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4NNW

yCP in complex with Z-Leu-Leu-Leu-ketoaldehyde

Summary for 4NNW
Entry DOI10.2210/pdb4nnw/pdb
Related1RYP 4NNN 4NO1 4NO6 4NO8 4NO9
Related PRD IDPRD_001207
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total)
Functional Keywordsproteasome, peptide electrophile, binding analysis, reversible inhibitor, ketoaldehyde, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae S288c (Baker's yeast)
More
Cellular locationCytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains28
Total formula weight734291.19
Authors
Stein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Krueger, A.,Schmidt, B.,Groll, M. (deposition date: 2013-11-19, release date: 2014-02-12, Last modification date: 2024-03-13)
Primary citationStein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Kruger, A.,Schmidt, B.,Groll, M.
Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53:1679-1683, 2014
Cited by
PubMed: 24403024
DOI: 10.1002/anie.201308984
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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