Author results

2DAP
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C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH DAP
Descriptor:DIAMINOPIMELIC ACID DEHYDROGENASE, 2,6-DIAMINOPIMELIC ACID
Authors:Scapin, G., Cirilli, M., Reddy, S.G., Gao, Y., Vederas, J.C., Blanchard, J.S.
Deposit date:1997-12-23
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase.
Biochemistry, 37, 1998
3DAP
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C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH NADP+ AND THE INHIBITOR 5S-ISOXAZOLINE
Descriptor:DIAMINOPIMELIC ACID DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S,5',S)-2-AMINO-3-(3-CARBOXY-2-ISOXAZOLIN-5-YL)PROPANOIC ACID
Authors:Scapin, G., Cirilli, M., Reddy, S.G., Gao, Y., Vederas, J.C., Blanchard, J.S.
Deposit date:1997-12-29
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase.
Biochemistry, 37, 1998
1ARZ
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ESCHERICHIA COLI DIHYDRODIPICOLINATE REDUCTASE IN COMPLEX WITH NADH AND 2,6 PYRIDINE DICARBOXYLATE
Descriptor:DIHYDRODIPICOLINATE REDUCTASE, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Scapin, G., Reddy, S.G., Zheng, R., Blanchard, J.S.
Deposit date:1997-08-08
Release date:1998-10-14
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate.
Biochemistry, 36, 1997
1DAP
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C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH NADP+
Descriptor:DIAMINOPIMELIC ACID DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ACETATE ION
Authors:Scapin, G., Reddy, S.G., Blanchard, J.S.
Deposit date:1996-07-08
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum.
Biochemistry, 35, 1996
1OPR
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THE CRYSTAL STRUCTURE OF THE OROTATE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH OROTATE AND ALPHA-D-5-PHOSPHORIBOSYL-1-PYROPHOSPHATE
Descriptor:OROTATE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, OROTIC ACID, ...
Authors:Scapin, G., Sacchettini, J.C.
Deposit date:1995-01-06
Release date:1996-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate.
Biochemistry, 34, 1995
4Z9L
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THE STRUCTURE OF JNK3 IN COMPLEX WITH AN IMIDAZOLE-PYRIMIDINE INHIBITOR
Descriptor:Mitogen-activated protein kinase 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, CYCLOHEXYL-{4-[5-(3,4-DICHLOROPHENYL)-2-PIPERIDIN-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE, ...
Authors:Scapin, G., Patel, S.B., Lisnock, J., Becker, J.W., Lograsso, P.V., Smart, O.S., Bricogne, G.
Deposit date:2015-04-10
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.
Chem.Biol., 10, 2003
1DIH
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THREE-DIMENSIONAL STRUCTURE OF E. COLI DIHYDRODIPICOLINATE REDUCTASE
Descriptor:DIHYDRODIPICOLINATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Scapin, G., Blanchard, J.S., Sacchettini, J.C.
Deposit date:1994-09-14
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
Biochemistry, 34, 1995
1I57
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CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT
Descriptor:PHOSPHO-TYROSINE PHOSPHATASE 1B, MAGNESIUM ION, CHLORIDE ION
Authors:Scapin, G., Patel, S., Patel, V., Kennedy, B., Asante-Appiah, E.
Deposit date:2001-02-26
Release date:2001-08-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.
Protein Sci., 10, 2001
1IFC
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REFINEMENT OF THE STRUCTURE OF RECOMBINANT RAT INTESTINAL FATTY ACID-BINDING APOPROTEIN AT 1.2 ANGSTROMS RESOLUTION
Descriptor:INTESTINAL FATTY ACID BINDING PROTEIN
Authors:Scapin, G., Gordon, J.I., Sacchettini, J.C.
Deposit date:1991-12-19
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution.
J.Biol.Chem., 267, 1992
1PMN
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CRYSTAL STRUCTURE OF JNK3 IN COMPLEX WITH AN IMIDAZOLE-PYRIMIDINE INHIBITOR
Descriptor:Mitogen-activated protein kinase 10, CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE
Authors:Scapin, G., Patel, S.B., Lisnock, J., Becker, J.W., LoGrasso, P.V.
Deposit date:2003-06-11
Release date:2003-09-09
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity
Chem.Biol., 10, 2003
1PMU
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THE CRYSTAL STRUCTURE OF JNK3 IN COMPLEX WITH A PHENANTROLINE INHIBITOR
Descriptor:Mitogen-activated protein kinase 10, CHLORIDE ION, 9-(4-HYDROXYPHENYL)-2,7-PHENANTHROLINE
Authors:Scapin, G., Patel, S.B., Lisnock, J., Becker, J.W., LoGrasso, P.V.
Deposit date:2003-06-11
Release date:2003-09-09
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity
Chem.Biol., 10, 2003
1PMV
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THE STRUCTURE OF JNK3 IN COMPLEX WITH A DIHYDROANTHRAPYRAZOLE INHIBITOR
Descriptor:Mitogen-activated protein kinase 10, 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE
Authors:Scapin, G., Patel, S.B., Lisnock, J., Becker, J.W., LoGrasso, P.V.
Deposit date:2003-06-11
Release date:2003-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity
Chem.Biol., 10, 2003
1Q6J
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THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 2
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, [4-(2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)PHENYL](DIFLUORO)METHYLPHOSPHONIC ACID
Authors:Scapin, G., Patel, S.B., Becker, J.W., Wang, Q., Desponts, C., Waddleton, D., Skorey, K., Cromlish, W., Bayly, C., Therien, M., Gauthier, J.Y., Li, C.S., Lau, C.K., Ramachandran, C., Kennedy, B.P., Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6M
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THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 3
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, {[2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-(3,4-DIFLUOROPHENYL)PROPANE-1,3-DIYL]BIS[4,1-PHENYLENE(DIFLUOROMETHYLENE)]}BIS(PHOSPHONIC ACID)
Authors:Scapin, G., Patel, S.B., Becker, J.W., Wang, Q., Desponts, C., Waddleton, D., Skorey, K., Cromlish, W., Bayly, C., Therien, M., Gauthier, J.Y., Li, C.S., Lau, C.K., Ramachandran, C., Kennedy, B.P., Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6N
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THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 4
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, ...
Authors:Scapin, G., Patel, S.B., Becker, J.W., Wang, Q., Desponts, C., Waddleton, D., Skorey, K., Cromlish, W., Bayly, C., Therien, M., Gauthier, J.Y., Li, C.S., Lau, C.K., Ramachandran, C., Kennedy, B.P., Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6P
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THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 6
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, CHLORIDE ION, ...
Authors:Scapin, G., Patel, S.B., Becker, J.W., Wang, Q., Desponts, C., Waddleton, D., Skorey, K., Cromlish, W., Bayly, C., Therien, M., Gauthier, J.Y., Li, C.S., Lau, C.K., Ramachandran, C., Kennedy, B.P., Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6S
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THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 9
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, CHLORIDE ION, ...
Authors:Scapin, G., Patel, S.B., Becker, J.W., Wang, Q., Desponts, C., Waddleton, D., Skorey, K., Cromlish, W., Bayly, C., Therien, M., Gauthier, J.Y., Li, C.S., Lau, C.K., Ramachandran, C., Kennedy, B.P., Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6T
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THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 11
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, ...
Authors:Scapin, G., Patel, S.B., Becker, J.W., Wang, Q., Desponts, C., Waddleton, D., Skorey, K., Cromlish, W., Bayly, C., Therien, M., Gauthier, J.Y., Li, C.S., Lau, C.K., Ramachandran, C., Kennedy, B.P., Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1SO2
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR
Descriptor:cGMP-inhibited 3',5'-cyclic phosphodiesterase B, MAGNESIUM ION, 1-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL, ...
Authors:Scapin, G., Patel, S.B., Chung, C., Varnerin, J.P., Edmondson, S.D., Mastracchio, A., Parmee, E.R., Becker, J.W., Singh, S.B., Van Der Ploeg, L.H., Tota, M.R.
Deposit date:2004-03-12
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
Biochemistry, 43, 2004
1SOJ
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CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX
Descriptor:cGMP-inhibited 3',5'-cyclic phosphodiesterase B, MAGNESIUM ION, 3-ISOBUTYL-1-METHYLXANTHINE
Authors:Scapin, G., Patel, S.B., Chung, C., Varnerin, J.P., Edmondson, S.D., Mastracchio, A., Parmee, E.R., Becker, J.W., Singh, S.B., Van Der Ploeg, L.H., Tota, M.R.
Deposit date:2004-03-15
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
Biochemistry, 43, 2004
1STO
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CRYSTAL STRUCTURE OF OROTATE PHOSPHORIBOSYLTRANSFERASE
Descriptor:OROTATE PHOSPHORIBOSYLTRANSFERASE, HYDROXIDE ION, OROTIDINE-5'-MONOPHOSPHATE
Authors:Scapin, G., Grubmeyer, C., Sacchettini, J.C.
Deposit date:1993-12-20
Release date:1994-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of orotate phosphoribosyltransferase.
Biochemistry, 33, 1994
5DK3
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CRYSTAL STRUCTURE OF PEMBROLIZUMAB, A FULL LENGTH IGG4 ANTIBODY
Descriptor:Light Chain, Heavy Chain, SULFATE ION, ...
Authors:Scapin, G., Prosise, W., Reichert, P.
Deposit date:2015-09-02
Release date:2015-11-18
Last modified:2016-08-03
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab.
Nat.Struct.Mol.Biol., 22, 2015
6CE7
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INSULIN RECEPTOR ECTODOMAIN IN COMPLEX WITH ONE INSULIN MOLECULE
Descriptor:Insulin receptor, Insulin A chain, Insulin B chain, ...
Authors:Scapin, G., Dandey, V.P., Zhang, Z., Strickland, C., Potter, C.S., Carragher, B.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
6CE9
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INSULIN RECEPTOR ECTODOMAIN IN COMPLEX WITH TWO INSULIN MOLECULES
Descriptor:Insulin receptor, Insulin A chain, Insulin B chain, ...
Authors:Scapin, G., Dandey, V.P., Zhang, Z., Strickland, C., Potter, C.S., Carragher, B.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
6CEB
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INSULIN RECEPTOR ECTODOMAIN IN COMPLEX WITH TWO INSULIN MOLECULES - C1 SYMMETRY
Descriptor:Insulin receptor, Insulin A chain, Insulin B chain, ...
Authors:Scapin, G., Dandey, V.P., Zhang, Z., Strickland, C., Potter, C.S., Carragher, B.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018