5UMI

Clostridium difficile TcdA-CROPs bound to PA50 Fab

Summary for 5UMI

• Entry DOI: 10.2210/pdb5umi/pdb
• Descriptor: Toxin A, PA50 Fab Light chain, PA50 Fab Heavy chain (3 entities in total)
• Functional Keywords: toxin antibody, toxin-immune system complex, toxin/immune system
• Biological source: Clostridioides difficile; More
• Total number of polymer chains: 5
• Total formula weight: 123971.21

Authors

Kroh, H.K.,Chandrasekaran, R.,Rosenthal, K.,Woods, R.,Jin, X.,Ohi, M.D.,Nyborg, A.C.,Rainey, G.J.,Warrener, P.,Spiller, B.W.,Lacy, D.B. (deposition date: 2017-01-27, release date: 2017-07-19, Last modification date: 2023-10-04)

• Primary citation: Kroh, H.K.,Chandrasekaran, R.,Rosenthal, K.,Woods, R.,Jin, X.,Ohi, M.D.,Nyborg, A.C.,Rainey, G.J.,Warrener, P.,Spiller, B.W.,Lacy, D.B.; Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.; J. Biol. Chem., 292:14401-14412, 2017; PubMed: 28705932; DOI: 10.1074/jbc.M117.781112

Experimental method

X-RAY DIFFRACTION (3.23 Å)