5NFS

Structure of coxsackievirus B3 3C protease in complex with the alpha-ketoamide (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (cinnamoyl-phenylalanine-GlnLactam-CO-CO-NH-benzyl)

Summary for 5NFS

• Entry DOI: 10.2210/pdb5nfs/pdb
• Descriptor: Genome polyprotein, (S)-N-benzyl-3-((S)-2-cinnamamido-3-phenylpropanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butanamide (3 entities in total)
• Functional Keywords: viral protease, enterovirus, alpha-ketoamide, inhibitor, viral protein
• Biological source: Coxsackievirus B3
• Cellular location: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : Q5UEA2
• Total number of polymer chains: 1
• Total formula weight: 20998.15

Authors

Ma, Q.,Zhang, L.,Hilgenfeld, R. (deposition date: 2017-03-15, release date: 2018-05-16)

• Primary citation: Lin, D.,Zhang, L.,Kusov, Y.,Nian, Y.,Ma, Q.,Wang, J.,Leyssen, P.,Lanko, K.,Neyts, J.,de Wilde, A.,Snijder, E.J.,Liu, H.,Hilgenfeld, R.; Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)