Author results

2NN2
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CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM THE LRF/ZBTB7 TRANSCRIPTIONAL REGULATOR
Descriptor:Zinc finger and BTB domain-containing protein 7A
Authors:Stogios, P.J., Chen, L., Prive, G.G.
Deposit date:2006-10-23
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator.
Protein Sci., 16, 2007
3M4T
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CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM KAISO/ZBTB33, FORM I
Descriptor:Transcriptional regulator Kaiso, SULFATE ION
Authors:Stogios, P.J., Chen, L., Prive, G.G.
Deposit date:2010-03-11
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the BTB domain from Kaiso/ZBTB33, form I
TO BE PUBLISHED
3M52
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CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM THE MIZ-1/ZBTB17 TRANSCRIPTION REGULATOR
Descriptor:Zinc finger and BTB domain-containing protein 17, ZINC ION, ACETATE ION
Authors:Stogios, P.J., Cuesta-Seijo, J.A., Chen, L., Prive, G.G.
Deposit date:2010-03-12
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Insights into Strand Exchange in BTB Domain Dimers from the Crystal Structures of FAZF and Miz1.
J.Mol.Biol., 400, 2010
3M5B
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CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM FAZF/ZBTB32
Descriptor:Zinc finger and BTB domain-containing protein 32
Authors:Stogios, P.J., Pomroy, N.C., Prive, G.G.
Deposit date:2010-03-12
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into Strand Exchange in BTB Domain Dimers from the Crystal Structures of FAZF and Miz1.
J.Mol.Biol., 400, 2010
3TYK
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(4)-IA
Descriptor:Hygromycin-B 4-O-kinase, HYGROMYCIN B VARIANT, CHLORIDE ION
Authors:Stogios, P.J., Shabalin, I.G., Shakya, T., Evdokmova, E., Fan, Y., Chruszcz, M., Minor, W., Wright, G.D., Savchenko, A., Anderson, W.F., Midwest Center for Structural Genomics (MCSG)
Deposit date:2011-09-26
Release date:2011-10-12
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.
J.Biol.Chem., 286, 2011
3TYR
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CRYSTAL STRUCTURE OF TRANSCRIPTIONAL REGULATOR VANUG, FORM I
Descriptor:Transcriptional regulator
Authors:Stogios, P.J., Evdokimova, E., Wawrzak, Z., Dong, A., Depardieu, F., Courvalin, P., Shabalin, I., Chruszcz, M., Minor, W., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-09-26
Release date:2011-10-12
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Crystal structure of transcriptional regulator VanUg, Form I
TO BE PUBLISHED
3TYS
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CRYSTAL STRUCTURE OF TRANSCRIPTIONAL REGULATOR VANUG, FORM II
Descriptor:Predicted transcriptional regulator
Authors:Stogios, P.J., Evdokimova, E., Wawrzak, Z., Depardieu, F., Courvalin, P., Shabalin, I., Chruszcz, M., Minor, W., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-09-26
Release date:2011-10-12
Method:X-RAY DIFFRACTION (1.121 Å)
Cite:Crystal structure of transcriptional regulator VanUg, Form II
TO BE PUBLISHED
3UZR
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(2'')-IB, APO FORM
Descriptor:Aminoglycoside phosphotransferase, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Stogios, P.J., Minasov, G., Singer, A.U., Tan, K., Nocek, B., Evdokimova, E., Egorova, E., Di Leo, R., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-12-07
Release date:2011-12-21
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of aminoglycoside phosphotransferase APH(2'')-Ib, apo form
TO BE PUBLISHED
3V75
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CRYSTAL STRUCTURE OF PUTATIVE OROTIDINE 5'-PHOSPHATE DECARBOXYLASE FROM STREPTOMYCES AVERMITILIS MA-4680
Descriptor:Orotidine 5'-phosphate decarboxylase
Authors:Stogios, P.J., Xu, X., Cui, H., Kudritska, M., Tan, K., Edwards, A., Savchenko, A., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2011-12-20
Release date:2012-05-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of putative orotidine 5'-phosphate decarboxylase from Streptomyces avermitilis ma-4680
To be Published
3VCX
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CRYSTAL STRUCTURE OF A PUTATIVE GLYOXALASE/BLEOMYCIN RESISTANCE PROTEIN FROM RHODOPSEUDOMONAS PALUSTRIS CGA009
Descriptor:Glyoxalase/Bleomycin resistance protein/dioxygenase domain, TETRAETHYLENE GLYCOL
Authors:Stogios, P.J., Chang, C., Evdokimova, E., Egorova, O., Joachimiak, A., Edwards, A.M., Savchenko, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2012-01-04
Release date:2012-01-18
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Crystal structure of a putative glyoxalase/bleomycin resistance protein from Rhodopseudomonas palustris CGA009
To be Published
4DCA
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(2'')-IB, ADP-BOUND
Descriptor:Aminoglycoside phosphotransferase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Stogios, P.J., Minasov, G., Singer, A.U., Tan, K., Nocek, B., Evdokimova, E., Egorova, O., Di Leo, R., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-01-17
Release date:2012-02-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of aminoglycoside phosphotransferase APH(2'')-Ib, ADP-bound
TO BE PUBLISHED
4E8O
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE ANTIBIOTIC 6'-N-ACETYLTRANSFERASE AAC(6')-IH FROM ACINETOBACTER BAUMANNII
Descriptor:Aac(6')-Ih protein, CHLORIDE ION
Authors:Stogios, P.J., Minasov, G., Dong, A., Evdokimova, E., Yim, V., Courvalin, P., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-03-20
Release date:2012-04-04
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (2.138 Å)
Cite:Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.
ACS Infect Dis., 3, 2017
4EBJ
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE 4'-O-ADENYLYLTRANSFERASE ANT(4')-IIB, APO
Descriptor:Aminoglycoside nucleotidyltransferase, 1,2-ETHANEDIOL, SULFATE ION
Authors:Stogios, P.J., Wawrzak, Z., Minasov, G., Evdokimova, E., Egorova, O., Yim, V., Kudritska, M., Courvalin, P., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-03-23
Release date:2012-04-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb, apo
To be Published
4EBK
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE 4'-O-ADENYLYLTRANSFERASE ANT(4')-IIB, TOBRAMYCIN-BOUND
Descriptor:Aminoglycoside nucleotidyltransferase, TOBRAMYCIN, 1,2-ETHANEDIOL, ...
Authors:Stogios, P.J., Dong, A., Minasov, G., Evdokimova, E., Egorova, O., Yim, V., Kudritska, M., Courvalin, P., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-03-23
Release date:2012-04-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb, tobramycin-bound
To be Published
4EJ7
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CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, ATP-BOUND
Descriptor:Aminoglycoside 3'-phosphotransferase AphA1-IAB, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ...
Authors:Stogios, P.J., Minasov, G., Tan, K., Evdokimova, E., Egorova, O., Di Leo, R., Shakya, T., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-04-06
Release date:2012-04-18
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013
4EVY
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE ANTIBIOTIC 6'-N-ACETYLTRANSFERASE AAC(6')-IG FROM ACINETOBACTER HAEMOLYTICUS IN COMPLEX WITH TOBRAMYCIN
Descriptor:Aminoglycoside N(6')-acetyltransferase type 1, TOBRAMYCIN, POTASSIUM ION, ...
Authors:Stogios, P.J., Evdokimova, E., Minasov, G., Yim, V., Courvalin, P., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-04-26
Release date:2012-05-09
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (1.768 Å)
Cite:Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.
ACS Infect Dis., 3, 2017
4EXL
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CRYSTAL STRUCTURE OF PHOSPHATE ABC TRANSPORTER, PERIPLASMIC PHOSPHATE-BINDING PROTEIN PSTS 1 (PBP1) FROM STREPTOCOCCUS PNEUMONIAE CANADA MDR_19A
Descriptor:Phosphate-binding protein pstS 1, MAGNESIUM ION, CHLORIDE ION
Authors:Stogios, P.J., Wawrzak, Z., Kudritska, M., Minasov, G., Yim, V., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-04-30
Release date:2012-05-30
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of phosphate ABC transporter, periplasmic phosphate-binding protein PstS 1 (PBP1) from Streptococcus pneumoniae Canada MDR_19A
To be Published
4F0Y
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE ANTIBIOTIC 6'-N-ACETYLTRANSFERASE AAC(6')-IG FROM ACINETOBACTER HAEMOLYTICUS, APO
Descriptor:Aminoglycoside N(6')-acetyltransferase type 1, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Stogios, P.J., Evdokimova, E., Dong, A., Minasov, G., Yim, V., Courvalin, P., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-05-05
Release date:2012-05-16
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.
ACS Infect Dis., 3, 2017
4FEU
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CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, WITH SUBSTRATE KANAMYCIN AND SMALL MOLECULE INHIBITOR ANTHRAPYRAZOLONE SP600125
Descriptor:Aminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, ...
Authors:Stogios, P.J., Evdokimova, E., Wawrzak, Z., Minasov, G., Egorova, O., Di Leo, R., Shakya, T., Spanogiannopoulos, P., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-05-30
Release date:2012-06-20
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013
4FEV
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CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, WITH SUBSTRATE KANAMYCIN AND SMALL MOLECULE INHIBITOR PYRAZOLOPYRIMIDINE PP1
Descriptor:Aminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, ...
Authors:Stogios, P.J., Evdokimova, E., Wawrzak, Z., Minasov, G., Egorova, O., Di Leo, R., Shakya, T., Spanogiannopoulos, P., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-05-30
Release date:2012-06-20
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013
4FEW
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CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, WITH SUBSTRATE KANAMYCIN AND SMALL MOLECULE INHIBITOR PYRAZOLOPYRIMIDINE PP2
Descriptor:Aminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, ...
Authors:Stogios, P.J., Evdokimova, E., Wawrzak, Z., Minasov, G., Egorova, O., Di Leo, R., Shakya, T., Spanogiannopoulos, P., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-05-30
Release date:2012-06-20
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013
4FEX
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CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, WITH SUBSTRATE KANAMYCIN AND SMALL MOLECULE INHIBITOR TYRPHOSTIN AG1478
Descriptor:Aminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine, ...
Authors:Stogios, P.J., Evdokimova, E., Wawrzak, Z., Minasov, G., Egorova, O., Di Leo, R., Shakya, T., Spanogiannopoulos, P., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-05-30
Release date:2012-06-20
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013
4FO1
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CRYSTAL STRUCTURE OF LINCOSAMIDE ANTIBIOTIC ADENYLYLTRANSFERASE LNUA, APO
Descriptor:Lincosamide resistance protein, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Stogios, P.J., Wawrzak, Z., Minasov, G., Evdokimova, E., Egorova, O., Kudritska, M., Yim, V., Courvalin, P., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-06-20
Release date:2012-07-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of lincosamide antibiotic adenylyltransferase LnuA, apo
TO BE PUBLISHED
4GKH
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CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, WITH SUBSTRATE KANAMYCIN AND SMALL MOLECULE INHIBITOR 1-NA-PP1
Descriptor:Aminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ...
Authors:Stogios, P.J., Evdokimova, E., Wawrzak, Z., Minasov, G., Egorova, O., Di Leo, R., Shakya, T., Spanogiannopoulos, P., Todorovic, N., Capretta, A., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-08-11
Release date:2012-09-05
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.863 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013
4GKI
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CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE PHOSPHOTRANSFERASE APH(3')-IA, WITH SUBSTRATE KANAMYCIN AND SMALL MOLECULE INHIBITOR 1-NM-PP1
Descriptor:Aminoglycoside 3'-phosphotransferase AphA1-IAB, KANAMYCIN A, 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ...
Authors:Stogios, P.J., Evdokimova, E., Wawrzak, Z., Minasov, G., Egorova, O., Di Leo, R., Shakya, T., Spanogiannopoulos, P., Todorovic, N., Capretta, A., Wright, G.D., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-08-11
Release date:2012-09-05
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.
Biochem.J., 454, 2013