3F6K
Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sortilin | polymer | 685 | 76774.7 | 1 | UniProt (Q99523) Pfam (PF15902) Pfam (PF15901) | Homo sapiens | Neurotensin receptor 3, NTR3, NTS3, Glycoprotein 95, Gp95, 100 kDa NT receptor |
| 2 | B (N) | Neurotensin | polymer | 13 | 1675.9 | 1 | UniProt (P30990) | ||
| 3 | C (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | E (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 6 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | G, H (A, N) | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence modifications
A: 45 - 723 (UniProt: Q99523)
| PDB | External Database | Details |
|---|---|---|
| Met 617 | Val 650 | variant |
| His 724 | - | expression tag |
| His 725 | - | expression tag |
| His 726 | - | expression tag |
| His 727 | - | expression tag |
| His 728 | - | expression tag |
| His 729 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78450.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1010.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 242.3 | |
| All* | Total formula weight | 79703.9 |
