4REZ

Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease

Summary for 4REZ

Entry DOI	10.2210/pdb4rez/pdb
Related	4RF0 4RF1
Descriptor	ORF1ab protein, ZINC ION, S-1,2-PROPANEDIOL, ... (4 entities in total)
Functional Keywords	zinc ribbon, deubiquitinase, papain-like protease, viral protein
Biological source	Human betacoronavirus 2c Jordan-N3/2012
Cellular location	Host cytoplasm, host perinuclear region . Host membrane ; Multi-pass membrane protein : M4STU1
Total number of polymer chains	1
Total formula weight	36340.15
Authors	Bailey-Elkin, B.A.,Johnson, G.G.,Mark, B.L. (deposition date: 2014-09-24, release date: 2014-10-22, Last modification date: 2024-02-28)
Primary citation	Bailey-Elkin, B.A.,Knaap, R.C.,Johnson, G.G.,Dalebout, T.J.,Ninaber, D.K.,van Kasteren, P.B.,Bredenbeek, P.J.,Snijder, E.J.,Kikkert, M.,Mark, B.L. Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. J.Biol.Chem., 289:34667-34682, 2014 Cited by PubMed: 25320088 DOI: 10.1074/jbc.M114.609644 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation