6WAD
Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with MT2739 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein arginine N-methyltransferase 6 | polymer | 376 | 42074.6 | 1 | UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528) | Homo sapiens (Human) | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6,Histone-arginine N-methyltransferase PRMT6 |
| 2 | B (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 3 | C (A) | 5-bromo-N-(diphenylmethyl)-N-methylthiophene-2-carboxamide | non-polymer | 386.3 | 1 | Chemie (TQ7) | |||
| 4 | D (A) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 1 - 375 (UniProt: Q96LA8)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 194 | Ala 194 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42074.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 770.7 | |
| All* | Total formula weight | 42845.3 |
