yCP in complex with Z-Leu-Leu-Leu-epoxyketone

Summary for 4NO9

Related1RYP 4NNN 4NNW 4NO1 4NO6 4NO8
Related PRD IDPRD_001200 PRD_001201
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (18 entities in total)
Functional Keywordsproteasome, peptide electrophile, binding analysis, irreversible inhibitor, epoxyketone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight733386.06
Stein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Krueger, A.,Schmidt, B.,Groll, M. (deposition date: 2013-11-19, release date: 2014-02-12, Last modification date: 2014-02-19)
Primary citation
Stein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Kruger, A.,Schmidt, B.,Groll, M.
Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53:1679-1683, 2014
PubMed: 24403024 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201308984
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2053 0.5% 5.8% 1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28