Author results

3QC1
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PROTEIN PHOSPHATASE SUBUNIT: ALPHA4
Descriptor:Immunoglobulin-binding protein 1
Authors:Spiller, B.W., LeNoue-Newton, M.L., Watkins, G.R., Germane, K.L., Zhou, P., McCorvey, L.R., Wadzinski, B.E.
Deposit date:2011-01-14
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The Mid1 and PP2Ac binding domains of Alpha4 are both required for Alpha4 to inhibit PP2Ac degradation
TO BE PUBLISHED
4XNQ
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ANTIBODY HEMAGGLUTININ COMPLEXES
Descriptor:H5.3 Light chain, H5.3 heavy chain, Influenza H5 HA head domain VietNam rdt mutations, ...
Authors:Spiller, B.W., Winarski, K.L.
Deposit date:2015-01-15
Release date:2015-07-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.
Proc.Natl.Acad.Sci.USA, 112, 2015
3P2D
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CRYSTAL STRUCTURE OF ARRESTIN-3 REVEALS THE BASIS OF THE DIFFERENCE IN RECEPTOR BINDING BETWEEN TWO NON-VISUAL SUBTYPES
Descriptor:Beta-arrestin-2
Authors:Spiller, B.W., Gurevich, V.V., Zhan, X., Gimenez, L.E.
Deposit date:2010-10-01
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes.
J.Mol.Biol., 406, 2011
3Q1C
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STRUCTURE OF ESPG PROTEIN
Descriptor:LEE-encoded effector EspG
Authors:Spiller, B.W., Germane, K.L.
Deposit date:2010-12-17
Release date:2011-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.596 Å)
Cite:Structural and Functional Studies Indicate That the EPEC Effector, EspG, Directly Binds p21-Activated Kinase.
Biochemistry, 50, 2011
4ELD
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CRYSTAL STRUCTURE OF AN ACTIVATED VARIANT OF SMALL HEAT SHOCK PROTEIN HSP16.5
Descriptor:Small heat shock protein HSP16.5
Authors:Spiller, B.W., Mchaourab, H.S., Lin, Y.-L.
Deposit date:2012-04-10
Release date:2012-06-13
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Crystal structure of an activated variant of small heat shock protein hsp16.5.
Biochemistry, 51, 2012
4GSD
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H5.3 FAB STRUCTURE
Descriptor:H5.3 Fab Light Chain, H5.3 Fab Heavy Chain
Authors:Spiller, B.W., Winarski, K.L.
Deposit date:2012-08-27
Release date:2013-08-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses.
J.Clin.Invest., 123, 2013
4HFW
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ANTI ROTAVIRUS ANTIBODY
Descriptor:6-26 Fab Light chain, 6-26 Fab Heavy chain, SULFATE ION
Authors:Spiller, B.W., Aiyegbo, M., Crowe, J.E.
Deposit date:2012-10-05
Release date:2013-05-29
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore.
Plos One, 8, 2013
4XRC
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ANTIBODY HEMAGGLUTININ COMPLEXES
Descriptor:H5.3 Fab light chain, H5.3 Fab heavy chain, Hemagglutinin, ...
Authors:Spiller, B.W., Winarski, K.L.
Deposit date:2015-01-20
Release date:2015-07-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.
Proc.Natl.Acad.Sci.USA, 112, 2015
3EB8
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VIRA
Descriptor:Cysteine protease-like virA
Authors:Germane, K.L., Spiller, B.W.
Deposit date:2008-08-27
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules.
Biochemistry, 47, 2008
4NRH
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COPN-SCC3 COMPLEX
Descriptor:CopN, Chaperone SycD, SODIUM ION
Authors:Archuleta, T.L., Spiller, B.W.
Deposit date:2013-11-26
Release date:2014-10-15
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A gatekeeper chaperone complex directs translocator secretion during type three secretion.
Plos Pathog., 10, 2014
4R04
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CLOSTRIDIUM DIFFICILE TOXIN A (TCDA)
Descriptor:Toxin A, ZINC ION
Authors:Lacy, D.B., Spiller, B.W., Rutherford, S.A.
Deposit date:2014-07-29
Release date:2016-01-06
Method:X-RAY DIFFRACTION (3.26 Å)
Cite:Glucosyl Transferase Structure
Nat Microbiol, 2016
5UMI
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CLOSTRIDIUM DIFFICILE TCDA-CROPS BOUND TO PA50 FAB
Descriptor:Toxin A, PA50 Fab Light chain, PA50 Fab Heavy chain
Authors:Kroh, H.K., Chandrasekaran, R., Rosenthal, K., Woods, R., Jin, X., Ohi, M.D., Nyborg, A.C., Rainey, G.J., Warrener, P., Spiller, B.W., Lacy, D.B.
Deposit date:2017-01-27
Release date:2017-07-19
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.
J. Biol. Chem., 292, 2017
5VQM
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CLOSTRIDIUM DIFFICILE TCDB-GTD BOUND TO PA41 FAB
Descriptor:Toxin B, PA41 FAB LIGHT CHAIN, PA41 FAB HEAVY CHAIN
Authors:Kroh, H.K., Spiller, B.W., Lacy, D.B.
Deposit date:2017-05-09
Release date:2017-12-06
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.
J. Biol. Chem., 293, 2018
1A4J
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DIELS ALDER CATALYTIC ANTIBODY GERMLINE PRECURSOR
Descriptor:IMMUNOGLOBULIN, DIELS ALDER CATALYTIC ANTIBODY (LIGHT CHAIN), DIELS ALDER CATALYTIC ANTIBODY (HEAVY CHAIN)
Authors:Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C.
Deposit date:1998-01-30
Release date:1998-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science, 279, 1998
1A4K
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DIELS ALDER CATALYTIC ANTIBODY WITH TRANSITION STATE ANALOGUE
Descriptor:ANTIBODY FAB, CADMIUM ION, [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID
Authors:Spiller, B.W., Romesburg, F.E., Schultz, P.G., Stevens, R.C.
Deposit date:1998-01-30
Release date:1998-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science, 279, 1998
4XNM
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ANTIBODY INFLUENZA H5 COMPLEX
Descriptor:H5.3 FAB Light Chain, H5.3 FAB Heavy Chain, Hemagglutinin, ...
Authors:Winarski, K.L., Spiler, B.W.
Deposit date:2015-01-15
Release date:2015-07-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.
Proc.Natl.Acad.Sci.USA, 112, 2015
3SRZ
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CLOSTRIDIUM DIFFICILE TOXIN A (TCDA) GLUCOLSYLTRANSFERASE DOMAIN BOUND TO UDP-GLUCOSE
Descriptor:Toxin A, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Pruitt, R.N., Chumbler, N.M., Farrow, M.A., Seeback, S.A., Friedman, D.B., Spiller, B.W., Lacy, D.B.
Deposit date:2011-07-07
Release date:2012-02-01
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
3SS1
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CLOSTRIDIUM DIFFICILE TOXIN A (TCDA) GLUCOLSYLTRANSFERASE DOMAIN
Descriptor:Toxin A, MANGANESE (II) ION
Authors:Pruitt, R.N., Chumbler, N.M., Farrow, M.A., Seeback, S.A., Friedman, D.B., Spiller, B.W., Lacy, D.B.
Deposit date:2011-07-07
Release date:2012-02-01
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity.
J.Biol.Chem., 287, 2012
3MPP
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BOTULINUM NEUROTOXIN TYPE G RECEPTOR BINDING DOMAIN
Descriptor:Botulinum neurotoxin type G
Authors:Schmitt, J.M., Lacy, D.B.
Deposit date:2010-04-27
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural analysis of botulinum neurotoxin type G receptor binding .
Biochemistry, 49, 2010