Author results

5GNV
  • Download 5gnv
  • View 5gnv
Molmil generated image of 5gnv
STRUCTURE OF PSD-95/MAP1A COMPLEX REVEALS UNIQUE TARGET RECOGNITION MODE OF MAGUK GK DOMAIN
Descriptor:Disks large homolog 4, Microtubule-associated protein 1A, SULFATE ION
Authors:Shang, Y., Xia, Y., Zhu, R., Zhu, J.
Deposit date:2016-07-25
Release date:2017-08-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain
Biochem. J., 474, 2017
5B64
  • Download 5b64
  • View 5b64
Molmil generated image of 5b64
A NOVEL BINDING MODE OF MAGUK GK DOMAIN REVEALED BY DLG GK DOMAIN IN COMPLEX WITH KIF13B MBS DOMAIN
Descriptor:DLG GK, Protein Kif13b, SULFATE ION, ...
Authors:Shang, Y., Zhu, J., Zhang, M.
Deposit date:2016-05-24
Release date:2016-10-12
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B
Structure, 24, 2016
5JXB
  • Download 5jxb
  • View 5jxb
Molmil generated image of 5jxb
PSD-95 EXTENDED PDZ3 IN COMPLEX WITH SYNGAP PBM
Descriptor:Disks large homolog 4,SynGAP
Authors:Shang, Y., Zhang, M.
Deposit date:2016-05-13
Release date:2016-09-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.
Cell, 166, 2016
5JXC
  • Download 5jxc
  • View 5jxc
Molmil generated image of 5jxc
SYNGAP COILED-COIL TRIMER
Descriptor:Ras/Rap GTPase-activating protein SynGAP
Authors:Shang, Y., Zhang, M.
Deposit date:2016-05-13
Release date:2016-09-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.
Cell, 166, 2016
3RO2
  • Download 3ro2
  • View 3ro2
Molmil generated image of 3ro2
STRUCTURES OF THE LGN/NUMA COMPLEX
Descriptor:G-protein-signaling modulator 2, peptide of Nuclear mitotic apparatus protein 1, GLYCEROL
Authors:Shang, Y., Wei, Z.
Deposit date:2011-04-25
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and G[alpha]i/LGN/NuMA pathways
Mol.Cell, 43, 2011
3UAT
  • Download 3uat
  • View 3uat
Molmil generated image of 3uat
GUANYLATE KINASE DOMAINS OF THE MAGUK FAMILY SCAFFOLD PROTEINS AS SPECIFIC PHOSPHO-PROTEIN BINDING MODULES
Descriptor:Disks large homolog 1, phosphor-LGN peptide
Authors:Shang, Y., Zhu, J., Wen, W., Zhang, M.
Deposit date:2011-10-22
Release date:2011-12-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules
Embo J., 2011
4DC2
  • Download 4dc2
  • View 4dc2
Molmil generated image of 4dc2
STRUCTURE OF PKC IN COMPLEX WITH A SUBSTRATE PEPTIDE FROM PAR-3
Descriptor:Protein kinase C iota type, Partitioning defective 3 homolog, ADENINE
Authors:Shang, Y., Wang, C., Yu, J., Zhang, M.
Deposit date:2012-01-17
Release date:2012-07-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKC iota in complex with a substrate peptide from Par-3
Structure, 20, 2012
4G2V
  • Download 4g2v
  • View 4g2v
Molmil generated image of 4g2v
STRUCTURE COMPLEX OF LGN BINDING WITH FRMPD1
Descriptor:G-protein-signaling modulator 2, peptide from FERM and PDZ domain-containing protein 1, GLYCEROL, ...
Authors:Shang, Y., Pan, Z., Wen, W., Wang, W., Zhang, M.
Deposit date:2012-07-13
Release date:2013-01-23
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and biochemical characterization of the interaction between LGN and Frmpd1
J.Mol.Biol., 425, 2013
5IZU
  • Download 5izu
  • View 5izu
Molmil generated image of 5izu
A NEW BINDING SITE OUTSIDE THE CANONICAL PDZ DOMAIN DETERMINES THE SPECIFIC INTERACTION BETWEEN SHANK AND SAPAP AND THEIR FUNCTION
Descriptor:SH3 and multiple ankyrin repeat domains protein 3, peptide from Disks large-associated protein 3
Authors:Shang, Y., Zeng, M., Zhang, M.
Deposit date:2016-03-26
Release date:2016-05-18
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function
Proc.Natl.Acad.Sci.USA, 113, 2016
3WP0
  • Download 3wp0
  • View 3wp0
Molmil generated image of 3wp0
CRYSTAL STRUCTURE OF DLG GK IN COMPLEX WITH A PHOSPHOR-LGL2 PEPTIDE
Descriptor:Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, GLYCEROL
Authors:Zhu, J., Shang, Y., Wan, Q., Xia, Y., Chen, J., Du, Q., Zhang, M.
Deposit date:2014-01-08
Release date:2014-03-19
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.039 Å)
Cite:Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
3WP1
  • Download 3wp1
  • View 3wp1
Molmil generated image of 3wp1
PHOSPHORYLATION-DEPENDENT INTERACTION BETWEEN TUMOR SUPPRESSORS DLG AND LGL
Descriptor:Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, SULFATE ION
Authors:Zhu, J., Shang, Y., Wan, Q., Xia, Y., Chen, J., Du, Q., Zhang, M.
Deposit date:2014-01-08
Release date:2014-03-19
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
5ZRX
  • Download 5zrx
  • View 5zrx
Molmil generated image of 5zrx
CRYSTAL STRUCTURE OF EPHA2/SHIP2 COMPLEX
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2,Ephrin type-A receptor 2
Authors:Wang, Y., Shang, Y., Li, J., Chen, W., Li, G., Wan, J., Liu, W., Zhang, M.
Deposit date:2018-04-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5ZRY
  • Download 5zry
  • View 5zry
Molmil generated image of 5zry
CRYSTAL STRUCTURE OF EPHA6/ODIN COMPLEX
Descriptor:Ankyrin repeat and SAM domain-containing protein 1A,Ephrin type-A receptor 6, SULFATE ION, GLYCEROL, ...
Authors:Wang, Y., Shang, Y., Li, J., Chen, W., Li, G., Wan, J., Liu, W., Zhang, M.
Deposit date:2018-04-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5ZRZ
  • Download 5zrz
  • View 5zrz
Molmil generated image of 5zrz
CRYSTAL STRUCTURE OF EPHA5/SAMD5 COMPLEX
Descriptor:Ephrin type-A receptor 5, Sterile alpha motif domain-containing protein 5
Authors:Wang, Y., Shang, Y., Li, J., Chen, W., Li, G., Wan, J., Liu, W., Zhang, M.
Deposit date:2018-04-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5YPO
  • Download 5ypo
  • View 5ypo
Molmil generated image of 5ypo
CRYSTAL STRUCTURE OF PSD-95 GK DOMAIN IN COMPLEX WITH PHOSPHO-SAPAP PEPTIDE
Descriptor:Disks large homolog 4, SAPAP, GLYCEROL
Authors:Zhu, J., Zhou, Q., Shang, Y., Weng, Z., Zhang, R., Zhang, M.
Deposit date:2017-11-02
Release date:2018-03-14
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
Cell Rep, 21, 2017
5YPR
  • Download 5ypr
  • View 5ypr
Molmil generated image of 5ypr
CRYSTAL STRUCTURE OF PSD-95 SH3-GK DOMAIN IN COMPLEX WITH A SYNTHESIZED INHIBITOR
Descriptor:Disks large homolog 4, Synthesized GK inhibitor
Authors:Zhu, J., Zhou, Q., Shang, Y., Weng, Z., Zhu, R., Zhang, M.
Deposit date:2017-11-02
Release date:2018-03-14
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
Cell Rep, 21, 2017
3O71
  • Download 3o71
  • View 3o71
Molmil generated image of 3o71
CRYSTAL STRUCTURE OF ERK2/DCC PEPTIDE COMPLEX
Descriptor:Mitogen-activated protein kinase 1, Peptide of Deleted in Colorectal Cancer, THIOCYANATE ION
Authors:Ma, W.F., Shang, Y., Wei, Z.Y., Wen, W.Y., Wang, W.N., Zhang, M.J.
Deposit date:2010-07-30
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase
Structure, 18, 2010
3RO3
  • Download 3ro3
  • View 3ro3
Molmil generated image of 3ro3
CRYSTAL STRUCTURE OF LGN/MINSCUTEABLE COMPLEX
Descriptor:G-protein-signaling modulator 2, peptide of Protein inscuteable homolog, GLYCEROL, ...
Authors:Zhu, J., Wen, W., Shang, Y., Wei, Z., Pan, Z., Wang, W., Zhang, M.
Deposit date:2011-04-25
Release date:2012-03-07
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and G[alpha]i/LGN/NuMA pathways
Mol.Cell, 43, 2011
4JHR
  • Download 4jhr
  • View 4jhr
Molmil generated image of 4jhr
AN AUTO-INHIBITED CONFORMATION OF LGN REVEALS A DISTINCT INTERACTION MODE BETWEEN GOLOCO MOTIFS AND TPR MOTIFS
Descriptor:G-protein-signaling modulator 2
Authors:Pan, Z., Zhu, J., Shang, Y., Wei, Z., Jia, M., Xia, C., Wen, W., Wang, W., Zhang, M.
Deposit date:2013-03-05
Release date:2013-06-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An autoinhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs
Structure, 21, 2013
5F67
  • Download 5f67
  • View 5f67
Molmil generated image of 5f67
AN EXQUISITELY SPECIFIC PDZ/TARGET RECOGNITION REVEALED BY THE STRUCTURE OF INAD PDZ3 IN COMPLEX WITH TRP CHANNEL TAIL
Descriptor:Inactivation-no-after-potential D protein, TRP C terminal Tail
Authors:Ye, F., Shang, Y., Liu, W., Zhang, M.
Deposit date:2015-12-05
Release date:2016-02-24
Last modified:2016-03-16
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:An Exquisitely Specific PDZ/Target Recognition Revealed by the Structure of INAD PDZ3 in Complex with TRP Channel Tail
Structure, 24, 2016
5YBE
  • Download 5ybe
  • View 5ybe
Molmil generated image of 5ybe
STRUCTURE OF KANK1/KIF21A COMPLEX
Descriptor:Kank1 protein, KIF21A, 1,2-ETHANEDIOL
Authors:Weng, Z.F., Shang, Y., Yao, D.Q., Zhu, J.W., Zhang, R.G.
Deposit date:2017-09-04
Release date:2017-11-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.111 Å)
Cite:Structural analyses of key features in the KANK1/KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex.
J. Biol. Chem., 293, 2018
4LEX
  • Download 4lex
  • View 4lex
Molmil generated image of 4lex
UNLIGANDED CRYSTAL STRUCTURE OF MAB7
Descriptor:FAB HEAVY CHAIN, FAB LIGHT CHAIN
Authors:Murray, J.M., Mukund, S.
Deposit date:2013-06-26
Release date:2013-11-13
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
J.Biol.Chem., 288, 2013
4LF3
  • Download 4lf3
  • View 4lf3
Molmil generated image of 4lf3
INHIBITORY MECHANISM OF AN ALLOSTERIC ANTIBODY TARGETING THE GLUCAGON RECEPTOR
Descriptor:Fab heavy chain, Fab light chain, Glucagon receptor
Authors:Murray, J.M., Mukund, S.
Deposit date:2013-06-26
Release date:2013-11-13
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (2.735 Å)
Cite:Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
J.Biol.Chem., 288, 2013
5C5S
  • Download 5c5s
  • View 5c5s
Molmil generated image of 5c5s
CRYSTAL STRUCTURE OF HUMAN MYOSIN 9B RHOGAP DOMAIN AT 2.2 ANGSTROM
Descriptor:Unconventional myosin-IXb
Authors:Yi, F.S., Ren, J.Q., Feng, W.
Deposit date:2015-06-22
Release date:2015-11-25
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression
J.Clin.Invest., 125, 2015
5ZYS
  • Download 5zys
  • View 5zys
Molmil generated image of 5zys
STRUCTURE OF NEPHRIN/MAGI1 COMPLEX
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, Nephrin
Authors:Weng, Z.F., Shng, Y., Zhu, J.W., Zhang, R.G.
Deposit date:2018-05-28
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling.
J. Am. Soc. Nephrol., 29, 2018