Author results

3JYH
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HUMAN DIPEPTIDYL PEPTIDASE DPP7
Descriptor:Dipeptidyl-peptidase 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Dobrovetsky, E., Dong, A., Seitova, A., Crombett, L., Paganon, S., Cossar, D., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Hassel, A., Shewchuk, L., Bochkarev, A., Structural Genomics Consortium (SGC)
Deposit date:2009-09-21
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Human dipeptidyl peptidase DPP7
To be Published
5WCG
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SET AND MYND DOMAIN CONTAINING PROTEIN 2
Descriptor:N-lysine methyltransferase SMYD2, ZINC ION, [3-(6-amino-2-methyl-9H-purin-9-yl)azetidin-1-yl]{5-[(4-cycloheptylpiperazin-1-yl)methyl]-1-methyl-1H-pyrazol-3-yl}methanone, ...
Authors:Dong, A., Zeng, H., Walker, J.R., Hutch, A., Seitova, A., Tatlock, J., Kumpf, R., Owen, A., Taylor, A., Casimiro-Garcia, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2017-08-02
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The crystal structure of SMYD2 in complex with compound MTF003
to be published
6CBX
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CRYSTAL STRUCTURE OF HUMAN SET AND MYND DOMAIN CONTAINING PROTEIN 2 WITH MTF1497
Descriptor:N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)azetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone, ...
Authors:ZENG, H., DONG, A., Hutchinson, A., Seitova, A., TATLOCK, J., KUMPF, R., OWEN, A., TAYLOR, A., Casimiro-Garcia, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-14
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
to be published
6CBY
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CRYSTAL STRUCTURE OF HUMAN SET AND MYND DOMAIN CONTAINING PROTEIN 2 WITH MTF9975
Descriptor:N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone
Authors:ZENG, H., DONG, A., Hutchinson, A., Seitova, A., TATLOCK, J., KUMPF, R., OWEN, A., TAYLOR, A., Casimiro-Garcia, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975
to be published
2ITL
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THE ORIGIN BINDING DOMAIN OF THE SV40 LARGE T ANTIGEN BOUND TO THE FUNCTIONAL PEN PALINDROME DNA (23 BP)
Descriptor:24-nt PEN element of the SV40 DNA origin, large T antigen
Authors:Bochkareva, E., Seitova, A., Bochkarev, A.
Deposit date:2006-10-19
Release date:2006-12-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of the origin-binding domain of simian virus 40 large T antigen bound to DNA
Embo J., 25, 2006
2OXE
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STRUCTURE OF THE HUMAN PANCREATIC LIPASE-RELATED PROTEIN 2
Descriptor:Pancreatic lipase-related protein 2, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Walker, J.R., Davis, T., Seitova, A., Finerty Jr., P.J., Butler-Cole, C., Kozieradzki, I., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-02-20
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation.
Biochemistry, 47, 2008
2PPL
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HUMAN PANCREATIC LIPASE-RELATED PROTEIN 1
Descriptor:Pancreatic lipase-related protein 1, CALCIUM ION, SODIUM ION
Authors:Walker, J.R., Davis, T., Seitova, A., Butler-Cole, C., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-04-30
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the Human Pancreatic Lipase-related Protein 1.
To be Published
3DLJ
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CRYSTAL STRUCTURE OF HUMAN CARNOSINE DIPEPTIDASE 1
Descriptor:Beta-Ala-His dipeptidase, ZINC ION, UNKNOWN ATOM OR ION, ...
Authors:Dong, A., Dobrovetsky, E., Seitova, A., He, H., Tempel, W., Kozieradzki, I., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Bochkarev, A., Cossar, D., Structural Genomics Consortium (SGC)
Deposit date:2008-06-27
Release date:2008-08-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of human carnosine dipeptidase 1.
To be Published
3GRO
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HUMAN PALMITOYL-PROTEIN THIOESTERASE 1
Descriptor:Palmitoyl-protein thioesterase 1, UNKNOWN ATOM OR ION
Authors:Dobrovetsky, E., Seitova, A., Tong, Y., Tempel, W., Dong, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Cossar, D., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-03-26
Release date:2009-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Human palmitoyl-protein thioesterase 1
To be Published
3ICU
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PROTEASE-ASSOCIATED DOMAIN OF THE E3 LIGASE GRAIL
Descriptor:E3 ubiquitin-protein ligase RNF128, N-ACETYL-D-GLUCOSAMINE
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2009-07-18
Release date:2009-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:PA Domain of the E3 Ligase Grail
To be Published
3KS9
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METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITH LY341495 ANTAGONIST
Descriptor:Metabotropic glutamate receptor 1, 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, MAGNESIUM ION, ...
Authors:Dobrovetsky, E., Khutoreskaya, G., Seitova, A., Cossar, D., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Bochkarev, A., Structural Genomics Consortium (SGC)
Deposit date:2009-11-20
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Metabotropic glutamate receptor mglur1 complexed with LY341495 antagonist
To be Published
3LMK
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LIGAND BINDING DOMAIN OF METABOTROPOC GLUTAMATE RECEPTOR MGLUR5 COMPLEXED WITH GLUTAMATE
Descriptor:Metabotropic glutamate receptor 5, N-ACETYL-D-GLUCOSAMINE, GLUTAMIC ACID, ...
Authors:Dobrovetsky, E., Khutoreskaya, G., Seitova, A., Cossar, D., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Bochkarev, A., Structural Genomics Consortium (SGC)
Deposit date:2010-01-30
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Metabotropic Glutamate receptor mGluR5 complexed with glutamate
To be Published
3MQ4
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METABOTROPIC GLUTAMATE RECEPTOR MGLUR7 COMPLEXED WITH LY341495 ANTAGONIST
Descriptor:Metabotropic glutamate receptor 7, MAGNESIUM ION, 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine
Authors:Dobrovetsky, E., Khutoreskaya, G., Seitova, A., He, H., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Cossar, D., Bochkarev, A., Structural Genomics Consortium (SGC)
Deposit date:2010-04-27
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:mGluR7 complexed with LY341495
To be Published
3N0T
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HUMAN DIPEPTIDIL PEPTIDASE DPP7 COMPLEXED WITH INHIBITOR GSK237826A
Descriptor:Dipeptidyl peptidase 2, (3S)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine
Authors:Dobrovetsky, E., Khutoreskaya, G., Seitova, A., Crombet, L., Cossar, D., Pagannon, S., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Hassell, A., Shewchuk, L., Haffner, C., Bochkarev, A., Structural Genomics Consortium (SGC)
Deposit date:2010-05-14
Release date:2010-07-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Human dipeptidyl peptidase DPP7
To be Published
3NRU
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LIGAND BINDING DOMAIN OF EPHA7
Descriptor:Ephrin receptor, SULFATE ION, CHLORIDE ION
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Kania, J., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S.
Deposit date:2010-06-30
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ephrin A7 ligand binding domain
To be Published
3P1I
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LIGAND BINDING DOMAIN OF HUMAN EPHRIN TYPE-B RECEPTOR 3
Descriptor:Ephrin type-B receptor 3, SULFATE ION, CHLORIDE ION
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Kania, J., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2010-09-30
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ligand Binding Domain of Human Ephb3
To be Published
3SM9
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CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3 PRECURSOR IN PRESENCE OF LY341495 ANTAGONIST
Descriptor:Metabotropic glutamate receptor 3, SULFATE ION, 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, ...
Authors:Wernimont, A.K., Dong, A., Seitova, A., Crombet, L., Khutoreskaya, G., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Weigelt, J., Cossar, D., Dobrovetsky, E., Structural Genomics Consortium (SGC)
Deposit date:2011-06-27
Release date:2011-07-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist
TO BE PUBLISHED
4QOX
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CRYSTAL STRUCTURE OF CDPK4 FROM PLASMODIUM FALCIPARUM, PF3D7_0717500
Descriptor:Calcium-dependent protein kinase 4, MAGNESIUM ION, 3-(3-bromobenzyl)-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Authors:Wernimont, A.K., Walker, J.R., Hutchinson, A., Seitova, A., He, H., Loppnau, P., Neculai, M., Amani, M., Lin, Y.H., Ravichandran, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Lovato, D.V., Structural Genomics Consortium (SGC)
Deposit date:2014-06-20
Release date:2014-09-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.748 Å)
Cite:Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500
TO BE PUBLISHED
4RGJ
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APO CRYSTAL STRUCTURE OF CDPK4 FROM PLASMODIUM FALCIPARUM, PF3D7_0717500
Descriptor:Calcium-dependent protein kinase 4
Authors:Wernimont, A.K., Walker, J.R., Hutchinson, A., Seitova, A., He, H., Loppnau, P., Neculai, M., Amani, M., Lin, Y.H., Ravichandran, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Lovato, D.V., Structural Genomics Consortium (SGC)
Deposit date:2014-09-30
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Apo crystal structure of CDPK4 from Plasmodium falciparum, PF3D7_0717500
To be Published
4RZ0
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM PUTATIVE HISTONE METHYLTRANSFERASE PFL0690C
Descriptor:PFL0690c, UNKNOWN ATOM OR ION
Authors:Jiang, D.Q., Tempel, W., Loppnau, P., Graslund, S., He, H., Ravichandran, M., Seitova, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Hutchinson, A., Lin, Y.H., Structural Genomics Consortium (SGC)
Deposit date:2014-12-17
Release date:2015-01-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.487 Å)
Cite:Crystal Structure of Plasmodium falciparum putative histone methyltransferase PFL0690c
To be Published
4RZ7
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CRYSTAL STRUCTURE OF PVX_084705 WITH BOUND PCI32765
Descriptor:cGMP-dependent protein kinase, putative, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, ...
Authors:Jiang, D.Q., Tempel, W., Loppnau, P., Graslund, S., He, H., Seitova, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Hutchinson, A., El Bakkouri, M., Amani, M., Structural Genomics Consortium (SGC)
Deposit date:2014-12-18
Release date:2015-01-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Crystal Structure of PVX_084705 with bound PCI32765
To be Published
4YY8
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CRYSTAL STRUCTURE ANALYSIS OF KELCH PROTEIN FROM PLASMODIUM FALCIPARUM
Descriptor:Kelch protein, UNKNOWN ATOM OR ION, GLYCEROL
Authors:Jiang, D.Q., Tempel, W., Loppnau, P., Graslund, S., He, H., Ravichandran, M., Seitova, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., El Bakkouri, M., Senisterra, G., Osman, K.T., Lovato, D.V., Hui, R., Hutchinson, A., Lin, Y.H., Structural Genomics Consortium (SGC)
Deposit date:2015-03-23
Release date:2015-04-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal Structure Analysis of Kelch protein from Plasmodium falciparum.
to be published
4ZGC
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CRYSTAL STRUCTURE ANALYSIS OF KELCH PROTEIN (WITH DISULFIDE BOND) FROM PLASMODIUM FALCIPARUM
Descriptor:Kelch protein, UNKNOWN ATOM OR ION
Authors:Jiang, D.Q., Tempel, W., Loppnau, P., Graslund, S., He, H., Ravichandran, M., Seitova, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., El Bakkouri, M., Senisterra, G., Osman, K.T., Lovato, D.V., Hui, R., Hutchinson, A., Lin, Y.H., Structural Genomics Consortium (SGC)
Deposit date:2015-04-22
Release date:2015-06-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of kelch protein with disulfide bond from Plasmodium falciparum.
to be published
5DYK
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CRYSTAL STRUCTURE OF THE CGMP-DEPENDENT PROTEIN KINASE PKG FROM PLASMODIUM FALCIPARUM - APO FORM
Descriptor:CGMP-dependent protein kinase, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Wernimont, A.K., Tempel, W., He, H., Seitova, A., Hills, T., Neculai, A.M., Baker, D.A., Flueck, C., Kettleborough, C.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Hutchinson, A., El Bakkouri, M., Structural Genomics Consortium (SGC)
Deposit date:2015-09-24
Release date:2015-11-04
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Proc.Natl.Acad.Sci.USA, 116, 2019
5DYL
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CRYSTAL STRUCTURE OF THE CGMP-DEPENDENT PROTEIN KINASE PKG FROM PLASMODIUM VIVAX - APO FORM
Descriptor:cGMP-dependent protein kinase, putative
Authors:Wernimont, A.K., Tempel, W., He, H., Seitova, A., Hills, T., Neculai, A.M., Baker, D.A., Flueck, C., Kettleborough, C.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Hutchinson, A., El Bakkouri, M., Structural Genomics Consortium (SGC)
Deposit date:2015-09-24
Release date:2015-11-04
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Proc.Natl.Acad.Sci.USA, 116, 2019
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