6WAD

Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with MT2739 inhibitor

Summary for 6WAD

• Entry DOI: 10.2210/pdb6wad/pdb
• Descriptor: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, 5-bromo-N-(diphenylmethyl)-N-methylthiophene-2-carboxamide, ... (4 entities in total)
• Functional Keywords: prmt6 and mt2739 inhibitor, structural genomics, structural genomics consortium, sgc, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 42845.28

Authors

Halabelian, L.,Zeng, H.,Dong, A.,Schapira, M.,De Freitas, R.F.,Hutchinson, A.,Seitova, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2020-03-25, release date: 2020-09-02, Last modification date: 2023-10-18)

• Primary citation: Halabelian, L.,Zeng, H.,Dong, A.,Schapira, M.,De Freitas, R.F.,Hutchinson, A.,Seitova, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC); Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with MT2739 inhibitor; to be published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)