain. Binding competition studies suggest that additional binding sites, for example, for the prodomain of nerve growth factor-beta, are present in the tunnel and that competition for binding relates to the restricted space inside the propeller. PubMed: 19122660DOI: 10.1038/nsmb.1543 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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