4NO1

yCP in complex with Z-Leu-Leu-Leu-B(OH)2

Summary for 4NO1

Entry DOI	10.2210/pdb4no1/pdb
Related	1RYP 4NNN 4NNW 4NO6 4NO8 4NO9
Related PRD ID	PRD_000909
Descriptor	Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total)
Functional Keywords	proteasome, peptide electrophile, binding analysis, irreversible inhibitor, boronic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Saccharomyces cerevisiae S288c (Baker's yeast) More
Total number of polymer chains	28
Total formula weight	732228.07
Authors	Stein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Krueger, A.,Schmidt, B.,Groll, M. (deposition date: 2013-11-19, release date: 2014-02-12, Last modification date: 2023-09-20)
Primary citation	Stein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Kruger, A.,Schmidt, B.,Groll, M. Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif. Angew.Chem.Int.Ed.Engl., 53:1679-1683, 2014 Cited by PubMed: 24403024 DOI: 10.1002/anie.201308984 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation