Author results

1EGA
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CRYSTAL STRUCTURE OF A WIDELY CONSERVED GTPASE ERA
Descriptor:PROTEIN (GTP-BINDING PROTEIN ERA), SULFATE ION
Authors:Chen, X., Ji, X.
Deposit date:1998-12-01
Release date:1999-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif.
Proc.Natl.Acad.Sci.USA, 96, 1999
1R0E
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GLYCOGEN SYNTHASE KINASE-3 BETA IN COMPLEX WITH 3-INDOLYL-4-ARYLMALEIMIDE INHIBITOR
Descriptor:Glycogen synthase kinase-3 beta, CITRATE ANION, 3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE
Authors:Allard, J., Nikolcheva, T., Gong, L., Wang, J., Dunten, P., Avnur, Z., Waters, R., Sun, Q., Skinner, B.
Deposit date:2003-09-20
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:From genetics to therapeutics: the Wnt pathway and osteoporosis
To be Published
2NMP
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CRYSTAL STRUCTURE OF HUMAN CYSTATHIONINE GAMMA LYASE
Descriptor:Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE
Authors:Karlberg, T., Uppenberg, J., Arrowsmith, C., Berglund, H., Busam, R.D., Collins, R., Edwards, A., Ericsson, U.B., Flodin, S., Flores, A., Graslund, S., Hallberg, B.M., Hammarstrom, M., Hogbom, M., Johansson, I., Kotenyova, T., Magnusdottir, A., Moche, M., Nilsson, M.E., Nordlund, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., van-den-Berg, S., Wallden, K., Weigelt, J., Holmberg-Schiavone, L., Structural Genomics Consortium (SGC)
Deposit date:2006-10-23
Release date:2006-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S
J.Biol.Chem., 284, 2009
3BUM
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN SPROUTY2
Descriptor:Portein sprouty homolog 2, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, A.R., Buschdorf, P.J., Sun, Q., Guy, R.G., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUN
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN SPROUTY4
Descriptor:13-meric peptide from Portein sprouty homolog 4, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUO
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN EGF RECEPTOR'
Descriptor:13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUW
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN SYK
Descriptor:13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUX
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN C-MET
Descriptor:13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3COG
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CRYSTAL STRUCTURE OF HUMAN CYSTATHIONASE (CYSTATHIONINE GAMMA LYASE) IN COMPLEX WITH DL-PROPARGYLGLYCINE
Descriptor:Cystathionine gamma-lyase, NITRATE ION, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Collins, R., Karlberg, T., Lehtio, L., Arrowsmith, C.H., Berglund, H., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kallas, A., Kotenyova, T., Moche, M., Nilsson, M.E., Nordlund, P., Nyman, T., Olesen, K., Persson, C., Schuler, H., Svensson, L., Thorsell, A.G., Tresaugues, L., Van den Berg, S., Sagermark, J., Busam, R.D., Welin, M., Weigelt, J., Wikstrom, M., Structural Genomics Consortium (SGC)
Deposit date:2008-03-28
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.
J.Biol.Chem., 284, 2009
3ELP
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STRUCTURE OF CYSTATIONINE GAMMA LYASE
Descriptor:Cystathionine gamma-lyase
Authors:Sun, Q., Sivaraman, J.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S
J.Biol.Chem., 284, 2009
3HC7
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CRYSTAL STRUCTURE OF LYSIN B FROM MYCOBACTERIOPHAGE D29
Descriptor:Gene 12 protein
Authors:Sun, Q., Sacchettini, J.C.
Deposit date:2009-05-05
Release date:2009-07-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase
Mol.Microbiol., 73, 2009
3HDE
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CRYSTAL STRUCTURE OF FULL-LENGTH ENDOLYSIN R21 FROM PHAGE 21
Descriptor:Lysozyme
Authors:Sun, Q., Arockiasamy, A., McKee, E., Caronna, E., Sacchettini, J.C.
Deposit date:2009-05-07
Release date:2009-11-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Regulation of a muralytic enzyme by dynamic membrane topology.
Nat.Struct.Mol.Biol., 16, 2009
3HDF
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CRYSTAL STRUCTURE OF TRUNCATED ENDOLYSIN R21 FROM PHAGE 21
Descriptor:Lysozyme, NITRATE ION, GLYCEROL
Authors:Sun, Q., Sacchettini, J.C.
Deposit date:2009-05-07
Release date:2009-11-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Regulation of a muralytic enzyme by dynamic membrane topology.
Nat.Struct.Mol.Biol., 16, 2009
3LYE
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CRYSTAL STRUCTURE OF OXALOACETATE ACETYLHYDROLASE
Descriptor:Oxaloacetate acetyl hydrolase, CALCIUM ION
Authors:Herzberg, O., Chen, C.
Deposit date:2010-02-26
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of oxalacetate acetylhydrolase, a virulence factor of the chestnut blight fungus.
J.Biol.Chem., 285, 2010
3M0J
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STRUCTURE OF OXALOACETATE ACETYLHYDROLASE IN COMPLEX WITH THE INHIBITOR 3,3-DIFLUOROOXALACETATE
Descriptor:Oxaloacetate acetyl hydrolase, 2,2-difluoro-3,3-dihydroxybutanedioic acid, MANGANESE (II) ION, ...
Authors:Herzberg, O., Chen, C.
Deposit date:2010-03-03
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of oxalacetate acetylhydrolase, a virulence factor of the chestnut blight fungus.
J.Biol.Chem., 285, 2010
3M0K
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STRUCTURE OF OXALOACETATE ACETYLHYDROLASE IN COMPLEX WITH THE PRODUCT OXALATE
Descriptor:Oxaloacetate acetylhydrolase, OXALATE ION, MANGANESE (II) ION, ...
Authors:Herzberg, O., Chen, C.
Deposit date:2010-03-03
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of oxalacetate acetylhydrolase, a virulence factor of the chestnut blight fungus.
J.Biol.Chem., 285, 2010
3OB1
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CRYSTAL STRUCTURE OF C-CBL TKB DOMAIN IN COMPLEX WITH DOUBLE PHOSPHORYLATED SPRY2 PEPTIDE
Descriptor:12-meric peptide from Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL
Authors:Sun, Q., Sivaraman, J.
Deposit date:2010-08-06
Release date:2010-08-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
3OB2
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CRYSTAL STRUCTURE OF C-CBL TKB DOMAIN IN COMPLEX WITH DOUBLE PHOSPHORYLATED EGFR PEPTIDE
Descriptor:12-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Sun, Q., Sivaraman, J.
Deposit date:2010-08-06
Release date:2010-08-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
3PLF
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REVERSE BINDING MODE OF METRD PEPTIDE COMPLEXED WITH C-CBL TKB DOMAIN
Descriptor:MetRD peptide, E3 ubiquitin-protein ligase CBL, CALCIUM ION, ...
Authors:Sun, Q., Sivaraman, J.
Deposit date:2010-11-15
Release date:2010-12-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
Febs Lett., 585, 2011
3S5J
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2.0A CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE 1
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2011-05-23
Release date:2012-05-23
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
3S9I
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 2-4-DIOXO-4-PHENYLBUTANOIC ACID INHIBITOR
Descriptor:Malate synthase G, 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MAGNESIUM ION
Authors:Krieger, I.V., Sun, Q., Sacchettini, J.C., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-01
Release date:2012-11-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
3S9Z
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 4-(2-BROMOPHENYL)-2,4-DIOXOBUTANOIC ACID INHIBITOR
Descriptor:Malate synthase G, MAGNESIUM ION, 4-(2-bromophenyl)-2,4-dioxobutanoic acid
Authors:Krieger, I.V., Sun, Q., Sacchettini, J.C., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-02
Release date:2012-11-07
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
3SAD
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 4-(2-MEHTYLPHENYL)-2,4-DIOXOBUTANOIC ACID INHIBITOR
Descriptor:Malate synthase G, MAGNESIUM ION, 4-(2-methylphenyl)-2,4-dioxobutanoic acid
Authors:Krieger, I.V., Sun, Q., Sacchettini, J.C., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-02
Release date:2012-11-07
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
3SAZ
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 4-(3-BROMOPHENYL)-2,4-DIOXOBUTANOIC ACID INHIBITOR
Descriptor:Malate synthase G, 4-(3-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION
Authors:Krieger, I.V., Sun, Q., Sacchettini, J.C., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-03
Release date:2012-11-07
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
3SB0
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MALATE SYNTHASE IN COMPLEX WITH 4-(2-CHLORO-6-FLUORO-3-METHYLPHENYL)-2,4-DIOXOBUTANOIC ACID INHIBITOR
Descriptor:Malate synthase G, MAGNESIUM ION, 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid
Authors:Krieger, I.V., Sun, Q., Sacchettini, J.C., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-03
Release date:2012-11-07
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012