1E1Z | | CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT C69S | | Descriptor: | Arylsulfatase A, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION | | Authors: | von Buelow, R., Schmidt, B., Dierks, T., von Figura, K., Uson, I. | | Deposit date: | 2000-05-12 | | Release date: | 2001-05-10 | | Last modified: | 2018-07-11 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis.
J. Mol. Biol., 305, 2001
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1E2S | | CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT C69A | | Descriptor: | Arylsulfatase A, MAGNESIUM ION, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | von Buelow, R., Schmidt, B., Dierks, T., von Figura, K., Uson, I. | | Deposit date: | 2000-05-24 | | Release date: | 2000-12-06 | | Last modified: | 2018-07-11 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis.
J. Mol. Biol., 305, 2001
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1E33 | | CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT P426L | | Descriptor: | Arylsulfatase A, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION | | Authors: | von Buelow, R., Schmidt, B., Dierks, T., von Figura, K., Uson, I. | | Deposit date: | 2000-06-06 | | Release date: | 2001-05-25 | | Last modified: | 2018-07-11 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Defective oligomerization of arylsulfatase a as a cause of its instability in lysosomes and metachromatic leukodystrophy.
J. Biol. Chem., 277, 2002
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1E3C | | CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT C69S SOAKED IN SYNTHETIC SUBSTRATE | | Descriptor: | Arylsulfatase A, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION | | Authors: | von Buelow, R., Schmidt, B., Dierks, T., von Figura, K., Uson, I. | | Deposit date: | 2000-06-13 | | Release date: | 2001-03-05 | | Last modified: | 2018-07-11 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis.
J. Mol. Biol., 305, 2001
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1E6F | | HUMAN MIR-RECEPTOR, REPEAT 11 | | Descriptor: | CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR | | Authors: | Von Buelow, R., Rajashankar, K.R., Dauter, M., Dauter, Z., Grimme, S., Schmidt, B., Von Figura, K., Uson, I. | | Deposit date: | 2000-08-15 | | Release date: | 2001-08-09 | | Last modified: | 2019-01-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Locating the Anomalous Scatterer Substructures in Halide and Sulfur Phasing
Acta Crystallogr.,Sect.D, 59, 2003
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1GQB | | HUMAN MIR-RECEPTOR, REPEAT 11 | | Descriptor: | CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, BROMIDE ION | | Authors: | Von Buelow, R., Dauter, M., Dauter, Z., Rajashankar, K.R., Grimme, S., Schmidt, B., Von Figura, K., Uson, I. | | Deposit date: | 2001-11-22 | | Release date: | 2002-12-05 | | Last modified: | 2019-01-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Locating the Anomalous Scatterer Substructures in Halide and Sulfur Phasing
Acta Crystallogr.,Sect.D, 59, 2003
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1HDH | | ARYLSULFATASE FROM PSEUDOMONAS AERUGINOSA | | Descriptor: | Arylsulfatase, CALCIUM ION, SULFATE ION | | Authors: | Boltes, I., Czapinska, H., Kahnert, A., von Buelow, R., Dirks, T., Schmidt, B., von Figura, K., Kertesz, M.A., Uson, I. | | Deposit date: | 2000-11-16 | | Release date: | 2001-11-15 | | Last modified: | 2018-06-13 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | 1.3 A Structure of Arylsulfatase from Pseudomonas Aeruginosa Establishes the Catalytic Mechanism of Sulfate Ester Cleavage in the Sulfatase Family.
Structure, 9, 2001
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3OKJ | | ALPHA-KETO-ALDEHYDE BINDING MECHANISM REVEALS A NOVEL LEAD STRUCTURE MOTIF FOR PROTEASOME INHIBITION | | Descriptor: | Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... | | Authors: | Groll, M., Poynor, M., Gallastegui, P., Stein, M., Schmidt, B., Kloetzel, P.M., Huber, R. | | Deposit date: | 2010-08-25 | | Release date: | 2011-06-08 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition
Angew.Chem.Int.Ed.Engl., 50, 2011
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4NNN | | YCP IN COMPLEX WITH MG132 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M. | | Deposit date: | 2013-11-18 | | Release date: | 2014-02-12 | | Last modified: | 2014-02-19 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4NNW | | YCP IN COMPLEX WITH Z-LEU-LEU-LEU-KETOALDEHYDE | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M. | | Deposit date: | 2013-11-19 | | Release date: | 2014-02-12 | | Last modified: | 2014-02-19 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4NO1 | | YCP IN COMPLEX WITH Z-LEU-LEU-LEU-B(OH)2 | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M. | | Deposit date: | 2013-11-19 | | Release date: | 2014-02-12 | | Last modified: | 2014-02-19 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4NO6 | | YCP IN COMPLEX WITH Z-LEU-LEU-LEU-VINYLSULFONE | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M. | | Deposit date: | 2013-11-19 | | Release date: | 2014-02-12 | | Last modified: | 2014-02-19 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4NO8 | | YCP IN COMPLEX WITH Z-LEU-LEU-LEU-KETOAMIDE | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M. | | Deposit date: | 2013-11-19 | | Release date: | 2014-02-12 | | Last modified: | 2014-02-19 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4NO9 | | YCP IN COMPLEX WITH Z-LEU-LEU-LEU-EPOXYKETONE | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M. | | Deposit date: | 2013-11-19 | | Release date: | 2014-02-12 | | Last modified: | 2014-02-19 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4R02 | | YCP IN COMPLEX WITH BSC4999 (ALPHA-KETO PHENYLAMIDE) | | Descriptor: | Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... | | Authors: | Voss, C., Scholz, C., Knorr, S., Beck, P., Stein, M., Zall, A., Kuckelkorn, U., Kloetzel, P.-M., Groll, M., Hamacher, K., Schmidt, B. | | Deposit date: | 2014-07-29 | | Release date: | 2014-08-13 | | Last modified: | 2014-11-19 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | alpha-Keto Phenylamides as P1'-Extended Proteasome Inhibitors.
Chemmedchem, 9, 2014
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5LCP | |
5LCT | |
5M0B | |
5M0C | |
5M0L | |
5M0U | |
5M6V | |
5M6Y | |
5M71 | |
5M75 | |
