6YNB

Crystal structure of cAMP-dependent Protein Kinase (PKA) in complex with short-chain Fasudil-derivative N-(2-aminoethyl)isoquinoline-5-sulfonamide (soaked)

Summary for 6YNB

• Entry DOI: 10.2210/pdb6ynb/pdb
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-(2-AMINOETHYL)ISOQUINOLINE-5-SULFONAMIDE, ... (5 entities in total)
• Functional Keywords: phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43516.50

Authors

Oebbeke, M.,Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2020-04-13, release date: 2020-10-14, Last modification date: 2024-01-24)

• Primary citation: Wienen-Schmidt, B.,Oebbeke, M.,Ngo, K.,Heine, A.,Klebe, G.; Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses.; Chemmedchem, 16:292-300, 2021; PubMed: 33029876; DOI: 10.1002/cmdc.202000565

Experimental method

X-RAY DIFFRACTION (1.72 Å)