6YNA
Crystal structure of cAMP-dependent Protein Kinase (PKA) in complex with Fasudil (M77, soaked)
Summary for 6YNA
| Entry DOI | 10.2210/pdb6yna/pdb |
| Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total) |
| Functional Keywords | phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase |
| Biological source | Cricetulus griseus (Chinese hamster) More |
| Total number of polymer chains | 2 |
| Total formula weight | 43596.61 |
| Authors | Oebbeke, M.,Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2020-04-13, release date: 2020-10-14, Last modification date: 2024-01-24) |
| Primary citation | Wienen-Schmidt, B.,Oebbeke, M.,Ngo, K.,Heine, A.,Klebe, G. Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses. Chemmedchem, 16:292-300, 2021 Cited by PubMed: 33029876DOI: 10.1002/cmdc.202000565 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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