Author results

1QZ8
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS NSP9
Descriptor:polyprotein 1ab, SULFATE ION
Authors:Egloff, M.P., Ferron, F., Campanacci, V., Longhi, S., Rancurel, C., Dutartre, H., Snijder, E.J., Gorbalenya, A.E., Cambillau, C., Canard, B.
Deposit date:2003-09-16
Release date:2004-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world.
Proc.Natl.Acad.Sci.USA, 101, 2004
1MBM
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NSP4 PROTEINASE FROM EQUINE ARTERITIS VIRUS
Descriptor:chymotrypsin-like serine protease
Authors:Barrette-Ng, I.H., Ng, K.K.-S., Mark, B.L., van Aken, D., Cherney, M.M., Garen, C., Kolodenko, Y., Gorbalenya, A.E., Snijder, E.J., James, M.N.G.
Deposit date:2002-08-03
Release date:2002-10-23
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Arterivirus nsp4: the smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole
J.Biol.Chem., 277, 2002
3GZF
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STRUCTURE OF THE C-TERMINAL DOMAIN OF NSP4 FROM FELINE CORONAVIRUS
Descriptor:Replicase polyprotein 1ab, SULFATE ION
Authors:Manolaridis, I., Wojdyla, J.A., Panjikar, S., Snijder, E.J., Gorbalenya, A.E., Coutard, B., Tucker, P.A.
Deposit date:2009-04-07
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.756 Å)
Cite:Structure of the C-terminal domain of nsp4 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
2L8K
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NMR STRUCTURE OF THE ARTERIVIRUS NONSTRUCTURAL PROTEIN 7 ALPHA (NSP7 ALPHA)
Descriptor:Non-structural protein 7
Authors:Conte, M.R., Gaudin, C., Manolaridis, I., Tucker, P.W., Kelly, G.
Deposit date:2011-01-19
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7{alpha}.
J.Virol., 85, 2011
3EJF
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CRYSTAL STRUCTURE OF IBV X-DOMAIN AT PH 8.5
Descriptor:Non-structural protein 3
Authors:Piotrowski, Y., Hansen, G., Hilgenfeld, R.
Deposit date:2008-09-18
Release date:2008-09-30
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property.
Protein Sci., 18, 2009
3EJG
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CRYSTAL STRUCTURE OF HCOV-229E X-DOMAIN
Descriptor:Non-structural protein 3
Authors:Piotrowski, Y., Hansen, G., Hilgenfeld, R.
Deposit date:2008-09-18
Release date:2008-09-30
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property.
Protein Sci., 18, 2009
3EKE
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CRYSTAL STRUCTURE OF IBV X-DOMAIN AT PH 5.6
Descriptor:Non-structural protein 3, L(+)-TARTARIC ACID
Authors:Piotrowski, Y., Hansen, G., Hilgenfeld, R.
Deposit date:2008-09-19
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property.
Protein Sci., 18, 2009
3ETI
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STRUCTURE OF A CUBIC CRYSTAL FORM OF X (ADRP) DOMAIN FROM FCOV
Descriptor:macro domain of Non-structural protein 3
Authors:Wojdyla, J.A., Manolaridis, I., Tucker, P.A.
Deposit date:2008-10-08
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
3EW5
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STRUCTURE OF THE TETRAGONAL CRYSTAL FORM OF X (ADRP) DOMAIN FROM FCOV
Descriptor:macro domain of Non-structural protein 3, CHLORIDE ION, SULFATE ION, ...
Authors:Wojdyla, J.A., Manolaridis, I., Tucker, P.A.
Deposit date:2008-10-14
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
3JZT
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STRUCTURE OF A CUBIC CRYSTAL FORM OF X (ADRP) DOMAIN FROM FCOV WITH ADP-RIBOSE
Descriptor:macro domain of Non-structural protein 3, CHLORIDE ION, ADENOSINE-5-DIPHOSPHORIBOSE, ...
Authors:Wojdyla, J.A., Manolaridis, I., Tucker, P.A.
Deposit date:2009-09-24
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.91 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
3MP2
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CRYSTAL STRUCTURE OF TRANSMISSIBLE GASTROENTERITIS VIRUS PAPAIN-LIKE PROTEASE 1
Descriptor:Non-structural protein 3, ZINC ION
Authors:Wojdyla, J.A., Manolaridis, I., Tucker, P.A.
Deposit date:2010-04-24
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates.
J.Virol., 84, 2010
4IUM
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EQUINE ARTERITIS VIRUS PAPAIN-LIKE PROTEASE 2 (PLP2) COVALENTLY BOUND TO UBIQUITIN
Descriptor:papain-like protease 2, Ubiquitin, ZINC ION, ...
Authors:Bailey-Elkin, B.A., James, T.W., Mark, B.L.
Deposit date:2013-01-21
Release date:2013-02-13
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.
Proc.Natl.Acad.Sci.USA, 110, 2013
4N0N
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CRYSTAL STRUCTURE OF ARTERIVIRUS NONSTRUCTURAL PROTEIN 10 (HELICASE)
Descriptor:Replicase polyprotein 1ab, ZINC ION, SULFATE ION, ...
Authors:Deng, Z., Chen, Z.
Deposit date:2013-10-02
Release date:2014-01-08
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
Nucleic Acids Res., 42, 2014
4N0O
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COMPLEX STRUCTURE OF ARTERIVIRUS NONSTRUCTURAL PROTEIN 10 (HELICASE) WITH DNA
Descriptor:Replicase polyprotein 1ab, DNA, ZINC ION, ...
Authors:Deng, Z., Chen, Z.
Deposit date:2013-10-02
Release date:2014-01-08
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
Nucleic Acids Res., 42, 2014
4REZ
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CRYSTAL STRUCTURE OF THE MIDDLE-EAST RESPIRATORY SYNDROME CORONAVIRUS PAPAIN-LIKE PROTEASE
Descriptor:ORF1ab protein, ZINC ION, S-1,2-PROPANEDIOL
Authors:Bailey-Elkin, B.A., Johnson, G.G., Mark, B.L.
Deposit date:2014-09-24
Release date:2014-10-22
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression.
J.Biol.Chem., 289, 2014
4RF0
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CRYSTAL STRUCTURE OF THE MIDDLE-EAST RESPIRATORY SYNDROME CORONAVIRUS PAPAIN-LIKE PROTEASE IN COMPLEX WITH UBIQUITIN (SPACE GROUP P6522)
Descriptor:ORF1ab protein, Ubiquitin-60S ribosomal protein L40, ZINC ION, ...
Authors:Bailey-Elkin, B.A., Johnson, G.G., Mark, B.L.
Deposit date:2014-09-24
Release date:2014-10-22
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression.
J.Biol.Chem., 289, 2014
4RF1
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CRYSTAL STRUCTURE OF THE MIDDLE-EAST RESPIRATORY SYNDROME CORONAVIRUS PAPAIN-LIKE PROTEASE IN COMPLEX WITH UBIQUITIN (SPACE GROUP P63)
Descriptor:ORF1ab protein, Ubiquitin-60S ribosomal protein L40, ZINC ION, ...
Authors:Bailey-Elkin, B.A., Johnson, G.G., Mark, B.L.
Deposit date:2014-09-24
Release date:2014-10-22
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression.
J.Biol.Chem., 289, 2014
5N19
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STRUCTURE OF SARS CORONAVIRUS MAIN PROTEASE IN COMPLEX WITH THE ALPHA-KETOAMIDE (S)-N-BENZYL-3-((S)-2-CINNAMAMIDO-3-PHENYLPROPANAMIDO)-2-OXO-4-((S)-2-OXOPYRROLIDIN-3-YL)BUTANAMIDE
Descriptor:SARS coronavirus main protease, (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide, DIMETHYL SULFOXIDE
Authors:Zhang, L., Ma, Q., Hilgenfeld, R.
Deposit date:2017-02-05
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
To Be Published
5N5O
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STRUCTURE OF SARS CORONAVIRUS MAIN PROTEASE IN COMPLEX WITH THE ALPHA-KETOAMIDE (S)-N-BENZYL-3-((S)-2-CINNAMAMIDO-3-CYCLOPROPYLPROPANAMIDO)-2-OXO-4-((S)-2-OXOPYRROLIDIN-3-YL)BUTANAMIDE (CINNAMOYL-CYCLOPROPYLALANINE-GLNLACTAM-CO-CO-NH-BENZYL)
Descriptor:Replicase polyprotein 1ab, (2~{R},3~{S})-3-[[(2~{S})-3-cyclopropyl-2-[[(~{E})-3-phenylprop-2-enoyl]amino]propanoyl]amino]-2-oxidanyl-4-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-~{N}-(phenylmethyl)butanamide
Authors:Zhang, L., Hilgenfeld, R.
Deposit date:2017-02-14
Release date:2018-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
To Be Published
5NFS
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STRUCTURE OF COXSACKIEVIRUS B3 3C PROTEASE IN COMPLEX WITH THE ALPHA-KETOAMIDE (S)-N-BENZYL-3-((S)-2-CINNAMAMIDO-3-PHENYLPROPANAMIDO)-2-OXO-4-((S)-2-OXOPYRROLIDIN-3-YL)BUTANAMIDE (CINNAMOYL-PHENYLALANINE-GLNLACTAM-CO-CO-NH-BENZYL)
Descriptor:Genome polyprotein, (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide
Authors:Ma, Q., Zhang, L., Hilgenfeld, R.
Deposit date:2017-03-15
Release date:2018-05-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
To Be Published
5NH0
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STRUCTURE OF HUMAN CORONAVIRUS NL63 MAIN PROTEASE IN COMPLEX WITH THE ALPHA-KETOAMIDE TERT-BUTYL ((S)-4-(BENZYLAMINO)-3,4-DIOXO-1-((S)-2-OXOPYRROLIDIN-3-YL)B- UTAN-2-YL)CARBAMATE (TERT-BUTYL -GLNLACTAM-CO-CO-NH-BENZYL)
Descriptor:Replicase polyprotein 1ab, ~{tert}-butyl ~{N}-[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]carbamate, DIMETHYL SULFOXIDE, ...
Authors:Zhang, L., Hilgenfeld, R.
Deposit date:2017-03-21
Release date:2018-05-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
To Be Published
6FV1
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STRUCTURE OF HUMAN CORONAVIRUS NL63 MAIN PROTEASE IN COMPLEX WITH THE ALPHA-KETOAMIDE (S)-N-((S)-4-(BENZYLAMINO)-3,4-DIOXO-1-((S)-2-OXOPYRROLIDIN-3-YL)BUTAN-2-YL)-2-CINNAMAMIDO-4-METHYLPENTANAMIDE (CINNAMOYL-LEUCINE-GLNLACTAM-CO-CO-NH-BENZYL)
Descriptor:Replicase polyprotein 1ab, (2~{S})-4-methyl-~{N}-[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide, GLYCEROL, ...
Authors:Zhang, L., Hilgenfeld, R.
Deposit date:2018-02-28
Release date:2019-03-20
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
To Be Published
6FV2
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STRUCTURE OF HUMAN CORONAVIRUS NL63 MAIN PROTEASE IN COMPLEX WITH THE ALPHA-KETOAMIDE (S)-N-BENZYL-3-((S)-2-CINNAMAMIDO-3-PHENYLPROPANAMIDO)-2-OXO-4-((S)-2-OXOPYRROLIDIN-3-YL)BUTANAMIDE (CINNAMOYL-PHENYLALANINE-GLNLACTAM-CO-CO-NH-BENZYL)
Descriptor:Replicase polyprotein 1ab, GLYCEROL, (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide
Authors:Zhang, L., Hilgenfeld, R.
Deposit date:2018-02-28
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
To Be Published
1LVO
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STRUCTURE OF CORONAVIRUS MAIN PROTEINASE REVEALS COMBINATION OF A CHYMOTRYPSIN FOLD WITH AN EXTRA ALPHA-HELICAL DOMAIN
Descriptor:Replicase, hydrolase domain, SULFATE ION, ...
Authors:Anand, K., Palm, G.J., Mesters, J.R., Siddell, S.G., Ziebuhr, J., Hilgenfeld, R.
Deposit date:2002-05-29
Release date:2002-07-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.
EMBO J., 21, 2002