4N7E

Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF38469

Summary for 4N7E

• Entry DOI: 10.2210/pdb4n7e/pdb
• Related: 3F6K 4MSL
• Descriptor: Sortilin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: sortilin, small molecule ligand, af38469, af40431, prongf, alzheimer's disease, beta-propeller asp-box repeat, vps10p domain, 10cc domain, receptor sorting, membrane, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 79276.25

Authors

Andersen, J.L.,Strandbygaard, D.,Thirup, S. (deposition date: 2013-10-15, release date: 2014-01-22, Last modification date: 2023-09-20)

• Primary citation: Schrder, T.J.,Christensen, S.,Lindberg, S.,Langgard, M.,David, L.,Maltas, P.J.,Eskildsen, J.,Jacobsen, J.,Tagmose, L.,Simonsen, K.B.,Biilmann Rnn, L.C.,de Jong, I.E.,Malik, I.J.,Karlsson, J.J.,Bundgaard, C.,Egebjerg, J.,Stavenhagen, J.B.,Strandbygard, D.,Thirup, S.,Andersen, J.L.,Uppalanchi, S.,Pervaram, S.,Kasturi, S.P.,Eradi, P.,Sakumudi, D.R.,Watson, S.P.; The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.; Bioorg.Med.Chem.Lett., 24:177-180, 2014; PubMed: 24355129; DOI: 10.1016/j.bmcl.2013.11.046

Experimental method

X-RAY DIFFRACTION (2.7 Å)