4MSL

Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with AF40431

Summary for 4MSL

• Entry DOI: 10.2210/pdb4msl/pdb
• Related: 3F6K
• Descriptor: Sortilin, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: prongf, alzheimer's disease, beta-propeller, asp-box repeat, vps10p domain, 10cc domain, receptor sorting, peptide binding, protein binding, membrane, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 79639.68

Authors

Andersen, J.L.,Strandbygaard, D.,Thirup, S. (deposition date: 2013-09-18, release date: 2014-02-12, Last modification date: 2020-07-29)

• Primary citation: Andersen, J.L.,Schrder, T.J.,Christensen, S.,Strandbygard, D.,Pallesen, L.T.,Garcia-Alai, M.M.,Lindberg, S.,Langgard, M.,Eskildsen, J.C.,David, L.,Tagmose, L.,Simonsen, K.B.,Maltas, P.J.,Rnn, L.C.,de Jong, I.E.,Malik, I.J.,Egebjerg, J.,Karlsson, J.J.,Uppalanchi, S.,Sakumudi, D.R.,Eradi, P.,Watson, S.P.,Thirup, S.; Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.; Acta Crystallogr.,Sect.D, 70:451-460, 2014; PubMed: 24531479; DOI: 10.1107/S1399004713030149

Experimental method

X-RAY DIFFRACTION (2.7 Å)