7KES

Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in complex with apramycin and CoA

Summary for 7KES

Entry DOI	10.2210/pdb7kes/pdb
Related	5HT0 6mmz 6mn0 6mn1 6mn2
Descriptor	Aminoglycoside N(3)-acetyltransferase, GLYCEROL, COENZYME A, ... (6 entities in total)
Functional Keywords	antibiotic_nat family, acetyltransferase, aminoglycoside, antibiotic resistance, metagenome, soil, csgid, transferase, center for structural genomics of infectious diseases, national institute of allergy and infectious diseases, niaid, transferase-antibiotic complex, transferase/antibiotic
Biological source	uncultured bacterium
Total number of polymer chains	2
Total formula weight	60326.75
Authors	Stogios, P.J.,Skarina, T.,Michalska, K.,Xu, Z.,Yim, V.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-10-12, release date: 2020-10-21, Last modification date: 2023-10-18)
Primary citation	Stogios, P.J.,Bordeleau, E.,Xu, Z.,Skarina, T.,Evdokimova, E.,Chou, S.,Diorio-Toth, L.,D'Souza, A.W.,Patel, S.,Dantas, G.,Wright, G.D.,Savchenko, A. Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Commun Biol, 5:263-263, 2022 Cited by PubMed: 35338238 DOI: 10.1038/s42003-022-03219-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.36 Å)

Structure validation