4NNN
yCP in complex with MG132
Summary for 4NNN
Entry DOI | 10.2210/pdb4nnn/pdb |
Related | 1RYP 4NNW 4NO1 4NO6 4NO8 4NO9 |
Related PRD ID | PRD_001210 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total) |
Functional Keywords | proteasome, peptide electrophile, binding analysis, reversible inhibitor, aldehyde, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae S288c (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 734111.03 |
Authors | Stein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Krueger, A.,Schmidt, B.,Groll, M. (deposition date: 2013-11-18, release date: 2014-02-12, Last modification date: 2023-09-20) |
Primary citation | Stein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Kruger, A.,Schmidt, B.,Groll, M. Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif. Angew.Chem.Int.Ed.Engl., 53:1679-1683, 2014 Cited by PubMed: 24403024DOI: 10.1002/anie.201308984 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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