7RBQ

Co-crystal structure of human PRMT9 in complex with MT556 inhibitor

Summary for 7RBQ

• Entry DOI: 10.2210/pdb7rbq/pdb
• Descriptor: Protein arginine N-methyltransferase 9, 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: prmt9, mt556 inhibitor, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 80963.91

Authors

Zeng, H.,Dong, A.,Hutchinson, A.,Seitova, A.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2021-07-06, release date: 2021-08-11)

• Primary citation: Zeng, H.,Dong, A.,Hutchinson, A.,Seitova, A.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Co-crystal structure of human PRMT9 in complex with MT556 inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)