6F8S
| Toxin-Antitoxin complex GraTA | Descriptor: | DI(HYDROXYETHYL)ETHER, Putative Killer protein, SULFATE ION, ... | Authors: | Talavera, A, Loris, R. | Deposit date: | 2017-12-13 | Release date: | 2018-07-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT. Nat Commun, 10, 2019
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5MI8
| Structure of the phosphomimetic mutant of EF-Tu T383E | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, BETA-MERCAPTOETHANOL, ... | Authors: | Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A. | Deposit date: | 2016-11-27 | Release date: | 2017-12-20 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors. Sci Adv, 4, 2018
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6F8H
| antitoxin GraA | Descriptor: | XRE family transcriptional regulator | Authors: | Talavera, A, Loris, R. | Deposit date: | 2017-12-13 | Release date: | 2019-01-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT. Nat Commun, 10, 2019
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6FIX
| antitoxin GraA in complex with its operator | Descriptor: | DNA (30-MER), XRE family transcriptional regulator | Authors: | Talavera, A, Loris, R. | Deposit date: | 2018-01-19 | Release date: | 2019-01-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT. Nat Commun, 10, 2019
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2XKN
| Crystal structure of the Fab fragment of the anti-EGFR antibody 7A7 | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ANTI-EGFR ANTIBODY 7A7 | Authors: | Talavera, A, Mackenzie, J, Friemann, R, Krengel, U. | Deposit date: | 2010-07-09 | Release date: | 2011-06-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure of the Fab Fragment of the Anti-Murine Egfr Antibody 7A7 and Exploration of its Receptor Binding Site. Mol.Immunol., 48, 2011
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3GKW
| Crystal structure of the Fab fragment of Nimotuzumab. An anti-epidermal growth factor receptor antibody | Descriptor: | DI(HYDROXYETHYL)ETHER, Heavy chain of the antibody Nimotuzumab, Light chain of the antibody Nimotuzumab, ... | Authors: | Talavera, A, Friemann, R, Martinez-Fleites, C, Moreno, E, Krengel, U. | Deposit date: | 2009-03-11 | Release date: | 2009-08-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation Cancer Res., 69, 2009
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5MI3
| Structure of phosphorylated translation elongation factor EF-Tu from E. coli | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A. | Deposit date: | 2016-11-27 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors. Sci Adv, 4, 2018
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5MI9
| Structure of the phosphomimetic mutant of the elongation factor EF-Tu T62E | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A. | Deposit date: | 2016-11-27 | Release date: | 2017-12-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors. Sci Adv, 4, 2018
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3IU4
| anti NeuGcGM3 ganglioside chimeric antibody chP3 | Descriptor: | SULFATE ION, chP3 Fab heavy chain, chP3 Fab light chain | Authors: | Eriksson, A, Okvist, M, Talavera, A, Krengel, U. | Deposit date: | 2009-08-29 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody. Mol.Immunol., 46, 2009
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3M7Q
| Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Caribbean sea anemone stichodactyla helianthus in complex with bovine pancreatic trypsin | Descriptor: | Cationic trypsin, Kunitz-type proteinase inhibitor SHPI-1, PHOSPHATE ION | Authors: | Garcia-Fernandez, R, Redecke, L, Pons, T, Perbandt, M, Gil, D, Talavera, A, Gonzalez, Y, de los angeles Chavez, M, Betzel, C. | Deposit date: | 2010-03-17 | Release date: | 2011-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural insights into serine protease inhibition by a marine invertebrate BPTI Kunitz-type inhibitor. J.Struct.Biol., 180, 2012
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1RIH
| Crystal Structure of Fab 14F7, a unique anti-tumor antibody specific for N-glycolyl GM3 | Descriptor: | heavy chain of antibody 14F7, light chain of antibody 14F7 | Authors: | Krengel, U, Olsson, L.-L, Martinez, C, Talavera, A, Rojas, G, Mier, E, Angstrom, J, Moreno, E. | Deposit date: | 2003-11-17 | Release date: | 2004-01-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure and Molecular Interactions of a Unique Antitumor Antibody Specific for N-Glycolyl GM3. J.Biol.Chem., 279, 2004
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8AD6
| Structure of DarB bound to c-di-AMP | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CBS domain-containing protein | Authors: | Garcia-Pino, A, Talavera, A. | Deposit date: | 2022-07-07 | Release date: | 2023-07-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Structure of DarB bound to c-di-AMP To Be Published
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3DD9
| Structure of DocH66Y dimer | Descriptor: | Death on curing protein | Authors: | Garcia-Pino, A, Loris, R. | Deposit date: | 2008-06-05 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding J. Biol. Chem., 289, 2014
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2MF2
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7ZTB
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4MZP
| MazF from S. aureus crystal form III, C2221, 2.7 A | Descriptor: | MazF mRNA interferase | Authors: | Zorzini, V, Loris, R, van Nuland, N.A.J, Cheung, A. | Deposit date: | 2013-09-30 | Release date: | 2014-05-21 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics. Nucleic Acids Res., 42, 2014
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4MZT
| MazF from S. aureus crystal form II, C2221, 2.3 A | Descriptor: | MazF mRNA interferase | Authors: | Zorzini, V, Loris, R, van Nuland, N.A.J, Cheung, A. | Deposit date: | 2013-09-30 | Release date: | 2014-05-21 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.303 Å) | Cite: | Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics. Nucleic Acids Res., 42, 2014
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4MZM
| MazF from S. aureus crystal form I, P212121, 2.1 A | Descriptor: | mRNA interferase MazF | Authors: | Zorzini, V, Loris, R, van Nuland, N.A.J, Cheung, A. | Deposit date: | 2013-09-30 | Release date: | 2014-05-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics. Nucleic Acids Res., 42, 2014
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4ZLX
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4ZM0
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4ZM2
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6S2U
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6S2T
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6S2V
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3OFW
| Crystal structure of recombinant Kunitz Type serine protease Inhibitor-1 from the Carribean sea anemone stichodactyla helianthus | Descriptor: | CHLORIDE ION, Kunitz-type proteinase inhibitor SHPI-1 | Authors: | Garcia-Fernandez, R, Redecke, L, Pons, T, Perbandt, M, Talavera, A, Gil, D, Gonzalez, Y, de los Angeles Chavez, M, Betzel, C. | Deposit date: | 2010-08-16 | Release date: | 2011-08-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus. Acta Crystallogr.,Sect.F, 68, 2012
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